iiinova — where your digital self keeps evolving

Reposted by Graille Lab

Carola Doerr @caroladoerr.bsky.social · 04/03/2025

Job alert: full-time researcher position for AI with CNRS here in France. Initial contract for 5 years (tenure track). Attractive starting package and better salary than regular positions. I have been w/ @cnrs.fr since 2013, it's great! Applications due 31/03 www.ins2i.cnrs.fr/en/cnrsinfo/...

ins2i.cnrs.fr

Choose France - CNRS AI Rising Talents

As part of the French Strategy in Artificial Intelligence (AI), the Choose France - CNRS AI Rising Talents program offers exceptionally tal

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Reposted by Graille Lab

Torben Heick Jensen @heick.bsky.social · 12/02/2025

Postdoc positions on nuclear RNA biology available in the Heick Jensen lab. Come join us in tiny Denmark. Interested? - then follow this link: mbg.au.dk/aktuelt/ledi...

mbg.au.dk

Postdoc positions in Nuclear RNA Biology - Ledig stilling på Aarhus Universitet

Ledig stilling ved Institut for Molekylærbiologi og Genetik - RNA-biologi og -innovation, Aarhus Universitet

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Reposted by Graille Lab

CBM CNRS UPR4301 @cbm-upr4301.bsky.social · 22/01/2025

2 positions open at @cbm-upr4301.bsky.social in #Orléans : - Engineer in cell biology : emploi.cnrs.fr/Offres/CDD/U... - Post-doc in conjugation and analytical chemistry : emploi.cnrs.fr/Offres/CDD/U...

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Graille Lab @graillelab.bsky.social · 21/01/2025

Pas sûr qu'ils atteignent 25% des labos avec ces critères. Ils pourront faire encore plus d'économies. C'est Bercy qui va être content de ces bons élèves...

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Reposted by Graille Lab

Schmitt-Mechulam Lab @tbioc.bsky.social · 16/01/2025

We are pleased to share our work on the evolution of translation initiation now published in Nature Communications. Take a look at leaderless mRNAs and eS26 in the small ribosomal subunit of Saccharolobus solfataricus. rdcu.be/d5pgg

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Reposted by Graille Lab

Marcin J. Suskiewicz @msuskiewicz.eurosky.social · 07/01/2025

Une ouverture pour un poste de professeur en biochimie au sein de notre équipe ! Consultez l'offre : www.univ-orleans.fr/upload/publi... Vous pouvez me/nous contacter pour toute question.

univ-orleans.fr

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Reposted by Graille Lab

TanentzapfLab @tanentzapflab.bsky.social · 13/12/2024

1. I feel like this is such obvious advice that it gets taken for granted & consequently no one says this to young scientists but READ PAPERS, read all the papers. As you move up in your career you will have less & less time to do this. Read everything that appeals to you not just in your field

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Reposted by Graille Lab

René Ketting @reneketting.bsky.social · 14/12/2024

We are looking for new group leaders. If RNA is your thing, and/or computational biology and you want to start your own group, check out these links. Feel free to contact me about these! And, please help me spread this. Thanks! www.imb.de/jobs/jobdeta... www.imb.de/jobs/jobdeta...

Reposted by Graille Lab

RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS @aribio.bsky.social · 06/12/2024

L´ingénieur viendra renforcer notre unité et en particulier mon équipe www.ferreiracercalab.com. Merci de partager cette information. Pour tous renseignements complémentaires, n´hésitez pas à nous solliciter.

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Reposted by Graille Lab

RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS @aribio.bsky.social · 06/12/2024

Bonjour, nous avons un poste d´IE en biochimie et biologie moléculaire ouvert en mobilité interne (FSEP) au laboratoire de biologie structurale de la cellule (BIOC) située au sein de l´École polytechnique (Palaiseau) . emploi.cnrs.fr/Offres/MOBIN...

emploi.cnrs.fr

Portail Emploi CNRS - Offre d'emploi - Ingénieur d'études en biochimie et en biologie moléculaire H/F

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Reposted by Graille Lab

Arne Elofsson @handle.invalid · 03/12/2024

AF3 BEST METHOD followed by cluspro but also some conversion errors

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Reposted by Graille Lab

Denis LJ Lafontaine @lafontainelab.bsky.social · 27/11/2024

Happy to share the website of RiboMod2025, the "Conference on Ribosomal RNA modifications and snoRNAs" in Bologna June 12-13, 2025 is up at events.unibo.it/ribomod2025 Stay tune for more infos! #RNA #Ribosome #snoRNA #Eiptranscriptomics

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Reposted by Graille Lab

Kasia Siudeja @ksiudeja.bsky.social · 25/11/2024

📣📣📣 Come join us and set up your team in the I2BC Cell Bio Dept! You will find great science, diverse topics and models, spacious labs, supportive environment, and fun colleagues. We are a short (train) ride south of Paris. Please DM me with any questions and help us spread the word 🙏

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Graille Lab @graillelab.bsky.social · 21/11/2024

Cool initiative. Could you please add my lab to this list? Thanks

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Graille Lab @graillelab.bsky.social · 21/11/2024

This project was done in collaboration with the groups of Hervé LE HIR (IBENS, Paris) and Cosmin Saveanu (Institut Pasteur) with the support from ANR (Agence nationale de la recherche), CNRS, École Polytechnique and Fondation ARC pour la recherche sur le cancer.

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Graille Lab @graillelab.bsky.social · 21/11/2024

Altogether, these results suggest that, during evolution, a general mechanism has been preserved to ensure the correct decay of aberrant mRNAs containing premature stop codons or transcripts with long 3’-UTRs.

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Graille Lab @graillelab.bsky.social · 21/11/2024

This UPF1-SMG6 interaction turns out to be important for the optimal degradation of NMD substrates in human cells. These data demonstrate that the Upf1-Nmd4 interaction is conserved in human, reinforcing the existence of a universal mechanism for the NMD pathway.

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Graille Lab @graillelab.bsky.social · 21/11/2024

We show that this region is important for the previously described phospho-independent interaction of the human SMG6 protein with the helicase domain of UPF1 and binds in a very similar way as yeast Nmd4 to UPF1 helicase domain.

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Graille Lab @graillelab.bsky.social · 21/11/2024

We also show that Nmd4 activates the ATPase activity of Upf1 and increases its affinity for RNA. Interestingly, we identify a region similar to yeast Nmd4 C-terminal arm in metazoan SMG6, the main enzyme that initiates RNA degradation in metazoan NMD.

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Graille Lab @graillelab.bsky.social · 21/11/2024

This article describes the crystal structure of the complex formed between the S. cerevisiae Nmd4 protein and the helicase domain of the Upf1 protein. This structure reveals that Nmd4 interacts with Upf1 helicase core through a conserved C-terminal arm.

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Graille Lab @graillelab.bsky.social · 21/11/2024

Very happy to share our new publication on the interaction between two nonsense mediated mRNA decay factors (Upf1 and yeast Nmd4 or human SMG6). 🍾 journals.plos.org/plosbiology/...

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