iiinova — where your digital self keeps evolving

Reposted by Justin Cotney

Noonan Lab @noonanlab.bsky.social · 14/09/2026

New preprint from the lab! Using a humanized mouse model, we found that a Human Accelerated Region drives heterochronic changes in craniofacial and limb development (apologies for the re-post, we needed to adjust the thread a bit): www.biorxiv.org/content/10.6...

biorxiv.org

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Reposted by Justin Cotney

Alek Erickson @alekerickson.bsky.social · 24/08/2026

We are still seeking a postdoc experienced in dev bio to join our lab for a project investigating the epigenetic regulation of cell fate in the early face. Deadline for this call is in few days, so please share this post. www.su.se/download/18....

su.se

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Reposted by Justin Cotney

Evgeny Kvon @evgenykvon.bsky.social · 25/08/2026

First synthetic mouse enhancers active in defined embryonic tissues! Great collaboration led by @alex-stark.bsky.social lab now at @natgenet.nature.com

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Justin Cotney @justincotney.bsky.social · 02/07/2026

this is so well done! both hilarious and sad simultaneously

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Reposted by Justin Cotney

Jonas Koeppel @jonaskoeppel.bsky.social · 04/06/2026

1/n What fraction of the human genome is essential for cells? Excited to share our preprint that explores this question by combining an unusual CRISPR system, phage promoters, and thousands of deletion launchpads. @sudpinglay.bsky.social @jshendure.bsky.social www.biorxiv.org/content/10.6...

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Reposted by Justin Cotney

Evgeny Kvon @evgenykvon.bsky.social · 09/04/2025

A tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo www.nature.com/articles/s41...

nature.com

DNA-guided transcription factor interactions extend human gene regulatory code - Nature

A large-scale analysis of DNA-bound transcription factors (TFs) shows how the presence of DNA markedly affects the landscape of TF interactions, and identifies composite motifs that are recognized by ...

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Justin Cotney @justincotney.bsky.social · 21/01/2025

Happy to present the first preprint from my lab after relocating @CHOP_Research @ChildrensPhila Here we describe gene expression at the single cell level across major milestones of human and mouse development. preprint here: buff.ly/3PFWNoG

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Reposted by Justin Cotney

Jesse Engreitz @jengreitz.bsky.social · 20/11/2024

Impressive study from Alex Stark lab identifying 3 new types of silencer elements in Drosophila New TF binds a particular isolated motif in non-accessible sites to recruit G9a. Deletion of these elements can lead to upregulation of nearby gene www.sciencedirect.com/science/arti...

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