Scourzic et al. show that germinal centre B cells display an enhanced ability to reprogram to induced pluripotent stem cells compared to mature B cells. This ability indicates their higher plasticity ...

Mouse embryonic stem cells (mESCs), in addition to differentiating into the three germ layers, can reverse typical developmental trajectories, as exemplified by their ability to de-differentiate into ...

Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!

The state’s elimination of vaccine mandates is a courageous first step toward decluttering itself of any excess kids.

Cellular Reprogramming

The National Institutes of Health can’t award grants to outside researchers under a new White House restriction.

The order applies to the entirety of new and, possibly, ongoing research grant dollars that go to universities and academic medical centers.

Rescuing biomedical research is every bit as important as saving Medicaid.

Here, Breves et al. profile the 3D enhancer-promoter connectomes of patient-derived glioblastoma stem cells (GSCs), identify hyperconnected 3D regulatory “hubs” relevant for GBM biology, examine the i...

Applications are invited for a 3-year post-doctoral research position at the MRC London Institute of Medical Sciences (LMS) at Imperial College London (http://lms.mrc.ac.uk/).

Pluripotent stem cells are susceptible to acquiring detrimental epigenetic abnormalities, posing a hurdle to their safe use in biomedical applications. Using pluripotent cells with defined genetic bac...

National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

The National Institutes of Health is terminating 232 grants for scientific research at Columbia University Irving Medical Center, according to an email an administrator sent to faculty.

Prior studies showed that structural loops collapse upon acute cohesin depletion, while regulatory enhancer-promoter (E-P) loops largely persist, consistent with minimal transcriptional changes. Howev...

MSK research provides a clearer understanding of glioblastoma heterogeneity to aid development of new therapies; sheds light on mechanisms of cellular plasticity; presents a new imaging technique that...