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FaceBase @facebase.bsky.social · 24/08/2026

It's that time again! Join us for Office Hours this week: 📅 Wednesday, August 26, 1 pm Eastern / 10 am Pacific Ask the FaceBase team about finding, submitting, and citing data. And anything else data! Register: usc.zoom.us/meeting/regi... #craniofacial #OpenData #ScienceSky

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FaceBase @facebase.bsky.social · 04/08/2026

Why do some cranial sutures fuse too early? New FaceBase data point to timing: FGFR2 signaling normally declines after birth, dialing down retinoic acid to keep the coronal suture open. Overactivate it and the suture closes. RNA-Seq, Chai lab, USC. @ccmb.usc.edu www.facebase.org/2026/08/04/r...

FGFR2-RA signaling governs dura mater-suture mesenchyme interaction during early postnatal development to control coronal suture development and craniosynostosis. Illustration created with BioRender.com.

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FaceBase @facebase.bsky.social · 31/07/2026

How do continuously growing teeth withstand constant mechanical load? New FaceBase data identify a KDM6B–BMI1–PIEZO1 "mechanostat" that shields incisor progenitors from stress-induced apoptosis. Bulk RNA-seq + Cut&Run-seq, Chai lab, USC. www.facebase.org/2026/07/30/r...

Schematic representation of KDM6B safeguarding tissue homeostasis to mechanical stress through epigenetic control of PIEZO1- mediated mechanotransduction. Using the mouse incisor as a model of mechanical loading, we reveal that within TACs, Kdm6b demethylates H3K27me3, thereby relieving the repression of the Bmi1 gene. Normal BMI1 inhibits Piezo1 expression. This maintains physiological PIEZO1 levels, ensuring calibrated Ca2+ influx for proliferation and differentiation. In contrast, loss of Kdm6b leads to an accumulation of H3K27me3 at the Bmi1 promoter region, which silences Bmi1 expression and diminishes BMI1 formation. This reduction results in pathologically increased PIEZO1 ion channels in the membrane. The subsequent Ca2+ overload triggers TAC apoptosis while reducing proliferation and differentiation. Ultimately, these molecular events compromise tissue homeostasis. Schematic created with BioRender.com. Ho, T. (2026) https://BioRender.com/8mzv4a

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FaceBase @facebase.bsky.social · 28/07/2026

It's that time again! Join us for our Office Hours tomorrow: 📅 Wednesday, July 29, 1 pm ET / 10 am PT Zoom with FaceBase team members and ask questions about finding data, submitting data, citing data, and more things data! Click here to register: usc.zoom.us/meeting/regi...

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FaceBase @facebase.bsky.social · 15/07/2026

Save the date! The 2027 FaceBase Community Forum heads to Los Angeles — April 27–28, 2027, at USC/ISI in Marina del Rey. Details soon: bit.ly/FBForum2027

Save the Date Flyer with navy and gold highlights displaying initial details for the 2027 FaceBase Community Forum: April 27 & 28, 2027 at USC Information Sciences Institute, 4676 Admiralty Way, Marina del Rey, CA. Inviting: researchers, clinicians, data scientists trainees. Focused on: dental, oral, craniofacial, inner ear and related health domains. More details coming soon. Check for updates at: https://bit.ly/FBForum2027

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FaceBase @facebase.bsky.social · 20/04/2026

We've extended the poster abstract deadline for the 2026 FaceBase Annual Meeting! Share your work and connect with the craniofacial research community. Deadline is now: Friday, April 24. Submit here → facebase.org/community/annual-meeting/2026-facebase-annual/abstracts/

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FaceBase @facebase.bsky.social · 14/04/2026

📋 A few days left to submit a poster abstract for the 2026 FaceBase Annual Meeting! Share your work and connect with the craniofacial research community. Deadline: Friday, April 17. Submit here → facebase.org/community/annual-meeting/2026-facebase-annual/abstracts/

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FaceBase @facebase.bsky.social · 10/04/2026

New on FaceBase 🧬 A new dataset from Ma & Rosin examines how prenatal depletion of CSF1R+ macrophages and osteoclasts disrupts craniofacial development — with effects on the skull, mandible, palate, ear ossicles, and more. Dataset + publication now available. www.facebase.org/2026/04/09/r...

An example one of the PLX5622 treated P1 skulls. Image by Felix Ma and Jessica M. Rosin.

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FaceBase @facebase.bsky.social · 20/03/2026

Will you be at AADOCR/IADR or GRC next week? FaceBase will be in Ventura and San Diego with demos, presentations, and opportunities to connect with our team. See where to find us! www.facebase.org/2026/03/19/f...

A view of the San Diego Convention Center, where the AADOCR/IADR will be held next week. See FaceBase in Booth 402!

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FaceBase @facebase.bsky.social · 05/03/2026

New data: Spatial transcriptomics (using seqFISH) reveals a fibroblast-immune microenvironment remodeling pathway in CFA-induced TMJ arthritis in mice. PI: Jian-Fu Chen (University of Southern California) doi.org/10.25550/8Q-...

Spatial transcriptomics of the mouse temporomandibular joint (TMJ) using seqFISH, from the dataset "Spatial Transcriptomics of Mouse CFA-induced TMJ arthritis" https://doi.org/10.25550/8Q-3KAR

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FaceBase @facebase.bsky.social · 23/02/2026

It's that time again! Join us for our Office Hours this week: 📅 Wednesday, Feb 25, 1 pm ET / 10 am PT Zoom with FaceBase team members and ask questions about finding data, submitting data, citing data, and more things data! Click here to register: usc.zoom.us/meeting/regi...

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FaceBase @facebase.bsky.social · 13/02/2026

New data: microCT datasets from ameloblast-specific Smad4 knockout and Ambn-IRESCre mice. Using a novel ameloblast-restricted Cre line, these data reveal severe enamel-specific pathology and highlight Ambn-IRESCre as a powerful tool for enamel gene function studies: www.facebase.org/2026/02/11/r...

Mutant sample from the dataset MicroCT analysis of ameloblast specific Smad4 conditional knockout mice

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FaceBase @facebase.bsky.social · 06/02/2026

Registration and Call for Abstracts are open for the FaceBase 2026 Community Forum! Advances in data reuse, integration, and AI-ready biomedical research in dental, oral, craniofacial, inner ear and related research. 📅 May 4-5, 2026 📍 Arlington, VA (also via Zoom) Register: bit.ly/FBForum2026

Flyer for the FaceBase 2026 Community Forum
Arlington, VA on May 4 & 5, 2026
Advances in data reuse, integration, and AI-ready biomedical research in dental, oral, craniofacial, inner ear and related research.

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FaceBase @facebase.bsky.social · 21/01/2026

New data release: Justin Cotney’s lab - @justincotney.bsky.social - generated a single-nucleus RNA sequencing (snRNA-seq) atlas of critical time points during human and mouse craniofacial development, now openly available through FaceBase. Read all about it here: www.facebase.org/2026/01/20/r...

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FaceBase @facebase.bsky.social · 20/01/2026

Save the dates for the next FaceBase Community Forum: May 4 & 5 2026 in Arlington, VA. More details coming soon! www.facebase.org/community/an...

Save the Dates for the 2026 FaceBase Community Forum in Arlington, VA on: May 4 & 5 2026! For updates, go to:https://bit.ly/FBForum2026

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FaceBase @facebase.bsky.social · 12/11/2025

Missed the FaceBase Bootcamp? No worries! Catch up with recordings and slides covering data discovery, submissions, and DMS plans: 🎥 www.facebase.org/community/tr... #FaceBase #DataSharing #CraniofacialResearch #NIH #DentalResearch #DataReuse #FAIRdata #DataScience

Screenshot of the FaceBase Virtual Bootcamp - Fall 2025: Rob Schuler is presenting a slide about how FaceBase data is ready for Reuse, Reproducibility and (Re)analysis.

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FaceBase @facebase.bsky.social · 03/11/2025

Reminder: 📣 Our next virtual bootcamp, tailored for both users and data contributors, is coming up on Wednesday, November 5th! For dental, oral, and craniofacial researchers, clinicians and students: www.facebase.org/community/tr...

FOR DENTAL, ORAL, AND CRANIOFACIAL RESEARCHERS, CLINICIANS AND STUDENTS

FACEBASE BOOTCAMP

(FOR USERS AND CONTRIBUTORS)

LEARN HOW TO MAKE THE MOST OF THE FACEBASE RESOURCE AND BEST PRACTICES FOR MANAGING AND SHARING DATA

Wed, November 5 1:00 pm - 4:00 pm Eastern/ 10:00 am - 1:00 pm Pacific

Online Event

Learn more and register at:

https://www.facebase.org/community/training/2025-11-05/

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FaceBase @facebase.bsky.social · 28/10/2025

It's that time again! Join us for our Office Hours tomorrow (Wednesday), 1 pm ET / 10 am PT! Talk with FaceBase team members and ask questions about finding data, submitting data, citing data, and more! Click here to register: usc.zoom.us/meeting/regi...

FaceBase Office Hours
Last Wednesday of the month
10 am PT / 1 pm ET
If you have questions about submitting your data, requesting controlled-access human data, how to best find certain data, or any other aspect of interacting with FaceBase, please join us!

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FaceBase @facebase.bsky.social · 28/10/2025

📣 Our next virtual bootcamp, tailored for both users and data contributors, is coming up next week: Wednesday, November 5th! Whether you're a seasoned user of FaceBase or looking to contribute data for the first time, this event is for you! www.facebase.org/community/tr...

OR DENTAL, ORAL AND CRANIOFACIAL RESEARCHERS, CLINICIANS AND STUDENTS

FACEBASE BOOTCAMP

(FOR USERS AND CONTRIBUTORS)

LEARN HOW TO MAKE THE MOST OF THE FACEBASE RESOURCE AND BEST PRACTICES FOR MANAGING AND SHARING DATA

Wed, November 5 1:00 pm - 4:00 pm Eastern/ 10:00 am - 1:00 pm Pacific

Online Event

Learn more and register at:

facebase.org/community/training/

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FaceBase @facebase.bsky.social · 08/10/2025

New release on #FaceBase: Timothy C. Cox’s lab - @craniofacialprof.bsky.social - has identified SHROOM3 as a bona fide craniofacial microsomia gene. The mouse embryo imaging data from this study is now openly available through FaceBase. Read all about it here: www.facebase.org/2025/09/15/r...

Shroom3 morphometrics image from Zhu et al 2025

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FaceBase @facebase.bsky.social · 30/09/2025

If you are attending the poster session at the Society for Craniofacial Genetics and Developmental Biology meeting this year, make sure to stop by and say hi to Rob and Alejandro at the FaceBase poster and demo! @scgdb.bsky.social

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FaceBase @facebase.bsky.social · 06/08/2025

New releases on #FaceBase: two global orofacial-cleft datasets (OFC1/OFC2) + two Appalachian oral-health-disparity cohorts (COHRA1 & 2). Rich 3-D imaging, genomics & longitudinal surveys ready for discovery. Read all about it here: www.facebase.org/2025/07/28/r...

Images from the Pittsburgh Orofacial Cleft (OFC) Birth Defects Study

Map of diverse populations included in the OFC studies.

Conceptual models of the multidisciplinary studes of COHRA1 and COHRA2

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FaceBase @facebase.bsky.social · 29/07/2025

It's that time again for FaceBase Office Hours! This Wednesday (tomorrow!) 1pm Eastern / 10 am Pacific! Meet with FaceBase team members and ask questions about finding data, submitting data, citing data and more! Click here to register on Zoom: usc.zoom.us/meeting/regi...

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FaceBase @facebase.bsky.social · 03/07/2025

Slides, webcasts and posters from the 2025 FaceBase Community Forum are now available on facebase.org. Topics: new collaborations, data integration, AI applications, integrating clinical elements into FaceBase, new technologies, advances in basic research and more! www.facebase.org/community/an...

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FaceBase @facebase.bsky.social · 03/07/2025

Congratulations to our co-PI, Yang Chai, DMD, DDS, PhD, on becoming the next dean of the Herman Ostrow School of Dentistry of USC! @ccmb.usc.edu‬

Photo of Yang Chai, the next dean of the Herman Ostrow School of Dentistry of USC, who is the co-PI of FaceBase.

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FaceBase @facebase.bsky.social · 28/05/2025

We are excited to announce another new dataset release on FaceBase from a PLOS Genetics paper about SHH expression in the Frontonasal Ectodermal Zone that depicts a new enhancer element! Learn more here: www.facebase.org/2025/05/21/r...

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FaceBase @facebase.bsky.social · 20/05/2025

FaceBase has released new datasets from a Nature Communications paper on TGF-β Signaling and Craniofacial Morphogenesis with high resolution spatial genomics and scRNA-Seq data! Learn more here: www.facebase.org/2025/05/20/r...

Figure 1 from publication depicting scRNA-Seq data on embryonic mouse palate from stages E12.5 through E18.5 and Spatial Genomics data on embryonic mouse head from histological sections from stages E12.5 through E15.5

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FaceBase @facebase.bsky.social · 15/05/2025

📣 Deadline for abstracts is tomorrow! Quick reminder that if you are planning to present a poster (in-person only) at the FaceBase Community Forum on June 3rd, the deadline to submit your abstract is tomorrow (Friday) May 16! forms.gle/aCanmNj4icgm... #FaceBase2025

Flyer for the FaceBase 2025 Community Forum on June 3 & 4

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FaceBase @facebase.bsky.social · 14/05/2025

Register by Friday, May 16 to attend the FaceBase Community Forum in person — June 3–4 in Marina del Rey, CA! ✅ Register: www.facebase.org/community/an... 📍 Travel info: www.facebase.org/community/an... 📑 Poster Abstract deadline: May 16 📅 Agenda: www.facebase.org/community/an... #FaceBase2025

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FaceBase @facebase.bsky.social · 11/04/2025

The FaceBase team had an amazing time at the AADOCR 2025 meeting in New York, engaging with researchers and discussing data-sharing best practices. Our exhibit booth featured live demos, and we enjoyed meeting so many of you in person! #aadocr2025

The FaceBase team at our booth in the AADOCR Exhibit Hall (from left to right: Aref Shafaeibejestan, Alejandro Bugacov, VyVy Nguyen, Cris Williams, Yang Chai, Carl Kesselman, Rob Schuler)

Alejandro Bugacov next to FaceBase's poster and table where he and Rob Schuler provided live demos

Cris Williams and VyVy Nguyen are ready to answer your quesitons about FaceBase!

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FaceBase @facebase.bsky.social · 10/04/2025

📣 Reminder to register for the free and public FaceBase Community Forum! Join us on June 3 & 4 in Marina del Rey, CA, for the 2025 Community Forum. For researchers and clinicians studying dental, oral, craniofacial and anatomically relevant diseases and conditions! www.facebase.org/community/an...

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FaceBase @facebase.bsky.social · 24/03/2025

🕙 FaceBase Office Hours this Wednesday 1pm Eastern / 10 am Pacific! Our monthly Office Hours are a great opportunity to meet with FaceBase team members and ask questions about finding data, submitting data, citing data and more! Click here to register on Zoom: usc.zoom.us/meeting/regi...

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FaceBase @facebase.bsky.social · 07/03/2025

📣 Join us on June 3 & 4 at the Information Sciences Institute (ISI) in Marina del Rey, CA, for the 2025 Community Forum. For members of the dental, oral, and craniofacial research and clinical community and beyond! Register here (free and public): www.facebase.org/community/an...

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