The R01 grant is the third such NIH award earned by Ostrow researcher and faculty member Dechen Lin, an accomplishment made all the more impressive given the extremely competitive funding environment....

After decades of research, Ostrow faculty member Janet Moradian-Oldak prepares to bring a short peptide that can generate a biomimetic version of tooth enamel to market. FOR DECADES, PROFESSOR JANET M...

A new dataset from the Chai lab at the University of Southern California is now available in FaceBase, combining single-cell RNA sequencing, bulk RNA sequencing, and SeqFISH spatial transcriptomics to...

BackgroundDioxins are persistent environmental pollutants with high lipophilicity and long half-lives, enabling their accumulation in biological tissues and ...

Here, authors show sensory nerve-derived GDF11 coordinates soft palate muscle development and neonatal oropharyngeal function through perimysial signaling.

Sensory innervation of developing organs is influenced by molecular cues secreted from surrounding tissues, yet the mechanisms coordinating this ti...

An epigenetic “mechanostat” has been discovered that protects tooth-forming progenitor cells from mechanical stress and supports lifelong tissue renewal. Using mouse incisors, the study sh...

Bone Research - KDM6B safeguards mineralized tissue homeostasis from mechanical stress through epigenetic control of PIEZO1-mediated mechanotransduction in the mouse incisor

IntroductionFor more than two decades, enamel researchers have primarily used the keratin-14-Cre (Krt14-Cre) driver line to study ameloblast-specific molecul...

Learn more about applying for Assistant Professor of Dentistry at USC

Here they show that TGFβ signaling drives dural cell migration into the coronal suture to maintain its patency. Disruption of this process impairs coronal suture stem cell homeostasis and leads to cra...

Abstract. Transcriptional intratumoral heterogeneity (ITH) is a hallmark of aggressive cancers. Investigation into the ITH programs that drive tumor metastasis and immune evasion could help identify p...

This study reveals how the cBAF chromatin remodeling complex organizes stem cell environments and guides cell fate decisions by recruiting distinct partner proteins to maintain adult tissue homeostasi...

Nature Communications - Here, the authors show that the temporomandibular joint contains a previously unrecognized synovial lymphatic network. Disrupted lymphatics in inflammatory arthritis amplify...

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The clinician-scientist is also the school’s associate dean of research and served as interim dean.

Chan et al. show that enteric neurons influence lipid metabolism in gastric cancer organoids, affecting dependencies on key enzymes. Using CRISPR screening and metabolic analysis, their work highlights how microenvironmental signals impact tumor metabolism and potential treatment targets in gastric cancer.

Our ‘Featured resource’ series aims to shine a light on the resources that support our research – the unsung heroes of the science world. In this post, we learn about the data and functionalities avai...