New in Science from Sho Aki, Julien Prudent & colleagues: Golgi-derived vesicles control mitochondrial shape through a lipid switch. PI(4)P vesicles mark fission; class II PI3-kinases convert them to PI(3,4)P2 vesicles that drive fusion.
doi.org/10.1126/scie...
doi.org
Golgi-derived vesicles containing PI(3,4)P2 drive mitochondrial fusion
Mitochondria are dynamic organelles that remodel their shape to regulate cell fate. Mitochondrial division involves interactions with the endoplasmic reticulum (ER), lysosomes, and trans-Golgi network...