iiinova — where your digital self keeps evolving

Reposted by Florent Waltz

Jonas Wietek @jwietek.bsky.social · 07/10/2026

🧠⚡️🌈🧫🦠💡🔬

Florent Waltz @florentwaltz.bsky.social · 07/10/2026

Curious use of "atomic resolution" here, while none of the maps are at 1.2 angstrom? 🔬🫣 @eLife.bsky.social: On the Polymorph-Selection Determinants of α-Synuclein Amyloid Fibrils Studied at Atomic Resolution doi.org/10.7554/eLif...

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Florent Waltz @florentwaltz.bsky.social · 06/10/2026

That's great ! Such an important resource for the community

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Florent Waltz @florentwaltz.bsky.social · 06/10/2026

Chlamy can probably do that also ???

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Florent Waltz @florentwaltz.bsky.social · 06/10/2026

Hoping for Chlamydomonas derived physics

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Florent Waltz @florentwaltz.bsky.social · 06/10/2026

Evolution and natural selection are Nature's algorithms. After running for 3 billion years they surely produced some interesting results, we just have to take a look :}

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Florent Waltz @florentwaltz.bsky.social · 05/10/2026

Huge congratulations to all three Nobel Laureates, and especially Peter Hegemann! 👏 His seminal work on the green alga Chlamydomonas 🦠 laid the foundation for optogenetics. Thank you for putting Chlamy in the spotlight! ✨ Proof that groundbreaking discoveries don't always come from animal models! 🔬

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Florent Waltz @florentwaltz.bsky.social · 02/10/2026

Apparently more than just rubisco! Who knew?!

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Reposted by Florent Waltz

Manon Demulder @manondemulder.bsky.social · 02/10/2026

If you’ve always been curious about how algae fix carbon, @phaips.vd.st, @cellarchlab.com and I have put together the quickest route into pyrenoids. And if you don’t feel like reading at all, we have an accompanying poster doi.org/10.1242/jcs....

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Florent Waltz @florentwaltz.bsky.social · 01/10/2026

C'est surtout: "Les futures guerres des États-Unis" On prévoit des choses joyeuses.

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Florent Waltz @florentwaltz.bsky.social · 30/09/2026

Maybe time to switch to coot1 ...

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Florent Waltz @florentwaltz.bsky.social · 29/09/2026

Comment est-ce possible d'avoir 66 000 candidats de plus d'une année sur l'autre? Et surtout, comment c'est possible de ne pas prévoir ça ....

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Florent Waltz @florentwaltz.bsky.social · 24/09/2026

C'est déjà le cas pour une grande partie des jeux mobiles.... Je suis surpris qu'il y ait même besoin d'un dépôt de brevet 👀

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Florent Waltz @florentwaltz.bsky.social · 24/09/2026

Congrats! Funny shape, I thought I was looking at a 48S translation pre-initiation complex at first!

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Florent Waltz @florentwaltz.bsky.social · 23/09/2026

Loterie Romande giving away random Swiss lakes protists?

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Florent Waltz @florentwaltz.bsky.social · 22/09/2026

... For the sponsoring the talk and poster prizes, that went to @fannyleblanc.bsky.social and Aurélien Gregor 🎊. And huge thanks to @sofie-dot-rec.bsky.social, @phaips.vd.st and Imre Gonda for teaching the workshop on sample prep, data collection and processing on the 2nd day. #cryoET #TeamTOMO

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Florent Waltz @florentwaltz.bsky.social · 22/09/2026

Great success for the 2nd edition of the Young Swiss Tomo Meeting in Bern 🔬, co-organized with the DCI, and @leonieanton.bsky.social, Elsa Bauda, @zanettakechagia.bsky.social and Agnes Moe who's joining the team for the next edition. Thanks to @dectris.bsky.social and @thermofishersci.bsky.social ..

Kuppelraum at Bern university. 70 people attending the conference

The organizers
Florent Waltz, Leonie Anton, Elda Bauda, Zanetta Kechagia and Agnes Moe

The organizers plus the workshop teachers, Philippe van der Stappen, Sofie van Dorst and Imre Gonda

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Florent Waltz @florentwaltz.bsky.social · 19/09/2026

AI polemic aside, beautiful pictures there 😍! N°5 - Mitochondria trafficking in plant cells 🌿 www.nikonsmallworld.com/galleries/20... N°15 - Beautiful Volvox swimming around 🦠 www.nikonsmallworld.com/galleries/20... N°26 - Dinoflagellate bioluminescence 🩵 www.nikonsmallworld.com/galleries/20...

nikonsmallworld.com

Dynamics of mitochondria and chloroplasts in Turtle Vine leaf cells | 2026 Small World in Motion Competition

Patrick Hickey - Dynamics of mitochondria (green) and chloroplasts (red) in Turtle Vine leaf cells (Callisia repens)

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Florent Waltz @florentwaltz.bsky.social · 18/09/2026

For sure Migros! But it might also come from EDEKA, I don't quite remember if this was purified in Switzerland or Germany 🤣

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Florent Waltz @florentwaltz.bsky.social · 13/09/2026

J'ai posté en commentaire le lien vers de l'article en question (www.nature.com/articles/s41... ) et répondus aux personnes qui demandaient le lien. Mes commentaires ont été supprimés ! WTF ?! Une explication? Pourquoi ne pas partager les études qui inspirent les vidéos ?

nature.com

Structural basis of transcription of the hachimoji eight-letter alphabet by E. coli RNA polymerase - Nature Communications

Expanded genetic alphabets can increase the functional diversity of nucleic acids, but their compatibility with cellular transcription is uncertain. Here, the authors show that bacterial RNA polymeras...

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Florent Waltz @florentwaltz.bsky.social · 13/09/2026

Que ce soit dans les vidéos ou dans leurs descriptions, on a juste droit a "une équipe américaine" ou équivalent. Les news sont aussi reprises sur les sites internets du service publique, notamment @radiofrance.fr mais la encore aucune source ou citation.

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Florent Waltz @florentwaltz.bsky.social · 13/09/2026

Pour mes collègues francophone. Je scrollais Instagram, et je tombe sur la page "le billet science" tenue apparemment par @franceinfo.fr et @billfrancois.bsky.social. La page vulgarise des news scientifiques, bcp de vues et de followers. Par contre, AUCUNE source, DOI, ou citations.

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Reposted by Florent Waltz

Leonie Anton @leonieanton.bsky.social · 03/09/2026

I am excited to share that I will start my group @embl.org in Grenoble in February 2027, where we will investigate host-pathogen interactions using in situ cryo electron microscopy🦠❄️🔬! I am recruiting PhD students through the current open call of the EMBL PhD Program: www.embl.org/about/info/e...

embl.org

Anton Group – Cellular structural biology of host-pathogen interactions

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Reposted by Florent Waltz

Caitie McCafferty @computingcaitie.bsky.social · 09/09/2026

I am looking for a lab manager for my group that I will be starting at the @fmiscience.bsky.social in February! We will use in situ structural biology to investigate dynamic ciliary processes. More info here —> bsky.app/profile/comp... #cilia #teamtomo #proteomics #protistsky

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Reposted by Florent Waltz

FMI science @fmiscience.bsky.social · 09/09/2026

📢 We’re hiring! Join Caitlyn McCafferty’s (@computingcaitie.bsky.social) new group as Lab Manager and help shape lab operations, develop protocols and support research on the structure and dynamics of motile cilia. Apply by October 9: www.fmi.ch/education-ca...

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Florent Waltz @florentwaltz.bsky.social · 08/09/2026

Yoooo it's out 🥳 MemBrain v3 when ?

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Reposted by Florent Waltz

Florian Wollweber @florianwollweber.bsky.social · 05/09/2026

Exciting news! Our @erc.europa.eu StG project ARCHAEAOLOGY got funded 🎉 We’ll combine cryoET/EM, ExM & spatial omics to explore the subcellular organization of Asgard archaea. Job ads coming soon! 🦠 ❄️ 🔬 #TeamTomo #ArchaeaSky #MicroSky

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Reposted by Florent Waltz

Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 30/08/2026

Run AlphaFold2 locally in your browser via WebGPU, no installation needed, it's just a static webpage using your own GPU or CPU. Short proteins run in seconds. Larger ones are still slow: a 291-aa protein takes ~7 minutes on my M4 Pro. ❗It's just a PoC. 🌐 martin-steinegger.github.io/alphafold2-w...

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Reposted by Florent Waltz

Janani Durairaj (Jay) @ninjani.bsky.social · 28/08/2026

Some exciting news: I'm joining the University of Lausanne @unil.bsky.social @dbc-unil.bsky.social as an Assistant Professor next month 🎉 My group will work on context-aware deep learning for protein structure, interaction & design. Postdoc and PhD openings coming soon - keep an eye out!

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Florent Waltz @florentwaltz.bsky.social · 26/08/2026

Do you even still want to run a western at this point?

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Florent Waltz @florentwaltz.bsky.social · 26/08/2026

The best term is probably "cellular cryo-EM." "In cellulo" is complete pseudo-Latin. "In situ" is just too ambiguous unless you explicitly specify what kind of in situ environment you mean. Just drop the latin all together 😅

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Reposted by Florent Waltz

Reese Richardson @reeserichardson.bsky.social · 25/08/2026

A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵

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Florent Waltz @florentwaltz.bsky.social · 07/08/2026

I had to read this one outloud to get it ...🤣 Indeed! If you can get away without tilting or FIBing you totally should! I'm talking about concluding things on general organisation when the native context is clearly disturbed.

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Florent Waltz @florentwaltz.bsky.social · 07/08/2026

Exactly! Though it seems like everything after "in situ" got dropped 🙃 Probably didn't fit the title length limit 🤓

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Florent Waltz @florentwaltz.bsky.social · 07/08/2026

Yeah, it gets even trickier when cell biologists remind you that working with cell lines is actually in vitro.

static.klipy.com

Elmo Surrounded by Intense Fire

ALT: Elmo Surrounded by Intense Fire

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Florent Waltz @florentwaltz.bsky.social · 07/08/2026

Just trying to raise awareness on that, which is become more and more a subject of concern in the @cellarchlab.com and happy to hear the opinion of everyone. #cryo-ET #cryo-EM #cryoET #cryoEM #TeamTomo

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Florent Waltz @florentwaltz.bsky.social · 07/08/2026

Sure, we can't do FIB-milling + cryo-ET on every single system yet due to technical limits. I've also worked with purified mitochondria. But we need to be precise in our terminology. Working with purified membranes or broken organelles? Just say so. Don't try to hide behind a general term 8/n

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Florent Waltz @florentwaltz.bsky.social · 07/08/2026

Then, i would be careful for anything that sits in a membrane. So the same goes for mitochondria, my favorite cellular organelle 😍, and for anything sensitive to concentration, osmolarity, or mechanical stress (e.g phase separation). 7/n

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Florent Waltz @florentwaltz.bsky.social · 07/08/2026

This work clearly shows that even within native membranes of purified chloroplast 🌿, the integrity of the organelle impacts photosystem organization, you can see a complete reorganisation. It gets tricky to draw solid biological conclusions if the starting preparation changes the architecture. 6/n

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Florent Waltz @florentwaltz.bsky.social · 07/08/2026

However, if you want to study higher-order organization, supercomplexes, or spatial distribution... then you really don’t want to work with anything purified. A great recent example from the @cellarchlab.com lab by @wojwie.bsky.social nicely shown here: bsky.app/profile/cell... 5/n

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Florent Waltz @florentwaltz.bsky.social · 07/08/2026

I would argue that "true native" is always better (of course the #TeamTomo guy says that), though not always necessary depending on the question. You just want to solve the structure of a soluble complex or membrane protein? Then purified or semi-purified is probably fine. 4/n

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Florent Waltz @florentwaltz.bsky.social · 07/08/2026

The trouble starts when in situ is used synonymously for all these different conditions. It creates confusion and risks leading the field to assume in situ automatically means "native". But are purified organelles really as native as looking inside a whole cell via FIB-milling? 3/n

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Florent Waltz @florentwaltz.bsky.social · 07/08/2026

"In situ" means "in position" or "in the original place." But that could be interpreted in many ways. Is a complex purified from native membranes considered in situ? What about imaging them in purified organelles? Maybe... but at that point, it’s also very much ex vivo 😅. 2/n

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