Reconstructing parental haplotypes for up to 440,209 UK and Estonian Biobank participants, the authors estimate genetic assortative mating across 69 traits and find that assortment for height and educ...

Primary psychotic disorders (PPD) and bipolar disorder (BD) are characterised by recurrent episodes, long-term pharmacological treatment, and a strong polygenic component. Although clinical trials rem...

Abstract. Investigating the genetic architecture of complex diseases is challenging due to the multifactorial interplay of genomic and environmental influe

Background Understanding interindividual variability in medication dosing is central to precision medicine. Despite significant pharmacogenomic (PGx) insights into key biological pathways influencing ...

European Journal of Human Genetics - Genetic influences on antidepressant side effects: a CYP2C19 gene variation and polygenic risk study in the Estonian Biobank

Large-scale biobanks have become a font of data that have led to discoveries across many fields of research. Here, the authors provide an overview of the Estonian Biobank, highlighting its value for r...

Despite significant pharmacogenomic (PGx) insights into key biological pathways influencing drug response, the polygenic contribution to dose variability and the potential of electronic health records...

Scientific Reports - Pathway level metabolomics analysis identifies carbon metabolism as a key factor of incident hypertension in the Estonian Biobank

This study provides a cross-trait atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses.

Parent-of-origin effects (POEs) occur when the impact of a genetic variant depends on its parental origin. Traditionally linked to genomic imprinting, these effects are believed to have evolved from p...

The host genetics of SARS-CoV-2 has previously been studied based on cases from the earlier waves of the pandemic in 2020 and 2021, identifying 51 genomic loci associated with infection and/or severit...