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Alexander Ille

@alexander-ille.bsky.social

13 followers 13 following 17 posts

Postdoctoral Researcher @ Rutgers University Passionate about molecular biology and AI/ML

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Alexander Ille @alexander-ille.bsky.social · 27/08/2025

State of the art!

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Alexander Ille @alexander-ille.bsky.social · 21/08/2025

Excited to share an update of our work on modeling the human protein interactome in 3D using Boltz-2. Large-scale protein complex prediction allows for exploring structurally-informed biological networks. Preprint on bioRxiv: doi.org/10.1101/2025...

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Reposted by Alexander Ille

RCSB Protein Data Bank @rcsbpdb.bsky.social · 20/08/2025

Eat your carrots or you'll go blind! The biochemical reason for this warning is that we need retinal, vitamin A, to form the pigment that absorbs light in our eyes. More at Molecule of the Month: pdb101.rcsb.org/motm/66 #PeakPerformance

Vitamin A plays a crucial role in vision by converting light into electrical signals. At the heart of this process are rhodopsin proteins (purple) found in the retina, a light-sensing tissue at the back of the eye. Vitamin A is the precursor to retinal (yellow), which is nestled within the active site of rhodopsin. When light strikes retinal, it transforms from its cis form to its trans form (see inset), allowing rhodopsin to bind and activate its associated G-protein complex (green). This process sets off a cascade of events that ultimately leads to the perception of light.
Visit the 2025 Calendar: The Structural Biology of Nutrition to learn more.
Illustration by RCSB PDB intern Xinyi Christine Zhang.

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Alexander Ille @alexander-ille.bsky.social · 04/07/2025

Excited to share our work on modeling the human protein interactome in 3D. This currently includes 1,394 interaction structures predicted with Boltz-2. Grateful for the open-access resources making this possible! Preprint: doi.org/10.1101/2025...

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Alexander Ille @alexander-ille.bsky.social · 24/06/2025

Excited to share a new article I co-authored on the relationship between biological sequence and structure! We look back to historic hypotheses, and look forward to how AI/ML models may be developed to predict protein conformational dynamics. Paper: doi.org/10.1063/4.00...

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Alexander Ille @alexander-ille.bsky.social · 18/06/2025

Hemoglobin, the biomolecule that breathes, modeled with Boltz-2. With the recent release of #Boltz2, I gave it a try for modeling hemoglobin. Hemoglobin structures were likely included for training, and this was just a fun test, but it’s awesome to see this modeling in action!