iiinova — where your digital self keeps evolving

FaceBase @facebase.bsky.social · 04/08/2026

Why do some cranial sutures fuse too early? New FaceBase data point to timing: FGFR2 signaling normally declines after birth, dialing down retinoic acid to keep the coronal suture open. Overactivate it and the suture closes. RNA-Seq, Chai lab, USC. @ccmb.usc.edu www.facebase.org/2026/08/04/r...

FGFR2-RA signaling governs dura mater-suture mesenchyme interaction during early postnatal development to control coronal suture development and craniosynostosis. Illustration created with BioRender.com.

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FaceBase @facebase.bsky.social · 31/07/2026

How do continuously growing teeth withstand constant mechanical load? New FaceBase data identify a KDM6B–BMI1–PIEZO1 "mechanostat" that shields incisor progenitors from stress-induced apoptosis. Bulk RNA-seq + Cut&Run-seq, Chai lab, USC. www.facebase.org/2026/07/30/r...

Schematic representation of KDM6B safeguarding tissue homeostasis to mechanical stress through epigenetic control of PIEZO1- mediated mechanotransduction. Using the mouse incisor as a model of mechanical loading, we reveal that within TACs, Kdm6b demethylates H3K27me3, thereby relieving the repression of the Bmi1 gene. Normal BMI1 inhibits Piezo1 expression. This maintains physiological PIEZO1 levels, ensuring calibrated Ca2+ influx for proliferation and differentiation. In contrast, loss of Kdm6b leads to an accumulation of H3K27me3 at the Bmi1 promoter region, which silences Bmi1 expression and diminishes BMI1 formation. This reduction results in pathologically increased PIEZO1 ion channels in the membrane. The subsequent Ca2+ overload triggers TAC apoptosis while reducing proliferation and differentiation. Ultimately, these molecular events compromise tissue homeostasis. Schematic created with BioRender.com. Ho, T. (2026) https://BioRender.com/8mzv4a

FaceBase @facebase.bsky.social · 28/07/2026

It's that time again! Join us for our Office Hours tomorrow: 📅 Wednesday, July 29, 1 pm ET / 10 am PT Zoom with FaceBase team members and ask questions about finding data, submitting data, citing data, and more things data! Click here to register: usc.zoom.us/meeting/regi...

FaceBase @facebase.bsky.social · 15/07/2026

Save the date! The 2027 FaceBase Community Forum heads to Los Angeles — April 27–28, 2027, at USC/ISI in Marina del Rey. Details soon: bit.ly/FBForum2027

Save the Date Flyer with navy and gold highlights displaying initial details for the 2027 FaceBase Community Forum: April 27 & 28, 2027 at USC Information Sciences Institute, 4676 Admiralty Way, Marina del Rey, CA. Inviting: researchers, clinicians, data scientists trainees. Focused on: dental, oral, craniofacial, inner ear and related health domains. More details coming soon. Check for updates at: https://bit.ly/FBForum2027

FaceBase @facebase.bsky.social · 30/04/2026

New on FaceBase: single-cell RNA-seq data from a knock-in mouse model reveals how amelogenin phosphorylation shapes enamel organ biology — including 5.1-fold downregulation of Shh in secretory ameloblasts. Explore the dataset from Beniash/Margolis, Univ of Pittsburgh: doi.org/10.25550/AF-...

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FaceBase @facebase.bsky.social · 20/04/2026

We've extended the poster abstract deadline for the 2026 FaceBase Annual Meeting! Share your work and connect with the craniofacial research community. Deadline is now: Friday, April 24. Submit here → facebase.org/community/annual-meeting/2026-facebase-annual/abstracts/

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FaceBase @facebase.bsky.social · 17/04/2026

New on FaceBase 🧬 Xu, Liu & Jiang (Cincinnati Children's) contribute Six2 and CTCF ChIP-seq datasets from wildtype mouse embryonic facial tissues (E10.5–E13.5), shedding light on the regulatory landscape of craniofacial morphogenesis. doi.org/10.25550/7Z-...

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FaceBase @facebase.bsky.social · 14/04/2026

📋 A few days left to submit a poster abstract for the 2026 FaceBase Annual Meeting! Share your work and connect with the craniofacial research community. Deadline: Friday, April 17. Submit here → facebase.org/community/annual-meeting/2026-facebase-annual/abstracts/

FaceBase @facebase.bsky.social · 10/04/2026

New on FaceBase 🧬 A new dataset from Ma & Rosin examines how prenatal depletion of CSF1R+ macrophages and osteoclasts disrupts craniofacial development — with effects on the skull, mandible, palate, ear ossicles, and more. Dataset + publication now available. www.facebase.org/2026/04/09/r...

An example one of the PLX5622 treated P1 skulls. Image by Felix Ma and Jessica M. Rosin.

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FaceBase @facebase.bsky.social · 20/03/2026

Will you be at AADOCR/IADR or GRC next week? FaceBase will be in Ventura and San Diego with demos, presentations, and opportunities to connect with our team. See where to find us! www.facebase.org/2026/03/19/f...

A view of the San Diego Convention Center, where the AADOCR/IADR will be held next week. See FaceBase in Booth 402!

FaceBase @facebase.bsky.social · 18/03/2026

FACEBASE COMMUNITY FORUM 🗓 Abstract Deadline for Talk Consideration - This Friday, March 20! Submissions will remain open after this first deadline. This deadline only applies to abstracts that would like to be considered for a talk. Submit abstract ➡️ www.facebase.org/community/an...

facebase.org

Call for Abstracts for the 2026 FaceBase Community Forum

FaceBase is the primary data resource for craniofacial researchers worldwide.

FaceBase @facebase.bsky.social · 05/03/2026

New data: Spatial transcriptomics (using seqFISH) reveals a fibroblast-immune microenvironment remodeling pathway in CFA-induced TMJ arthritis in mice. PI: Jian-Fu Chen (University of Southern California) doi.org/10.25550/8Q-...

Spatial transcriptomics of the mouse temporomandibular joint (TMJ) using seqFISH, from the dataset "Spatial Transcriptomics of Mouse CFA-induced TMJ arthritis" https://doi.org/10.25550/8Q-3KAR

FaceBase @facebase.bsky.social · 23/02/2026

It's that time again! Join us for our Office Hours this week: 📅 Wednesday, Feb 25, 1 pm ET / 10 am PT Zoom with FaceBase team members and ask questions about finding data, submitting data, citing data, and more things data! Click here to register: usc.zoom.us/meeting/regi...

FaceBase @facebase.bsky.social · 13/02/2026

New data: microCT datasets from ameloblast-specific Smad4 knockout and Ambn-IRESCre mice. Using a novel ameloblast-restricted Cre line, these data reveal severe enamel-specific pathology and highlight Ambn-IRESCre as a powerful tool for enamel gene function studies: www.facebase.org/2026/02/11/r...

Mutant sample from the dataset MicroCT analysis of ameloblast specific Smad4 conditional knockout mice

FaceBase @facebase.bsky.social · 06/02/2026

Registration and Call for Abstracts are open for the FaceBase 2026 Community Forum! Advances in data reuse, integration, and AI-ready biomedical research in dental, oral, craniofacial, inner ear and related research. 📅 May 4-5, 2026 📍 Arlington, VA (also via Zoom) Register: bit.ly/FBForum2026

Flyer for the FaceBase 2026 Community Forum
Arlington, VA on May 4 & 5, 2026
Advances in data reuse, integration, and AI-ready biomedical research in dental, oral, craniofacial, inner ear and related research.

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FaceBase @facebase.bsky.social · 21/01/2026

New data release: Justin Cotney’s lab - @justincotney.bsky.social - generated a single-nucleus RNA sequencing (snRNA-seq) atlas of critical time points during human and mouse craniofacial development, now openly available through FaceBase. Read all about it here: www.facebase.org/2026/01/20/r...

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FaceBase @facebase.bsky.social · 20/01/2026

Save the dates for the next FaceBase Community Forum: May 4 & 5 2026 in Arlington, VA. More details coming soon! www.facebase.org/community/an...

Save the Dates for the 2026 FaceBase Community Forum in Arlington, VA on: May 4 & 5 2026! For updates, go to:https://bit.ly/FBForum2026

FaceBase @facebase.bsky.social · 12/11/2025

Missed the FaceBase Bootcamp? No worries! Catch up with recordings and slides covering data discovery, submissions, and DMS plans: 🎥 www.facebase.org/community/tr... #FaceBase #DataSharing #CraniofacialResearch #NIH #DentalResearch #DataReuse #FAIRdata #DataScience

Screenshot of the FaceBase Virtual Bootcamp - Fall 2025: Rob Schuler is presenting a slide about how FaceBase data is ready for Reuse, Reproducibility and (Re)analysis.

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FaceBase @facebase.bsky.social · 03/11/2025

Reminder: 📣 Our next virtual bootcamp, tailored for both users and data contributors, is coming up on Wednesday, November 5th! For dental, oral, and craniofacial researchers, clinicians and students: www.facebase.org/community/tr...

FOR DENTAL, ORAL, AND CRANIOFACIAL RESEARCHERS, CLINICIANS AND STUDENTS

FACEBASE BOOTCAMP

(FOR USERS AND CONTRIBUTORS)

LEARN HOW TO MAKE THE MOST OF THE FACEBASE RESOURCE AND BEST PRACTICES FOR MANAGING AND SHARING DATA

Wed, November 5 1:00 pm - 4:00 pm Eastern/ 10:00 am - 1:00 pm Pacific

Online Event

Learn more and register at:

https://www.facebase.org/community/training/2025-11-05/

FaceBase @facebase.bsky.social · 28/10/2025

It's that time again! Join us for our Office Hours tomorrow (Wednesday), 1 pm ET / 10 am PT! Talk with FaceBase team members and ask questions about finding data, submitting data, citing data, and more! Click here to register: usc.zoom.us/meeting/regi...

FaceBase Office Hours
Last Wednesday of the month
10 am PT / 1 pm ET
If you have questions about submitting your data, requesting controlled-access human data, how to best find certain data, or any other aspect of interacting with FaceBase, please join us!

FaceBase @facebase.bsky.social · 28/10/2025

📣 Our next virtual bootcamp, tailored for both users and data contributors, is coming up next week: Wednesday, November 5th! Whether you're a seasoned user of FaceBase or looking to contribute data for the first time, this event is for you! www.facebase.org/community/tr...

OR DENTAL, ORAL AND CRANIOFACIAL RESEARCHERS, CLINICIANS AND STUDENTS

FACEBASE BOOTCAMP

(FOR USERS AND CONTRIBUTORS)

LEARN HOW TO MAKE THE MOST OF THE FACEBASE RESOURCE AND BEST PRACTICES FOR MANAGING AND SHARING DATA

Wed, November 5 1:00 pm - 4:00 pm Eastern/ 10:00 am - 1:00 pm Pacific

Online Event

Learn more and register at:

facebase.org/community/training/

FaceBase @facebase.bsky.social · 13/10/2025

🎉 Congratulations to FaceBase PI, Yang Chai, on his confirmation as Dean of the USC Ostrow School of Dentistry!! @ccmb.usc.edu

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FaceBase @facebase.bsky.social · 08/10/2025

New release on #FaceBase: Timothy C. Cox’s lab - @craniofacialprof.bsky.social - has identified SHROOM3 as a bona fide craniofacial microsomia gene. The mouse embryo imaging data from this study is now openly available through FaceBase. Read all about it here: www.facebase.org/2025/09/15/r...

Shroom3 morphometrics image from Zhu et al 2025

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FaceBase @facebase.bsky.social · 30/09/2025

If you are attending the poster session at the Society for Craniofacial Genetics and Developmental Biology meeting this year, make sure to stop by and say hi to Rob and Alejandro at the FaceBase poster and demo! @scgdb.bsky.social

FaceBase @facebase.bsky.social · 25/09/2025

We're excited to announce a new article about FaceBase at the Node! Check it out!

FaceBase @facebase.bsky.social · 26/08/2025

Join us for our Office Hours tomorrow (Wednesday)! 1-2 pm Eastern / 10-11 am Pacific Meet with FaceBase team members and ask questions about finding data, submitting data, citing data and more! We can also help you fill out your DMS plans! Click here to register: usc.zoom.us/meeting/regi...

usc.zoom.us

Welcome! You are invited to join a meeting: FaceBase Office Hours. After registering, you will receive a confirmation email about joining the meeting.

FaceBase @facebase.bsky.social · 06/08/2025

New releases on #FaceBase: two global orofacial-cleft datasets (OFC1/OFC2) + two Appalachian oral-health-disparity cohorts (COHRA1 & 2). Rich 3-D imaging, genomics & longitudinal surveys ready for discovery. Read all about it here: www.facebase.org/2025/07/28/r...

Images from the Pittsburgh Orofacial Cleft (OFC) Birth Defects Study

Map of diverse populations included in the OFC studies.

Conceptual models of the multidisciplinary studes of COHRA1 and COHRA2

FaceBase @facebase.bsky.social · 29/07/2025

It's that time again for FaceBase Office Hours! This Wednesday (tomorrow!) 1pm Eastern / 10 am Pacific! Meet with FaceBase team members and ask questions about finding data, submitting data, citing data and more! Click here to register on Zoom: usc.zoom.us/meeting/regi...

Nature Portfolio @natureportfolio.nature.com · 09/07/2025

Reposted by FaceBase

It’s been 25 years since the UCSC Genome Browser launched. Nature profiles how the website remains an essential tool for navigating the genome and understanding its structure, function, and clinical impact. #Academicsky 🧬 🧪

go.nature.com

’We couldn’t live without it’: the UCSC Genome Browser turns 25

After a quarter of a century, the website remains an essential tool for navigating the genome and understanding its structure, function and clinical impact.

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FaceBase @facebase.bsky.social · 03/07/2025

Slides, webcasts and posters from the 2025 FaceBase Community Forum are now available on facebase.org. Topics: new collaborations, data integration, AI applications, integrating clinical elements into FaceBase, new technologies, advances in basic research and more! www.facebase.org/community/an...

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FaceBase @facebase.bsky.social · 03/07/2025

Congratulations to our co-PI, Yang Chai, DMD, DDS, PhD, on becoming the next dean of the Herman Ostrow School of Dentistry of USC! @ccmb.usc.edu‬

Photo of Yang Chai, the next dean of the Herman Ostrow School of Dentistry of USC, who is the co-PI of FaceBase.

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Reposted by FaceBase

USC Information Sciences Institute @isi.edu · 04/06/2025

Great first day at the FaceBase 2025 Community Forum, hosted at USC’s Information Sciences Institute! The sessions focused on integrating clinical tools and #AI into #craniofacial pain research, featuring work from USC and UCSF, and poster presentations. @viterbischool.usc.edu @usc.edu

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FaceBase @facebase.bsky.social · 28/05/2025

We are excited to announce another new dataset release on FaceBase from a PLOS Genetics paper about SHH expression in the Frontonasal Ectodermal Zone that depicts a new enhancer element! Learn more here: www.facebase.org/2025/05/21/r...

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FaceBase @facebase.bsky.social · 27/05/2025

🕙 FaceBase Office Hours this Wednesday (tomorrow!) 1pm Eastern / 10 am Pacific! Our monthly Office Hours are an opportunity to meet with FaceBase team members and ask questions about finding data, submitting data, citing data and more! Click here to register on Zoom: usc.zoom.us/meeting/regi...

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FaceBase @facebase.bsky.social · 20/05/2025

FaceBase has released new datasets from a Nature Communications paper on TGF-β Signaling and Craniofacial Morphogenesis with high resolution spatial genomics and scRNA-Seq data! Learn more here: www.facebase.org/2025/05/20/r...

Figure 1 from publication depicting scRNA-Seq data on embryonic mouse palate from stages E12.5 through E18.5 and Spatial Genomics data on embryonic mouse head from histological sections from stages E12.5 through E15.5

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FaceBase @facebase.bsky.social · 15/05/2025

📣 Deadline for abstracts is tomorrow! Quick reminder that if you are planning to present a poster (in-person only) at the FaceBase Community Forum on June 3rd, the deadline to submit your abstract is tomorrow (Friday) May 16! forms.gle/aCanmNj4icgm... #FaceBase2025

Flyer for the FaceBase 2025 Community Forum on June 3 & 4

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FaceBase @facebase.bsky.social · 14/05/2025

Register by Friday, May 16 to attend the FaceBase Community Forum in person — June 3–4 in Marina del Rey, CA! ✅ Register: www.facebase.org/community/an... 📍 Travel info: www.facebase.org/community/an... 📑 Poster Abstract deadline: May 16 📅 Agenda: www.facebase.org/community/an... #FaceBase2025

FaceBase @facebase.bsky.social · 11/04/2025

The FaceBase team had an amazing time at the AADOCR 2025 meeting in New York, engaging with researchers and discussing data-sharing best practices. Our exhibit booth featured live demos, and we enjoyed meeting so many of you in person! #aadocr2025

The FaceBase team at our booth in the AADOCR Exhibit Hall (from left to right: Aref Shafaeibejestan, Alejandro Bugacov, VyVy Nguyen, Cris Williams, Yang Chai, Carl Kesselman, Rob Schuler)

Alejandro Bugacov next to FaceBase's poster and table where he and Rob Schuler provided live demos

Cris Williams and VyVy Nguyen are ready to answer your quesitons about FaceBase!

FaceBase @facebase.bsky.social · 10/04/2025

📣 Reminder to register for the free and public FaceBase Community Forum! Join us on June 3 & 4 in Marina del Rey, CA, for the 2025 Community Forum. For researchers and clinicians studying dental, oral, craniofacial and anatomically relevant diseases and conditions! www.facebase.org/community/an...

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FaceBase @facebase.bsky.social · 24/03/2025

🕙 FaceBase Office Hours this Wednesday 1pm Eastern / 10 am Pacific! Our monthly Office Hours are a great opportunity to meet with FaceBase team members and ask questions about finding data, submitting data, citing data and more! Click here to register on Zoom: usc.zoom.us/meeting/regi...

FaceBase @facebase.bsky.social · 26/02/2025

Reposted by FaceBase

We're looking forward to this year's AADOCR meeting in New York City! You will find us at the Exhibit Hall at Booth 124 March 13-15. Stop by and say hi! Alejandro Bugacov will also make his yearly appearance at the NIDCR Trainee Poster session: Room 1A08 - March 12 9am to 12pm See you IRL soon!

FaceBase @facebase.bsky.social · 07/03/2025

📣 Join us on June 3 & 4 at the Information Sciences Institute (ISI) in Marina del Rey, CA, for the 2025 Community Forum. For members of the dental, oral, and craniofacial research and clinical community and beyond! Register here (free and public): www.facebase.org/community/an...

Mathi Thiruppathy @mathithiru.bsky.social · 07/03/2025

Reposted by FaceBase

Really appreciated this opportunity from @the-node.bsky.social to write about the amazing journey I got to be on for 6 years and the people I met on the way. Every day I feel fortunate to live in and work for a society that chooses to be curious. Now more than ever I hope it continues to do so. ✨

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Reposted by FaceBase

Hannah Long @hannahlong.bsky.social · 14/02/2025

The meeting will focus on genome-wide association studies, aiming to uncover genetic foundations of facial variation. We hope the meeting will foster international and interdisciplinary collaborations and discussions. We especially encourage young and early-career researchers to submit abstracts! 🎤

A flyer for the 3rd International Symposium On Facial Genetics

FaceBase @facebase.bsky.social · 26/02/2025