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Reposted by Valentino Ribecco

EACR - European Association for Cancer Research @helloeacr.bsky.social · 17/11/2025

There's not long left for you to submit your abstract for Signalling Circuits in Cancer! If your research falls into any of these categories, don't miss your opportunity to be included in this new conference topic. eacr.org/conference/s...

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Valentino Ribecco @valentino-ribecco.bsky.social · 31/10/2025

Exciting day at BraYn Conference 2025 🇮🇹! I presented our work on how surgery impacts tumors and how its consequences can reduce the effectiveness of standard therapy in glioblastoma. Grateful for the inspiring discussions and amazing Neuro-Oncology session! 🧠💪 #Research #GBM #brayn2025

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Valentino Ribecco @valentino-ribecco.bsky.social · 29/10/2025

Excited to be in Turin for the 8th BraYn Conference – Brainstorming Research Assembly for Young Neuroscientists! 🧠✨ Looking forward to sharing ideas, learning from inspiring colleagues, and exploring new perspectives in neuroscience. #BraYn2025 #Neuroncology #Research #Torino #GBM #YoungScientists

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Valentino Ribecco @valentino-ribecco.bsky.social · 18/10/2025

A great day at EANO2025 where I had the opportunity to present our study: "Postsurgical ischemia fosters tumour cell plasticity in residual GBM" The need to study the impact of surgery on residual tumor cells is pivotal to understanding how residual tumor cells behave and how recurrence develops.

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Valentino Ribecco @valentino-ribecco.bsky.social · 16/10/2025

I’m truly honoured to has been selected for the EANO Young Investigator Scholarship by the EANO Scientific Committee for the 20th Meeting of the European Association of Neuro-Oncology in Prague. A heartfelt thank you to @eanoassociation.bsky.social, @giorgioseano.bsky.social , all my colleagues. 🙏

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Reposted by Valentino Ribecco

Giorgio Seano @giorgioseano.bsky.social · 16/10/2025

It is a true honor to have this opportunity to share our results at such a prestigious meeting again. If you are around, please come to my talk (OS05.7.A), see @valentino-ribecco.bsky.social presentation (OS03.6.A), and stop by Juliette Reveilles (P02.09.B) and Adrien Thomas' (P04.12.A) posters.

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Reposted by Valentino Ribecco

EACR - European Association for Cancer Research @helloeacr.bsky.social · 12/03/2025

Join us this November in Bergamo to help shape the future of early-onset cancer research! We're excited to bring you this brand new conference topic, exploring the biology, causes and detection of cancer in younger patients. In partnership with @themarkfdn.bsky.social 💙 eacr.org/conference/m...

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Reposted by Valentino Ribecco

EACR - European Association for Cancer Research @helloeacr.bsky.social · 30/07/2025

How can patients help shape the future of cancer research? Join us at our new virtual conference to explore how involving cancer patients in research leads to more meaningful, impactful outcomes. Learn more and register: eacr.org/conference/p...

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Reposted by Valentino Ribecco

Giorgio Seano @giorgioseano.bsky.social · 17/07/2025

🙏 This research wouldn’t have been possible w/o the work of Oceane Anezo, Jeremy Raymond, Alberto Ballestín, Cathy Pichol-Thievend, Juliette Reveilles, Adrien Thomas, @valentino-ribecco.bsky.social, and the collaboration with Celine Vallot, @ggargiul.bsky.social , Vidhya M. Ravi, Kevin Joseph (7/9)

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Reposted by Valentino Ribecco

Giorgio Seano @giorgioseano.bsky.social · 17/07/2025

🎉 Huge congrats to Guillaume Bourmeau, leading author and my brilliant PhD student, for spearheading this work on GBM hybrid cells at @institutcurie.bsky.social! Your dedication made this breakthrough possible. (6/9) #ProudPI,

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Reposted by Valentino Ribecco

Giorgio Seano @giorgioseano.bsky.social · 17/07/2025

🚀 Here's the exciting part: we can target this vulnerability. We hit them with importazole (import blocker) and selinexor (export inhibitor). 🔥 Targeting nuclear import decreases the hybrid cell pool and enhances chemoradiation sensitivity, opening a new therapeutic avenue against GBM. (5/9)

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Reposted by Valentino Ribecco

Giorgio Seano @giorgioseano.bsky.social · 17/07/2025

🛡️ Therefore, these cells are resistant to treatment and are linked to a poorer patient prognosis. Using RNA-seq, nuclear proteome and scChIP-Seq, we discovered their Achilles' heel: a hyperactive nuclear transport system they rely on to import oncogenes like MYC and maintain their state. (4/9)

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Reposted by Valentino Ribecco

Giorgio Seano @giorgioseano.bsky.social · 17/07/2025

🤯 These hybrid cells don’t just look different, they proliferate like they’re on Red Bull and shrug off DNA damage after irradiation. Have they got superhuman repair skills? 🙄 (3/9)

media.tenor.com

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Reposted by Valentino Ribecco

Giorgio Seano @giorgioseano.bsky.social · 17/07/2025

🔬 Using dual fluorescent reporters for proneural & mesenchymal states, we tracked live patient-derived glioblastoma lines and uncovered a hybrid population expressing both signatures... let's talk about an identity crisis! (2/9)

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Reposted by Valentino Ribecco

Giorgio Seano @giorgioseano.bsky.social · 17/07/2025

🧠 Why does glioblastoma always outsmart treatment? In our #Neuro-Oncology paper, we identified proneural-mesenchymal hybrid glioblastoma cells that are resistant to therapy and dependent on nuclear import. doi.org/10.1093/neuo... Short walkthrough below. Let’s dive in! 🧵 (1/9) #GBM, #BrainTumor

Background: Despite extensive research efforts, glioblastoma (GBM) remains a deadly disease with poor prognosis. Although previous studies have identified various cell states within GBM tumors, the molecular mechanism underlying adaptive GBM cell plasticity induced by conventional therapy remains unclear.
Methods: We used fluorescent reporters for proneural (PN) and mesenchymal (MES) subtypes to monitor GBM cell plasticity in real-time across multiple patient-derived cell lines. This approach revealed cells that concurrently expressed both proneural and mesenchymal markers. To investigate this unique hybrid population, we implemented a comprehensive methodological approach encompassing bulk and single-cell RNA sequencing, single-cell ChIP sequencing, nuclear proteomics, high-resolution imaging, orthotopic mouse models, clinical dataset analysis, and pharmacological and genetic techniques. This multifaceted strategy allowed us to gain functional and molecular insights into this distinct cellular population.
Results: We showed that these hybrid cells are increased by conventional therapies, and are resistant to these therapies. At the molecular level, hybrid cells display significant alterations in chromatin structure and nuclear protein composition, elevated transcriptional activity, Myc activation, and improved transport between the nucleus and cytoplasm. Genetic and pharmaceutical inhibition of the nuclear import/export shuttling machinery, increased in hybrid cells, effectively suppressed adaptive GBM cell plasticity and hybrid identity, thereby enhancing the sensitivity of GBM cells to therapies.
Conclusion: Our results indicate that GBM hybrid cells play a crucial role in chemoradiation resistance. The nuclear transport machinery presents a potential therapeutic target for hybrid cells, offering a way to counteract the typical resistance to treatment observed in GBM.

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Valentino Ribecco @valentino-ribecco.bsky.social · 02/04/2025

🚀 𝗕𝗿𝗲𝗮𝗸𝗶𝗻𝗴 𝗻𝗲𝘄 𝗴𝗿𝗼𝘂𝗻𝗱 𝗶𝗻 𝗴𝗹𝗶𝗼𝗯𝗹𝗮𝘀𝘁𝗼𝗺𝗮 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵! 🧠🔬 It’s a great pleasure to announce that my PhD work it’s finally out! After five years of dedicated effort, shared with two talented researchers Matteo Tamborini and Elisabetta Stanzani, this journey has been both challenging and rewarding. 1/5

academic.oup.com

Extracellular Vesicles Released by Glioblastoma Cancer Cells Drive Tumor Invasiveness via Connexin-43 Gap Junctions

AbstractBackground. Although invasiveness is one of the major determinants of the poor glioblastoma (GBM) outcome, the mechanisms of GBM invasion are only

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