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Mathi Thiruppathy

@mathithiru.bsky.social
102 followers 182 following 11 posts
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Reposted by Mathi Thiruppathy
Katie Mack @astrokatie.com · 03/10/2025
I think for me the most compelling answer for "why fund basic research?" (and the one most relevant to the people doing the work) is that humans are curious and finding stuff out makes us happy and fulfilled. Science is a thing humans like. Life would be more dull and sad if we didn't do it. end/🧵
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Mathi Thiruppathy @mathithiru.bsky.social · 04/09/2025
🤯
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Reposted by Mathi Thiruppathy
Evgeny Kvon @evgenykvon.bsky.social · 02/07/2025
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
nature.com
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
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Reposted by Mathi Thiruppathy
Evgeny Kvon @evgenykvon.bsky.social · 23/06/2025
How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/
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Mathi Thiruppathy @mathithiru.bsky.social · 13/06/2025
😍 So much fascinating development in this system. These images and movies do justice to how beautiful and complex fish gills are.
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Reposted by Mathi Thiruppathy
Mathieu Preußner @mathpreu.bsky.social · 25/04/2025
-A Gill's Secret Sidekick - A small, often-overlooked organ tucked behind the eye. In zebrafish, the pseudobranch arises from mandibular arch mesenchyme — the same region that forms jaws — and shares gene expression and developmental programs with true gills. 🔬 #FluorescenceFriday #zebrafish
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Mathieu Preußner @mathpreu.bsky.social · 11/04/2025
Gills just wanna have #FluorescenceFriday 🎵 Phalloidin reveals the beauty of the filament's distal tip in cleared gills of adult 🦓🐟 #microscopy #devbio #sciart
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Mathi Thiruppathy @mathithiru.bsky.social · 12/03/2025
Gorgeous gills. 😍
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Mathi Thiruppathy @mathithiru.bsky.social · 07/03/2025
Really appreciated this opportunity from @the-node.bsky.social to write about the amazing journey I got to be on for 6 years and the people I met on the way. Every day I feel fortunate to live in and work for a society that chooses to be curious. Now more than ever I hope it continues to do so. ✨
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Reposted by Mathi Thiruppathy
Rita Strack @ritastrack.bsky.social · 06/02/2025
"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...
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Reposted by Mathi Thiruppathy
Development @dev-journal.bsky.social · 22/01/2025
Sox10 is required for systemic initiation of bone mineralization Read this #OpenAccess Research Article by Stefani Gjorcheska, Lindsey Barske & co. @cincyresearch.bsky.social : journals.biologists.com/dev/article…
Figure 1 (A) Example images illustrating a major delay in initiation of bone mineralization in sox10 mutants between 3 and 7 dpf revealed by Alizarin Red staining. Some mineralization is present by 5 dpf but never achieves control levels before lethality at 8 dpf.
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Nadav Ahituv @nadavahituv.bsky.social · 15/01/2025
Massively parallel reporter assays (MPRAs) testing >680,000 sequences combined with machine learning to improve regulatory element & variant effect prediction. Amazing work by @vagar.bsky.social, Fumitaka Inoue, @jshendure.bsky.social and many others as part of ENCODE. www.nature.com/articles/s41...
nature.com
Massively parallel characterization of transcriptional regulatory elements - Nature
Lentivirus-based reporter assays for 680,000 regulatory sequences from three cell lines coupled to machine-learning models lead to insights into the grammar of cis-regulatory elements.
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Mathi Thiruppathy @mathithiru.bsky.social · 09/01/2025
Excited to share this story from my PhD revealing the surprising legacy of our gill-bearing ancestry in the form of our cartilaginous outer ears, summarized in this series of Tweets.
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