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Eric Paulissen

@ericpaulissen.bsky.social
215 followers 382 following 3 posts

Postdoc in the Crump lab. Interested in vertebrate body plans and stem cell biology.

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Reposted by Eric Paulissen
Igor Adameyko @adameykolab.bsky.social · 25/09/2026
Research Briefings about our paper in Nature Genetics (atlas of human facial development): www.nature.com/articles/s41....
nature.com
Human facial development atlas illuminates enhancer-based control of facial individuality - Nature Genetics
The facial skeleton is essential for eating, breathing, kissing, speech and personal identity. Our spatiotemporally resolved cell atlas of human embryonic craniofacial development will facilitate a de...
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Ben Williamson @benpatrickwill.bsky.social · 18/07/2026
The anatomy of an AI-supported academic article is becoming more apparent. I desk reviewed ~70 manuscripts this week for our journal. Reckon 20ish had significant AI assistance. On top of hundreds of others recently I'm starting to see patterns. Are other editors are seeing the same or similar? 1/
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Taylor Black @taylorblack.bsky.social · 01/07/2026
A fish that can drop a beat?!? The freshwater drum(Aplodinotus grunniens) and its saltwater relatives make drumming sounds by rapidly contracting muscles against a specialized swim bladder. Rock on 🥁 #SciComm #illustration #fish #SciArt #ichthyology
A handmade illustration of a freshwater drum.
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RC Hoover @rchoover.bsky.social · 16/05/2026
My first PhD chapter is out! How do related fishes adapt to eat different foods? And how do they change as they grow? 🧵 doi.org/10.1002/jmor...
Screenshot of https://doi.org/10.1002/jmor.70131
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James Gagnon @james-gagnon.bsky.social · 28/04/2026
Using light-activated CRISPR in zebrafish, we triggered synchronized DNA breaks and track the repair process. ⚡🐟⚡ 

 Well ... DNA repair is very different in embryos compared to tissue culture cells. Embryos repair DNA breaks incredibly fast - within minutes! www.biorxiv.org/content/10.6...
A cartoon showing how a caged guide RNA poises CRISPR cleavage until release by light. Below, a cartoon of injection of "light-activated CRISPR" into the embryo, followed by activation.
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Eric Paulissen @ericpaulissen.bsky.social · 11/04/2026
Hey, craniofacial and development folks! Check out a new preprint from me and @crumplab.bsky.social about the developing jaw. Here, we show how major signaling pathways establish distinct compartments along the oral-aboral axis. I'm excited to share it with you all!
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bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · 05/01/2026
Real-time single-molecule imaging in zebrafish embryos uncovers non-canonical translation www.biorxiv.org/content/10.64898/20…
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Evgeny Kvon @evgenykvon.bsky.social · 24/12/2025
Not that long ago, in vivo mouse enhancer design was a dream. Today, it's a reality! Using transfer deep learning to design de novo synthetic embryonic enhancers active in the heart, limb, and CNS. Great collab with @alex-stark.bsky.social lab! @ucibiosci.bsky.social @impvienna.bsky.social
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Dave Matus @davematus.bsky.social · 05/12/2025
We need to build lots of new transgenic lines that are both very bright and photostable, so I was excited to test membrane fusions of the three published mStayGold variants compared to mNeonGreen. We injected mRNA into zebrafish embryos and imaged at 24hpf. 2/7
single confocal images comparing mNG vs. mStayGold
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Society for Developmental Biology @socdevbio.bsky.social · 01/12/2025
🎄 Day 1 of the 24 Days of Development ✨🧬 This study shows how different fixation methods (PFA vs. TCA) change what researchers can visualize in chicken embryos using HCR or IHC. 🔍🐣🔬 doi.org/10.1016/j.yd...
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Development @dev-journal.bsky.social · 21/11/2025
Midline tissue formation in zebrafish development This Research Highlight showcases the work from Robert Morabito, Benjamin Martin (@blmartin.bsky.social) and colleagues @stonybrooku.bsky.social : journals.biologists.com/dev/article/...
Figure 6 - Changing the Wnt:sox2 ratio prevents the dorsal midline NMP to notochord transition. (A-B‴) Transplanting wild-type (WT) rhodamine dextran-labeled cells into the midline progenitor region of host embryos shows transplanted cells contributing to both the floor plate and notochord (A-A‴; red boxes in A and A″ show regions in A′ and A‴, respectively; n=7; all show donor contribution to both notochord and floor plate). When the sox2 level is elevated in transplanted cells, using the HS:sox2 transgenic line, cells stay in the dorsal midline progenitor zone but fail to generate notochord (B-B‴; red boxes in B and B″ show regions in B′ and B‴, respectively; n=11; 11/11 show contribution of donor cells to the floor plate, 7/11 show complete lack of donor cells in notochord after heat-shock induction, 4/11 show a minor amount of notochord contribution at the very posterior tip of the notochord; see Fig. S7).
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Evan Bardot (he/him) @ebardot.bsky.social · 15/10/2025
Lots of great discussion about developmental variability here at #GastrulationReloaded! Super important to consider, and current tools have the power for this. Related to this recent paper showing that mild phenotypes are more variable than severe ones. www.nature.com/articles/s41...
nature.com
A quadratic paradigm describes the relationship between phenotype severity and variation - Nature Communications
Phenotype variation is higher in mutants than wild types. Examining a range of mutant severities, this study unexpectedly found that variation decreases in severe conditions. A quadratic trend best fi...
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 08/10/2025
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died. Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology. More: www2.mrc-lmb.cam.ac.uk/john-gurdon-... #LMBNews
Black and white portrait of John Gurdon, 1971
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Piali Sengupta @senguptalab.bsky.social · 15/09/2025
A huge shoutout to all the dedicated grants management specialists at the NIH who are working around the clock to push grants out before the Sep 30 deadline. And also to the POs responding to frantic emails. Not an easy job under the best of circumstances and right now it's the pits. Thank you!
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Cynthia Wolberger @cwolberger.bsky.social · 08/09/2025
A giant in molecular biology and virology has passed. RIP David Baltimore. www.nytimes.com/2025/09/07/s...
nytimes.com
David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87
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Developmental Biology @devbiol.bsky.social · 02/09/2025
#DBfeature Loss of KAT6B causes premature ossification and promotes osteoblast differentiation during development by Maria Bergamasco, Jacqueline Ogier, Alexandra Garnham, Lachlan Whitehead, Kelly Rogers, Gordon Smyth, Rachel Burt, Anne Voss, Tim Thomas tiom33.short.gy/DB520,141-154
Skeletal preps and microCT imaging of mice skulls that are heterozygous or homozygous for Kat6b deletion
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Katherine W. Rogers @katwrog.bsky.social · 21/04/2025
Happy to share a new preprint from my lab! We characterize the on/off kinetics, light dosage-dependence, and more for a suite of optogenetic signaling activators in zebrafish embryos 💡 www.biorxiv.org/content/10.1...
biorxiv.org
An optogenetic toolkit for robust activation of FGF, BMP, and Nodal signaling in zebrafish
Cell signaling regulates a wide range of biological processes including development, homeostasis, and disease. Accessible technologies to precisely manipulate signaling have important applications in ...
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USC Stem Cell @stemcell.keck.usc.edu · 07/04/2025
Congratulations to Gage Crump, professor and vice-chair of the Department of Stem Cell Biology and Regenerative Medicine and Stem Cell Research @keck.usc.edu on receiving the 2025 USC Provost Mentoring Award! @crumplab.bsky.social @stemcell.keck.usc.edu stemcell.keck.usc.edu/gage-crump-r...
Gage Crump
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Jeff Bush @jeffbush.bsky.social · 28/03/2025
Congratulations to Camilla Teng, for winning the "Platform presentation SDB prize" for post-docs at the Northwest SDB meeting, which sounds like it was a fantastic meeting! Camilla will be on the faculty job market soon, so look out for her! @socdevbio.bsky.social @ctbatucsf.bsky.social
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Crump Lab @crumplab.bsky.social · 09/01/2025
The outer ear is a mammalian innovation but where did it come from? In our study in Nature, Mathi Thiruppathy and colleagues find that the outer ear arose from modification of an ancestral gill program first originating in marine invertebrates. www.nature.com/articles/s41... 1/n
nature.com
Repurposing of a gill gene regulatory program for outer ear evolution - Nature
Nature - Repurposing of a gill gene regulatory program for outer ear evolution
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Laurent Formery @laurentformery.bsky.social · 24/12/2024
Time to recycle this xmas brittle star HCR ⭐ Happy holidays all!! ❄️🎁🎄 Stay tuned for some more brittle star data coming soon 😎 #fluorescence #microscopy #HCR #holidays #imaging
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Crump Lab @crumplab.bsky.social · 13/12/2024
How can some vertebrates naturally recover from deafness? In work in PNAS, Tuo Shi finds that enhancers for sensory genes remain open but silent in sister cells of zebrafish and lizards, allowing these to make new inner ear sensory hair cells upon damage. www.pnas.org/doi/10.1073/...
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Crump Lab @crumplab.bsky.social · 12/12/2024
Congratulations to newly minted PhD Tuo Shi. Some exciting news from Tuo is imminent. Stay tuned!
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MwahahahahahadScientist @mads100tist.bsky.social · 02/12/2024
This from Liberali and Schier (2024) @priscaliberali.bsky.social @schierlab.bsky.social is just some of the things basic research in Developmental Biology alone has allowed since 1974. Fund basic research. Push back against anti-science nonsense pubmed.ncbi.nlm.nih.gov/38906136/
A series of discoveries that were made possible by developmental biologists since 1974. See Table 1 of the linked article for the full listContinuation of Table 1 from the linked article
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John Wallingford @jbwallingford.bsky.social · 27/11/2024
Looking for something fun to read? Here’s a #popsci piece I did on the crazy history of cilia and left/right patterning in embryos. Remember #devbiolwriteclub Bluesky Boot Camp starts Monday Dec. 2! Please RS (re-skeet?) nautil.us/the-anatomic...
nautil.us
The Anatomical Quirk That Saved Dr. No
A wild tale of how scientists unraveled embryology's most fascinating mystery.
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