iiinova — where your digital self keeps evolving

Reposted by Gabriele Corso

Tom Westgarth @tomwestgarth.bsky.social · 09/01/2026

Extremely exciting day for open science. Another reason to be bullish on UK AI. Boltz, a startup that emerged out of MIT to be at the frontier of small molecule and protein design, has moved to London. I hear cases like this from a few founders, often a mix of fundamentals (talent)+personal.

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Reposted by Gabriele Corso

Chaitanya K. Joshi @chaitjo.bsky.social · 08/01/2026

New blog 💙: I reflect on why I worked on what I worked on... I think a PhD is a very special time. You get to challenge yourself, push your boundaries, and grow. My thoughts go against the current AI/academia narrative online, so I hope you find it interesting. chaitjo.substack.com/p/phd-thesis...

chaitjo.substack.com

A Cambridge PhD thesis in three research questions

Geometric Deep Learning for Molecular Modelling and Design: A personal scientific journey

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Gabriele Corso @gcorso.bsky.social · 08/01/2026

All the credit goes to the entire Boltz team! Join us in this journey! jobs.gem.com/boltz

jobs.gem.com

Boltz Careers

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Gabriele Corso @gcorso.bsky.social · 08/01/2026

We will also be hosting Boltz launch parties that will include a demo, drinks, awesome discussions, and a giveaway of free credits. Sign up! San Francisco, Jan 15th: luma.com/yogmbte1 Boston, Jan 22nd: luma.com/6txhgndf London, Jan 29th: luma.com/8rar11y4 Virtual, Feb 2nd: luma.com/ttuhzb92

luma.com

Boltz Launch - San Francisco · Luma

Join us to celebrate the launch of Boltz Lab and Boltz PBC! 🎉🧬 We will give a short demo of Boltz Lab and its agents, followed by food, drinks and…

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Gabriele Corso @gcorso.bsky.social · 08/01/2026

Read more from the following longer-form blogs posts: - Our company manifesto: boltz.bio/manifesto - Our platform and agents announcement: boltz.bio/boltzlab - Our press release with Pfizer: boltz.bio/pfizer-partn... - Andrew Dunn article on Endpoints: endpoints.news/exclusive-bo...

boltz.bio

Boltz - Build Better Molecules with AI

Build better molecules with frontier AI models. With AI, we help every scientist reshape biology.

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Gabriele Corso @gcorso.bsky.social · 08/01/2026

Sign up to Boltz Lab today and you will also receive credits to start using the platform for free. We can’t wait to see what you build on Boltz Lab! lab.boltz.bio

lab.boltz.bio

Boltz

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Gabriele Corso @gcorso.bsky.social · 08/01/2026

All of this would not have been possible without first assembling an exceptional team. To support this team, we are honored to announce we’ve raised $28M seed round led by Zetta, Amplify, and a16z along with strategic angels including @clem.hf.co & @matthartman.bsky.social

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Gabriele Corso @gcorso.bsky.social · 08/01/2026

Over the past few months, we have already seen the success of the new agents and Boltz Lab in the hands of scientists across the field. Whether you are an individual researcher or a company the size of Pfizer, we can’t wait to see what you build with our tools in your hands.

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Gabriele Corso @gcorso.bsky.social · 08/01/2026

We are also excited to announce a multi-year collaboration with Pfizer, to put Boltz Lab and its agents in the hands of Pfizer scientists, and to work together on new foundation models leveraging Pfizer data.

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Gabriele Corso @gcorso.bsky.social · 08/01/2026

We’ve focused on optimization + infrastructure so results arrive quickly, we have generous free tiers, and costs are lower than open-source, without users taking on the engineering. We have clear terms: you own your outputs, your data stays secure, and we don’t train on your data

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Gabriele Corso @gcorso.bsky.social · 08/01/2026

We’ve made these agents the core of Boltz Lab, a new platform designed around real bio/chem workflows, removing adoption bottlenecks like compute cost, scalable infrastructure, and collaborative interfaces.

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Gabriele Corso @gcorso.bsky.social · 08/01/2026

We have been hard at work building and validating the next generation of small-molecule and protein design agents that more deeply leverage our models driving significant improvements. We’re releasing the first versions of these agents and sharing some great initial results!

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Gabriele Corso @gcorso.bsky.social · 08/01/2026

We are not a therapeutics company. Our goal is to build a product that allows every scientist to go from a therapeutic hypothesis to a human-ready molecule without leaving their computer. As a first step, we are releasing a preview of Boltz Lab, our platform alongside new AI agents.

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Gabriele Corso @gcorso.bsky.social · 08/01/2026

We believe the frontier should stay open enough to maximize scientific and patient impact. That’s why we founded Boltz PBC, a Public Benefit Corporation: advance AI for biology through open science, and make it accessible to every scientist building a healthier future.

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Gabriele Corso @gcorso.bsky.social · 08/01/2026

As researchers, we have seen firsthand the power of open science. Our models, Boltz-1, Boltz-2 and BoltzGen, have already been used by over a hundred thousand scientists in both academia and industry and form the foundation for countless pipelines, agents, and platforms.

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Gabriele Corso @gcorso.bsky.social · 08/01/2026

AI-powered molecular modeling is advancing fast with the promise of making biology programmable, digitizing experiments, and dramatically speeding up drug discovery. But the field is trending more closed, severely limiting the impact on science and, most importantly, on patients.

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Gabriele Corso @gcorso.bsky.social · 08/01/2026

Big news from Boltz today: we’re launching Boltz Lab, a new platform with new small-molecule + protein design agents, announcing Boltz PBC and a $28M seed round, and sharing a multi-year partnership with Pfizer. More below!

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Reposted by Gabriele Corso

Chaitanya K. Joshi @chaitjo.bsky.social · 03/12/2025

Introducing gRNAde: our own little "AlphaGo Moment" for RNA design! 🧬🚀 📝: tinyurl.com/gRNAde-paper Unlike proteins, RNA design has long relied on "wisdom of the crowd" (human experts) or the slow crawl of directed evolution — gRNAde changes that! 🧵👇

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Reposted by Gabriele Corso

MIT Jameel Clinic @mitjameelclinic.bsky.social · 30/10/2025

Join us today at MIT from 5pm-6pm for a seminar for BoltzGen, which is free and open to the public! Looking forward to seeing you all later today! 🤩 If you plan to attend, don't forget to RSVP so we can plan accordingly: luma.com/7474iho2 #AISky #AcademicSky

Blue and white graphic overlaid with text that reads "Introducing BoltzGen: Toward Universal Binder Design" followed by headshots and names of the speakers starting from the top "Hannes Stark, PhD student, MIT; Regina Barzilay, AI Faculty Lead, MIT Jameel Clinic; Tommi Jaakkola, Principal Investigator, MIT Jameel Clinic" Followed by event details: "When: Thursday, Oct. 30, 5pm-6pm; Where: 32-123, Stata Center; RSVP jclinic.mit.edu/events/boltzgen/"

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Reposted by Gabriele Corso

Tim O'Donnell @timodonnell.bsky.social · 27/10/2025

One cool thing about BoltzGen is the flexibility of the conditioning information you can provide (e.g. "constrain the structure of these residues and also these but let their relative placement vary"). I'm really curious to see what the community does with it! github.com/HannesStark/...

github.com

GitHub - HannesStark/boltzgen

Contribute to HannesStark/boltzgen development by creating an account on GitHub.

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Anton Bushuiev @anton-bushuiev.bsky.social · 27/10/2025

Very happy @roman-bushuiev.bsky.social and I joined the amazing team led by @hannes-stark.bsky.social to work on BoltzGen, a generative model for binder design based on Boltz-2. Excited what it will enable!

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Reposted by Gabriele Corso

Andrew Savinov @biosavinov.bsky.social · 27/10/2025

Thrilled to contribute to this exciting work on protein binder design together w/ @hannes-stark.bsky.social , Felix Faltings, Regina Barzilay, Tommi Jaakkola, and co. We applied BoltzGen to design novel antimicrobial peptides targeting DNA gyrase based on inhibitory protein fragments. (1/n)

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Albert Vilella, PhD. @albertvilella.bsky.social · 27/10/2025

BoltzGen now published and available as MIT licensed software

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Reposted by Gabriele Corso

Brian Naughton @btnaughton.bsky.social · 27/10/2025

I’ve been testing BoltzGen a bit recently and while I haven’t done any experimental testing yet, the quality of the software is very clear. It installs, runs, logs everything, has tons of options. Very excited to test out the designs irl!

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Reposted by Gabriele Corso

Hannes Stark @hannes-stark.bsky.social · 26/10/2025

Excited to release BoltzGen which brings SOTA folding performance to binder design! The best part of this project is collaborating with a broad network of leading wetlabs that test BoltzGen at an unprecedented scale, showing success on many novel targets and pushing the model to its limits!

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Gabriele Corso @gcorso.bsky.social · 17/09/2025

Pretty surreal when out of the blue you see your model up on an ad on highway billboards and airport screens 🤯 (pictures from San Diego Airport and a highway in SF)

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Gabriele Corso @gcorso.bsky.social · 09/09/2025

Boltz v2.2.1 out. A few improvements including support for .pdb templates, better treatment of stereochemistry in guidance potentials, and improved documentation. As always a great thank you to all those in the community who contributed via PR, raising issues or directly reporting issues to us.

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Gabriele Corso @gcorso.bsky.social · 09/09/2025

Sitting at the #AITHYRA symposium hearing about incredible new high-throughput datasets 🤯! If you have developed new data that you think could improve Boltz, e.g. protein small-molecule affinity, protein protein affinity, binding site (eg via proteomics), let's work together! 🤗

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Gabriele Corso @gcorso.bsky.social · 09/09/2025

Have you tried using the --use_potentials flag?

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Reposted by Gabriele Corso

ChimeraX @chimerax.ucsf.edu · 20/08/2025

Here's how to predict binding of tens or hundreds of small molecules to protein assemblies using Boltz 2 in ChimeraX. Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures. www.rbvi.ucsf.edu/chimerax/dat...

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Reposted by Gabriele Corso

Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 15/08/2025

If you use Boltz1/2, BioEmu, Chai1, or other MSA-dependent models, you’re likely using our ColabFold server. Please be considerate! Avoid large submissions across many IPs instead generate the MSA locally. Our server is an old-timer from 2014 and can’t handle that load.

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ChimeraX @chimerax.ucsf.edu · 24/07/2025

ChimeraX daily builds can predict binding affinity of small molecules using Boltz 2 on your Mac, Windows or Linux computer. www.rbvi.ucsf.edu/chimerax/dat...

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Reposted by Gabriele Corso

Alexander Ille @alexander-ille.bsky.social · 04/07/2025

Excited to share our work on modeling the human protein interactome in 3D. This currently includes 1,394 interaction structures predicted with Boltz-2. Grateful for the open-access resources making this possible! Preprint: doi.org/10.1101/2025...

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 19/06/2025

Boltz-2 : Towards accurate and efficient binding affinity prediction by @gcorso.bsky.social Saro Passaro and Jeremy Wohlwend youtu.be/iHDauMATkr0?...

youtu.be

Boltz-2: Towards Accurate and Efficient Binding Affinity Prediction

YouTube video by Valence Labs

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Gabriele Corso @gcorso.bsky.social · 17/06/2025

Nice interview of Phil Sharp on the controversial birth of biotech and recombinant DNA with some great analogies to the current discourse on AI and gene editing! - YouTube www.youtube.com/watch?v=LLij... - Spotify spotifycreators-web.app.link/e/NNmzqnTjgUb - Apple podcasts.apple.com/us/podcast/h...

youtube.com

The Nobel that Sparked Biotech - Prof Phil Sharp

YouTube video by Health Horizons

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Gabriele Corso @gcorso.bsky.social · 14/06/2025

We will be hosted by @hannes-stark.bsky.social in his renowned reading group!

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Gabriele Corso @gcorso.bsky.social · 14/06/2025

Thank you everyone for attending the Boltz-2 Boston, San Francisco and Paris events this week! Given the success of the in-person seminars and the many requests, we are organizing a virtual seminar on Tuesday at 12pm ET / 6pm CET! Sign up here: lu.ma/4bpuwbsr

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Science X / Phys.org @sciencex.bsky.social · 10/06/2025

A new AI model jointly predicts protein structure and binding affinity, enabling rapid, accurate screening of small molecules and accelerating early-stage drug discovery. Boltz-2 is now open source.

phys.org

Protein-binding affinity model expands role of AI in drug discovery

Understanding how molecules interact is central to biology: from decoding how living organisms function to uncovering disease mechanisms and developing life-saving drugs.

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Reposted by Gabriele Corso

Recursion @recursionpharma.bsky.social · 13/06/2025

Open science, activated. Since the release of Boltz-2 last Friday – the new open-source protein structure and protein binding affinity model from MIT & Recursion – we’ve been introducing the model to the broader community and the reception has been terrific. 🧵

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Recursion @recursionpharma.bsky.social · 13/06/2025

On June 18 at the Molecular Machine Learning Conference (MoML) at MILA, Gabriele Corso, one of the lead researchers behind Boltz-2, will present more on this latest breakthrough in AI drug discovery alongside researchers from Valence. 👉 Learn more: portal.ml4dd.com #MOML2025

portal.ml4dd.com

Home | MoML 2025

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Kyle Tretina @allthingsapx.bsky.social · 13/06/2025

Boltz-2 just dropped: open-source AI that predicts both protein complex folds ✚ binding affinities in one shot 🚀 This is a win for protein AI, but let's not forget MSAs, the bioinformatics backbone many structure models lean on.

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Open Free Energy @openfree.energy · 13/06/2025

It's exciting to see our software used as a benchmark for cutting-edge AI methods!

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C&EN (Chemical & Engineering News) @cenmag.bsky.social · 10/06/2025

A team led by Regina Barzilay, a computer science professor at MIT, has launched Boltz-2, an algorithm that unites protein folding and prediction of small-molecule binding affinity in one package. cen.acs.org/pharmaceutic... #chemsky 🧪

cen.acs.org

MIT and Recursion partner for AI drug discovery tool

Freely available Boltz-2 algorithm can predict small-molecule binding affinities

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MIT Jameel Clinic @mitjameelclinic.bsky.social · 10/06/2025

What a turnout! 🤯 Thank you to the 400+ attendees who came to listen to the first-ever Boltz-2 presentation in-person and for asking great questions! We look forward to seeing how Boltz-2 will empower future research in biomolecular structure prediction! 🧬🔥 #AIsky

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The Mark Foundation for Cancer Research @themarkfdn.bsky.social · 09/06/2025

Boltz-2 is here—and it’s poised to transform preclinical drug development. We were lucky to get a preview from Regina Barzilay at our 2025 Scientific Symposium, and we’re proud to support her work on the @cancergrand.bsky.social Matchmakers team. www.cancergrandchallenges.org/news/boltz-2...

cancergrandchallenges.org

Boltz-2: democratising the future of drug design

Open source structure prediction with binding affinity

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MIT Jameel Clinic @mitjameelclinic.bsky.social · 09/06/2025

'93 Nobel Prize laureate and Jameel Clinic Advisory Board Chair Phil Sharp breaks down why Boltz-2 is so groundbreaking. Join @gcorso.bsky.social + @jeremywohlwend.bsky.social today @ 4pm in Stata Center for their talk on Boltz-2! 🗓️RSVP: jclinic.mit.edu/events/unvei... 🎬: youtu.be/YDrFggLBEQw?...

youtu.be

'93 Nobel Laureate Phillip Sharp on significance of Boltz-2 and affinity binding

YouTube video by MIT Jameel Clinic - AI & Health

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