Ishiguro et al. identify stereoselective ribose-backbone methylations in the peptidyl-transferase center of E. coli ribosomes, installed by the cobalamin-dependent enzyme RlmX. These methylations, together with ho5C2501, are specifically induced under hypoxia. The hypoxia-induced modifications activate ribosomes, enhancing translational capacity and thereby promoting bacterial fitness in anaerobic conditions.

Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...

Distinguishing self from non-self is crucial to direct immune responses against pathogens. Unmodified RNAs stimulate human innate immunity, but RNA modifications suppress this response. mRNA m6A modif...

Explore the article collection: TRANSLACORE, a European network to coordinate research on translation regulation in cancer. Published in RNA Biology.

Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

An ancient tRNA modification is used by mammalian cells to coordinate protein translation and adaptive signaling.

Discover how unique ribosome fingerprints could revolutionize early cancer detection with non-invasive, portable scanners able to detect cancer with near-perfect accuracy.

This study identifies new Cajal body components and tests their roles in the formation of these nuclear membraneless organelles. Imbalances in the levels o

An RNA′s catalytic, regulatory, or coding potential depends on RNA structure formation. Because base pairing occurs during transcription, early structural states can govern RNA processing events and d...