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Dr Ellen Knuepfer

@eknuepfer.bsky.social
91 followers 53 following 14 posts

Molecular Parasitologist and vaccinologist, Royal Veterinary College, London

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Reposted by Dr Ellen Knuepfer
The Francis Crick Institute @crick.ac.uk · 23/03/2026
“I think it’s a real mistake to forget where the pipeline for all this begins.” John Diffley reflects on the importance of basic research, his mission to decode DNA replication and recreate it in the lab, and the scientific optimism of the 1960s that helped shape it. www.crick.ac.uk/news/2026-03...
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Reposted by Dr Ellen Knuepfer
Matt Higgins @parasitematt.bsky.social · 03/03/2026
This immunogen is cheap and easy to produce and elicits a high quality antibody response. Project led by @nawsadalam. Read all about it: link.springer.com/article/10.1...
link.springer.com
Structure-guided design of a PfCyRPA-based vaccine against blood-stage malaria - EMBO Molecular Medicine
Effective vaccines against malaria are urgently required. All components of the PfPCRCR complex are essential for erythrocyte invasion by Plasmodium falciparum and are potential vaccine immunogens aga...
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Reposted by Dr Ellen Knuepfer
Katlijn De Meulenaere @katlijndm.bsky.social · 11/02/2026
New work out, with webtool to compare P. #knowlesi and P. #vivax temporal expression of the IDC (orthologs, or any gene of interest)🔥🔥 Reconfirming the suitability of Pk A1H1 as a model for Pv!
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Reposted by Dr Ellen Knuepfer
Imperial Life Sciences @imperiallifesci.bsky.social · 04/02/2026
New PNAS study identifies ESBX, a protein controlling which surface coat gene is active in sleeping sickness parasites - key to immune evasion. @tiengwe-tryplab.bsky.social @zephyris-science.bsky.social @fariatrypslab.bsky.social www.imperial.ac.uk/news/article...
imperial.ac.uk
Scientists reveal how sleeping sickness parasites control their surface coat
Researchers have revealed how parasites hide thousands of antigens behind a single-colour coat and how disrupting this control could make the parasit...
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Dr Ellen Knuepfer @eknuepfer.bsky.social · 03/02/2026
Are you a highly motivated molecular parasitologist excited to study how Plasmodium parasites invade red blood cells? Come and join our collaborative Wellcome Trust-funded project! We have two 3-year postdoc positions available. 👇🏻 jobs.rvc.ac.uk/Vacancy.aspx...
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Reposted by Dr Ellen Knuepfer
Melissa Hart @melissa-natalie.bsky.social · 28/01/2026
Excited about parasites? Love watching movies? Come join our Wellcome-funded project! Parasitology friends, please do share far and wide.
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Reposted by Dr Ellen Knuepfer
Matt Higgins @parasitematt.bsky.social · 18/01/2026
Check out our latest study on the PfRIPR protein, essential for the malaria parasite to get inside our blood cells. We show how antibodies block the function of PfRIPR by preventing its flexible hinges from bending, or by stopping it from compacting as part of its mechanism.
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Dr Ellen Knuepfer @eknuepfer.bsky.social · 17/09/2025
Here is hoping that been given a new opportunity, finally, the courage is there within the directive of the Royal Society to do the right thing.
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Reposted by Dr Ellen Knuepfer
Helen Price @helenpprice.bsky.social · 13/09/2025
A reminder that Elon Musk is still a Fellow of the Royal Society. Surely THIS is the point at which he is expelled @royalsociety.org
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Dr Ellen Knuepfer @eknuepfer.bsky.social · 29/07/2025
Happy to share that the #KnuepferLab has initiated change in culture at the #RoyalVeterinaryCollege as the first lab to participate in the lab sustainability challenge, LEAF. Onwards and upwards!
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Reposted by Dr Ellen Knuepfer
bishara marzook @ghostpathogen.bsky.social · 24/07/2025
Our paper has finally graduated from pre-print to peer-reviewed, pretty much unscathed, and is out now! www.cell.com/cell/fulltex...
cell.com
The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment
An arrayed microscopy-based CRISPR screen revealed host genes affecting multiple infection phenotypes of the intracellular parasite Cryptosporidium. Hits in the host cholesterol biosynthesis pathway a...
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Reposted by Dr Ellen Knuepfer
Joanna Young @youngtoxolab.bsky.social · 08/07/2025
Postdoc position open to investigate chronic Toxoplasma infection! elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
elxw.fa.em3.oraclecloud.com
Postdoctoral Research Associate
We are looking for a talented and enthusiastic Postdoctoral researcher to join the Young lab to investigate secreted proteins during chronic Toxoplasma gondii infection.
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Dr Ellen Knuepfer @eknuepfer.bsky.social · 13/06/2025
Fantastic discovery. Beautiful work! Well done the whole international team. @parasitematt.bsky.social When are you coming to the RVC to give a talk now @sam-chamberlain.bsky.social ?
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Reposted by Dr Ellen Knuepfer
Moritz Treeck @moritztreeck.bsky.social · 03/06/2025
GIMM PhD Programme now open. 17 PhD positions and a few more to come. gimm.pt/course/phd-p...
gimm.pt
GIMM PhD Studentships 2025 – GIMMGIMM PhD Studentships 2025 – GIMM
Thank you very much for your generous donation and for sharing your testimony.We hope to more people feel inspired to join this mission of discovery and innovation!
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Reposted by Dr Ellen Knuepfer
Matt Higgins @parasitematt.bsky.social · 03/06/2025
Looking for a fully-funded D. Phil. / Ph.D. studentship in structural biology and vaccinology? Come to join our team. Fully and generously funded by a donation from the Kyner-Field family with full fees at overseas level. Join us! www.bioch.ox.ac.uk/studentships
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Reposted by Dr Ellen Knuepfer
Matt Higgins @parasitematt.bsky.social · 01/06/2025
Nawsad presented our structure-guided design of RH5top, our latest blood stage-malaria vaccine immunogen, in talk and poster at the Malaria Gordon conference. The culmination of many studies from the lab and collaborators and doing well in pre-clinical testing! More soon.
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Reposted by Dr Ellen Knuepfer
Keith Matthews @keithrmatthews.bsky.social · 16/05/2025
Please consider applying for a post doc in our lab if you have bioinformatics and wet lab skills, and are interested in parasites! elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
elxw.fa.em3.oraclecloud.com
Postdoctoral Research Associate
This project will seek to understand the basis of increased virulence after long term coinfection by a combination of genomic, transcriptomic and laboratory manipulation of the selected parasite lines...
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Reposted by Dr Ellen Knuepfer
knuepferlab.bsky.social @knuepferlab.bsky.social · 06/05/2025
The KnuepferLab is hiring! Our team is looking for a highly motivated, experienced molecular parasitologist to expand our group as a postdoctoral researcher at the RVC. Follow either link below for more information on the project and the job offer: lnkd.in/eprgmaE9 www.jobs.ac.uk/job/DMY962/p...
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Dr Ellen Knuepfer @eknuepfer.bsky.social · 29/04/2025
Hear, hear.
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Reposted by Dr Ellen Knuepfer
Professor John R. Hutchinson @johnrhutchinson.bsky.social · 29/04/2025
Fossils of Mesozoic monotremes are VERY rare so this is a big deal. I'm not aware of other Mesozoic monotreme postcrania. Just jaws/?skull bits and teeth.
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Reposted by Dr Ellen Knuepfer
The Francis Crick Institute @crick.ac.uk · 29/04/2025
Crick researchers have uncovered how the intestinal Cryptosporidium parasite uses a protein to alter its host’s gut environment, enabling the parasite to survive and replicate. www.crick.ac.uk/news/2025-04...
crick.ac.uk
Researchers uncover how intestinal parasite Cryptosporidium alters host cells
Researchers at the Francis Crick Institute have shown that the Cryptosporidium parasite exports a protein into infected intestinal cells, altering the gut environment and enabling the parasite to surv...
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Reposted by Dr Ellen Knuepfer
veupathdb.org @veupathdb.org · 21/04/2025
Keep VEuPathDB open-access to all by subscribing today! veupathdb.org/veupathdb/ap...
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Reposted by Dr Ellen Knuepfer
Eva Frickel @frickellab.bsky.social · 13/04/2025
🔥 Open postdoc position in human inflammation-driven control of infection! 🔥 Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5) Please share!
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Reposted by Dr Ellen Knuepfer
The Royal Society @royalsociety.org · 02/04/2025
“If countries like the US neglect the research base, that would be bad for science, bad for the countries who have thrived on scientific progress, both socially and economically, and bad for the world.” Adrian Smith, President of the Royal Society bit.ly/3XGKixE
docs.google.com
Public Statement on Supporting Science for the Benefit of All Citizens
TO THE AMERICAN PEOPLE We all rely on science. Science gave us the smartphones in our pockets, the navigation systems in our cars, and life-saving medical care. We count on engineers when we drive acr...
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Reposted by Dr Ellen Knuepfer
Alexandra Witze @alexwitze.bsky.social · 27/03/2025
We polled Nature readers to ask if they were thinking of leaving the US for jobs abroad. Three-quarters of them (who said they were US-based scientists) said yes. 🧪 www.nature.com/articles/d41...
nature.com
75% of US scientists who answered Nature poll consider leaving
More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.
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Dr Ellen Knuepfer @eknuepfer.bsky.social · 04/03/2025
How disappointing! Again a large and prestigious institution crumbles when it needed to step up and honour its values.
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Dr Ellen Knuepfer @eknuepfer.bsky.social · 15/02/2025
Happy World Pangolin day m.youtube.com/watch?v=WR0B...
m.youtube.com
World Pangolin Day 2025
On World Pangolin Day 2025, we celebrate the incredible story of hope and freedom as we witness the moment a rescued pangolin returns to the wild. After a long and difficult journey of rehabilitation, this pangolin is finally free to roam its natural habitat once again. The release into the wild is not just the end of a journey—it’s the beginning of a new chapter for this precious creature. It’s a symbol of all the efforts made to protect and preserve species on the brink of extinction. The wild is where this pangolin belongs, and every release like this brings us one step closer to a world where pangolins and other endangered animals can thrive once again. But this moment of freedom is bittersweet—while we’re filled with joy to see the pangolin return home, we know that the fight for its survival continues. Every pangolin released is a reminder of how fragile life is and how much work remains to protect the future of wildlife. Let’s come together to ensure that these magnificent creatures have a safe place to call home. Every small action can make a world of difference.
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Reposted by Dr Ellen Knuepfer
robmoon.bsky.social @robmoon.bsky.social · 07/02/2025
The papers from Jenna Oberstaller and Brendan Elsworth use the piggy-bac transposing system to work out which of P. knowlesi’s 5000 genes are essential for blood stage growth - providing a treasure trove of data for the field to now exploit!
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