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Elizabeth Rideout

@ejrideout.bsky.social
2.1K followers 1.7K following 101 posts

My lab studies sex differences in metabolism and metabolic disease in flies and mice. #sexdifferences #Drosophila #lipid #insulin #betacell

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Reposted by Elizabeth Rideout
Meet Zandawala @zandawala.bsky.social · 29/05/2026
Zandawala lab is looking to recruit a postdoc to work on neuromodulation of feeding in Drosophila and other arthropods at KU Leuven (Leuven, Belgium). Details for the position can be found here: www.kuleuven.be/personeel/jo... Please share!
kuleuven.be
Postdoctoral Researcher in Neuromodulation of Feeding
We are recruiting a postdoctoral scientist to join the recently opened Zandawala Lab at KU Leuven. The position is funded by an Odysseus grant from FWO (Research Foundation – Flanders). For more infor...
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Elizabeth Rideout @ejrideout.bsky.social · 17/05/2026
Gorgeous! Springtime is the best 😊
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Reposted by Elizabeth Rideout
Judith Mank @judithmank.bsky.social · 11/05/2026
Mankees are headed to #CSEE2026! Check out @squarehare.bsky.social's and @joellelafond.bsky.social's talks about Poecilia sex chromosomes, and @vdbijl.bsky.social's talk about evolutionary repeatability of male colour.
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Elizabeth Rideout @ejrideout.bsky.social · 01/05/2026
So many lovely papers in here - check them out! Very grateful to be part of this network 😊
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Elizabeth Rideout @ejrideout.bsky.social · 01/05/2026
Delighted you have settled there so well and are loving it 😊
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Reposted by Elizabeth Rideout
Women's Health Research Institute @womensresearch.bsky.social · 26/04/2026
On March 24 & 25, WHRI leaders highlighted BC’s role in advancing women’s health research at the first-ever National Women’s Health Summit, hosted with @pwhrcanada.bsky.social. A conversation with Danièle Henkel explored federal leadership in women’s health and Bill S-243. bit.ly/4e0IoRj
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Elizabeth Rideout @ejrideout.bsky.social · 23/04/2026
Thanks for having us!!! Hope the students had a great time with their 3MT!
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Elizabeth Rideout @ejrideout.bsky.social · 22/04/2026
Thanks Meet!
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Reposted by Elizabeth Rideout
PLOS Biology @plosbiology.org · 20/04/2026
The #circadian clock & cellular #metabolism are tightly coupled. Yao Cai & @joanna-chiu.bsky.social explore a @plosbiology.org study showing how #glucose metabolism changes during the day in #Drosophila and how it is disrupted in clock & sleep mutants 🧪 Paper: plos.io/3Olm1M1 Primer: plos.io/4sUov2g
Clock-gated morning rush hour of glucose utilization depicted as highway traffic. In the morning (left), clock-controlled food intake at dawn results in high glucose concentration in Drosophila body tissues, analogous to higher number of vehicles on the highway. This increased “traffic flow”, defined by the total number of vehicles passing a given point in a given time, is aided by the opening of the “7AM-11AM only” lanes that are gated by the circadian clock. This is analogous to higher metabolic flux in the morning hours in fly tissues. In other times of the daily cycle (right), both glucose concentration (number of cars) and pathway flux (traffic flow) are low. Vehicle icons were generated by authors using Google’s Nano Banana 2 from the prompts such as “create a top-view of a car icon in white background”, February 16, 2026.
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Reposted by Elizabeth Rideout
fly paper broadcast @fly-broadcast.bsky.social · 20/04/2026
Preconception exposures of female mice to a panel of metabolic disruptors induce sexually dimorphic metabolic perturbations in their offspring #Drosophila
pubmed.ncbi.nlm.nih.gov
Preconception exposures of female mice to a panel of metabolic disruptors induce sexually dimorphic metabolic perturbations in their offspring #Drosophila
PubMed link
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Reposted by Elizabeth Rideout
Meet Zandawala @zandawala.bsky.social · 20/04/2026
Can a single brain cell decide whether to eat or not? 🧠🪰 Turns out... yes. And we found it in the fruit fly. A pair of neurons called SELKs (subesophageal leucokinin neurons) can drive feeding behavior in both directions. They promote it or suppress it. Here's how: 🧵
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Elizabeth Rideout @ejrideout.bsky.social · 21/04/2026
Congratulations Meet!!
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Elizabeth Rideout @ejrideout.bsky.social · 20/04/2026
I need to work harder, I don't even control my office thermostat....😂
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Elizabeth Rideout @ejrideout.bsky.social · 20/04/2026
Thank you so much - excellent work by our teams made this collaboration really fun!
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Elizabeth Rideout @ejrideout.bsky.social · 19/04/2026
Thanks Parthive!!
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Elizabeth Rideout @ejrideout.bsky.social · 19/04/2026
Thank you!
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Elizabeth Rideout @ejrideout.bsky.social · 19/04/2026
Thank you Shefali!
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Elizabeth Rideout @ejrideout.bsky.social · 19/04/2026
😂
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Elizabeth Rideout @ejrideout.bsky.social · 18/04/2026
Congratulations Maria - amazing news 🎉
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Elizabeth Rideout @ejrideout.bsky.social · 18/04/2026
Congratulations to you and your team on the paper 🎉
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Elizabeth Rideout @ejrideout.bsky.social · 18/04/2026
Looking forward to reading this!!
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Elizabeth Rideout @ejrideout.bsky.social · 16/04/2026
Thank you Julia!! Hope you are well 😊
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Elizabeth Rideout @ejrideout.bsky.social · 16/04/2026
Thank you Maria!!! Hope you enjoy 😊
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Elizabeth Rideout @ejrideout.bsky.social · 16/04/2026
Thanks Tony!! There sure is a lot to build on in there, and in the end the fantastic effort by our teams made the paper stronger 😅
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Elizabeth Rideout @ejrideout.bsky.social · 15/04/2026
Thanks Stephen - and congratulations right back at you on the back-to-back papers!!!
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Elizabeth Rideout @ejrideout.bsky.social · 15/04/2026
Thanks Mike, I really appreciate your support. Saw version 2 of your SREBP preprint yesterday, amazing work!
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Elizabeth Rideout @ejrideout.bsky.social · 14/04/2026
Also grateful for the privilege to do this work on the traditional, ancestral, and unceded territory of the Musqueam people at UBC, and for institutional support from @ubccps.bsky.social @ubcmedicine.bsky.social and @crchum.bsky.social @umontreal-en.bsky.social /end
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Elizabeth Rideout @ejrideout.bsky.social · 14/04/2026
Very grateful to everyone who gave their time to provide feedback on the project over the years. And a huge THANK YOU to all the wonderful public resources we exploited to complete this project: Fly Cell Atlas, @bdsc.bsky.social @flybase.bsky.social @vdrc-flies.bsky.social /10
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Elizabeth Rideout @ejrideout.bsky.social · 14/04/2026
Overall, this was a super fun collaboration that answered some questions and opened up many future research directions - we are excited to keep learning more! /9
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Elizabeth Rideout @ejrideout.bsky.social · 14/04/2026
What was remarkable, at least to me, was that across both species the effects of neuronal ATGL loss on energy homeostasis were specific to males. This raises a lot of intriguing questions about sex differences in neuronal lipid metabolism. /8
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Elizabeth Rideout @ejrideout.bsky.social · 14/04/2026
Mechanistically, we show ATGL function supplies fatty acids and phospholipids in these hunger-activated neurons to sustain mitochondrial and endoplasmic reticulum homeostasis. /7
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Elizabeth Rideout @ejrideout.bsky.social · 14/04/2026
In particular, we showed that the neuroanatomical focus of ATGL's effects on energy homeostasis lies in hunger-activated neurons. In flies these are the Adipokinetic hormone-producing cells and in mice they are the AgRP neurons. /6
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Elizabeth Rideout @ejrideout.bsky.social · 14/04/2026
Across flies, worms, and mice we showed that neuronal ATGL loss impairs parameters of energy homeostasis (e.g., fat metabolism in flies and worms, food intake and energy expenditure in mice). This identifies a highly conserved role for neuronal ATGL in regulating nLD and physiology. /5
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Elizabeth Rideout @ejrideout.bsky.social · 14/04/2026
To answer these questions, we identified a gene network regulating nLD in vivo including ATGL. Follow-up studies targeted ATGL as it catalyzes the first step of triglyceride breakdown, and we showed neuronal loss of Drosophila ATGL impairs fat metabolism (PMID 31961851). /4
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Elizabeth Rideout @ejrideout.bsky.social · 14/04/2026
In brief, we show that in both flies and mice neuronal lipid droplets (nLD) are present in vivo under normal physiological conditions. This raised interesting questions about how nLD support neuron function and influence physiology. /3
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Elizabeth Rideout @ejrideout.bsky.social · 14/04/2026
We are incredibly grateful to a suite of collaborators without whom this paper wouldn't have been possible: Drs. Stephanie Fulton, Tao Huan, Matthieu Ruiz, Baptiste Lacoste, Ciaran Murphy-Royal, Martine Tetrault, Marie-Eve Tremblay, J. Alex Parker. /2
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Elizabeth Rideout @ejrideout.bsky.social · 14/04/2026
Beyond delighted to share our amazing collaboration with Thierry Alquier's lab @alquierthierry.bsky.social on a conserved role for neuronal lipid droplets in regulating energy homeostasis in vivo led by Celena Cherian, Romane Manceau, Danie Majeur, and Colin Miller www.nature.com/articles/s42... /1
nature.com
Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis - Nature Metabolism
In vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.
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Reposted by Elizabeth Rideout
FlyBase @flybase.bsky.social · 15/12/2025
We have recently updated FlyCyc biocyc.org/DMEL/organis..., the pathway-genome database representing Drosophila metabolism, to include enzymatic complexes as well as further improvements to enzyme annotations. #FlyCyc is now classed as a ‘Tier 1 Highly Curated Organism Database’.
Screenshot of the FlyCyc page at https://biocyc.org.
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Reposted by Elizabeth Rideout
Mark A. Hanson @hansonmark.bsky.social · 28/11/2025
Now published as version of record at @elife.bsky.social ! Layers of Immunity: Deconstructing the Drosophila effector response. The tools are now deposited in the VDRC (link ⬇️) elifesciences.org/articles/107... shop.vbc.ac.at/vdrc_store/d... #Drosophila #IDsky #SymbioSky #Infection #Immunology
eLife Assessment
This work provides one of the first important attempts to look at Drosophila immune responses against bacterial, viral, and fungal pathogens in a way that combines the roles of four major arms in immunity (Imd signaling, Toll signaling, phagocytosis, and melanization) rather than studying them separately. The findings are compelling and the tools provided can be used as they are, or built upon, in various contexts.

https://doi.org/10.7554/eLife.107030.3.sa0Figure 1 validating the mutations usedFigure 3 summarising the survival results from a 14-genotype 25-pathogen panel.Tracking of mortality and pathogen growth over time, complemented by Figure 5 (not shown) looking at pathogen load upon death.
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Reposted by Elizabeth Rideout
Society for Developmental Biology @socdevbio.bsky.social · 28/11/2025
✨A gut feeling you’ll love this one 🐛 The anterior midgut of a Drosophila melanogaster 🪰larva puts on a confocal glow show! 🟢 Adult midgut progenitors 🔴 Actin 🔵 Nuclei 📸Image by Sapna Krishnakumar #FluorescenceFriday #Microscopy #DevBio
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Reposted by Elizabeth Rideout
Robert Screaton @roblab.bsky.social · 26/11/2025
Islet Biologists in 🇨🇦 🏆 @cirtn.bsky.social
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Reposted by Elizabeth Rideout
eric lai @lucksmith.bsky.social · 29/10/2025
🪰 folks! I spoke to the Transmitter about FlyBase. As noted at flybase.org, bridge $ ran out and many staff were laid off. Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2 tinyurl.com/FlyBase
tinyurl.com
FlyBase secures funding for year, but future still uncertain
The FlyBase team’s fundraising efforts have proven successful in the short term, but restoration of its federal grant remains uncertain.
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Reposted by Elizabeth Rideout
Kristin Connor @kconnor.bsky.social · 10/10/2025
📣Tomorrow is International #DayoftheGirl & 30 years since the Beijing Declaration on advancing equity, development & peace for all women & girls 📈We must scale investment in girls — including through research, health, education & empowerment- -a commitment we make in our lab #GenerationEquality
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Reposted by Elizabeth Rideout
The Interactive Fly @interactivefly.bsky.social · 06/10/2025
Burgmer, S., Meyer Zu Altenschildesche, F., Gyenis, A., Lee, H., Vilchez, D., Giavalisco, P., Fichant, A., Uhlirova, M., Storelli, G. (2025). Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling. Cell Rep, 44(6):115811 www.cell.com/cell-reports...
cell.com
Endosymbiont control through non-canonical immune signaling and gut metabolic remodeling
Burgmer et al. show that the pattern recognition receptors (PRRs) PGRP-LC and PGRP-LE repress key metabolic functions in the Drosophila midgut. These regulations occur independently of canonical immun...
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Elizabeth Rideout @ejrideout.bsky.social · 06/10/2025
Another amazing achievement from the fly community 🤩
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Reposted by Elizabeth Rideout
Nature Cell Biology @natcellbio.nature.com · 04/10/2025
💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth. bit.ly/4gX6njF
bit.ly
Remote control of AMPK via extracellular adenosine controls tissue growth - Nature Cell Biology
Zhang et al. demonstrate that AMPK can be activated by signalling metabolite, adenosine, under non-stress conditions during Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
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Reposted by Elizabeth Rideout
Instituto de Neurociencias CSIC-UMH @neuroalc.bsky.social · 29/09/2025
🪰 More than 750 scientists from 40+ countries gathered in Alicante for the XXVIII European Drosophila Research Conference #EDRC2025. For 4 days, the fruit fly took center stage as a model to study health, aging, and disease👏 @edrc2025.bsky.social @csic.es @dicv.csic.es @umh.es
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Reposted by Elizabeth Rideout
European Drosophila Society @fly-eds.bsky.social · 28/09/2025
Thank you to all #EDRC2025 participants and a big applause to the organizing committee for this great #Drosophila meeting! See you all in Bonn for #EDRC2027
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Reposted by Elizabeth Rideout
Lucas Waltzer @lucaswaltzer.bsky.social · 27/09/2025
#edrc2025 European #drosophila Society meeting announces the 2029 meeting location : see you all in Szeged (and Bonn in 2027 of course)!
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