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Edmund Miller

@edmundmiller.dev
1.4K followers 2K following 70 posts

PhD Candidate @ UT Dallas in the Functional Genomics Lab working on Nascent RNA identification @nf-co.re Bioinformatics Engineer @seqera.io link.edmundmiller.dev

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Reposted by Edmund Miller
Seqera @seqera.io · 24/10/2025
🚀 Introducing the @nextflow.io Plugins Registry: a centralized repository for discovering, sharing, and managing #Nextflow plugins. We've streamlined the entire plugin lifecycle for the bioinformatics community. 🧑‍💻Explore today: hubs.la/Q03P_Q8t0
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Reposted by Edmund Miller
Seqera @seqera.io · 20/10/2025
Attending SBI2 2025 in Boston next week? Join Ken Brewer (Scientific Solutions Lead) for the @nextflow.io for bioimaging workshop!🔬Sign up for the workshop when you register for the conference: hubs.la/Q03Ph_d10
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Reposted by Edmund Miller
Yo Akiyama @yoakiyama.bsky.social · 05/08/2025
Excited to share work with Zhidian Zhang, @milot.bsky.social, @martinsteinegger.bsky.social, and @sokrypton.org biorxiv.org/content/10.1... TLDR: We introduce MSA Pairformer, a 111M parameter protein language model that challenges the scaling paradigm in self-supervised protein language modeling🧵
biorxiv.org
Scaling down protein language modeling with MSA Pairformer
Recent efforts in protein language modeling have focused on scaling single-sequence models and their training data, requiring vast compute resources that limit accessibility. Although models that use ...
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Reposted by Edmund Miller
Javier Santoyo @jsantoyo.bsky.social · 16/08/2025
GFFx: A Rust-based suite of utilities for ultra-fast genomic feature extraction. #Genomics #Rust #GenomeAnnotation #GFF #GenomicFeatures @biorxiv-bioinfo.bsky.social 🧬 🖥️ www.biorxiv.org/content/10.1...
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Reposted by Edmund Miller
plantgenomics.bsky.social @plantgenomics.bsky.social · 17/08/2025
nf-core/proteinfamilies: A scalable pipeline for the generation of protein families doi.org/10.1101/2025... Automatic identification and annotation of MYB gene family members in plants doi.org/10.1101/2021...
doi.org
nf-core/proteinfamilies: A scalable pipeline for the generation of protein families
The growth of metagenomics-derived amino acid sequence data has transformed our understanding of protein function, microbial diversity and evolutionary relationships. However, the vast majority of the...
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Reposted by Edmund Miller
Pooja Kathail @poojakathail.bsky.social · 20/11/2024
Super excited to share our review on genomic deep learning models for non-coding variant effect prediction, with Ayesha Bajwa and Nilah Ioannidis. We’d like this review to be a useful resource, and welcome any feedback, comments, or questions! 1/4 arxiv.org/abs/2411.11158
arxiv.org
Leveraging genomic deep learning models for non-coding variant effect prediction
The majority of genetic variants identified in genome-wide association studies of complex traits are non-coding, and characterizing their function remains an important challenge in human genetics. Gen...
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Reposted by Edmund Miller
Seqera @seqera.io · 10/07/2025
💡 Run custom applications on the same infrastructure as your @nextflow.io pipelines with Studios 🧵Read the blog to find out how! hubs.la/Q03wC-3p0
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Reposted by Edmund Miller
Seqera @seqera.io · 24/06/2025
Don't miss our webinar with @bigomics.bsky.social tomorrow! Join us to discover how the integration of Omics Playground into Seqera Studios is supporting faster, scalable end-to-end omics analysis. 💻 Register now: hubs.la/Q03tjp-50
hubs.la
Powering Interactive Omics Analysis with BigOmics Analytics and Studios | Seqera
Join us for an insightful webinar with BigOmics Analytics as we showcase the integration of Omics Playground into Studios as a powerful new way to interactively explore RNA-Seq and proteomics results ...
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Edmund Miller @edmundmiller.dev · 12/06/2025
We got some amazing results from combining @seqera.io Fusion and NVIDIA Healthcare Parabricks! Can’t wait to start implementing all of the benefits of gpu workflows across all of the @nf-co.re pipelines!
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Reposted by Edmund Miller
Seqera @seqera.io · 12/06/2025
🚀 We’ve teamed up with #NVIDIA to help bioinformatics teams scale faster, analyze more efficiently, and simplify cloud operations 🧵 📖 Read now: hubs.la/Q03rQZx-0
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Edmund Miller @edmundmiller.dev · 11/06/2025
What is This, a Crossover Episode? So excited to see the Modern Data Stack and Modern Biotech Stack collide!
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Edmund Miller @edmundmiller.dev · 23/05/2025
Maybe it was just the post-pandemic travel or finally meeting the @nextflow.io community in person, but @paoloditommaso.bsky.social blew my mind with Wave that day. 😂 youtu.be/PTbiCVq0-sE?...
youtu.be
Nextflow Summit 2022 - Paolo di Tommaso
YouTube video by Nextflow
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Reposted by Edmund Miller
Seqera @seqera.io · 15/05/2025
We’ve just dropped some powerful new @nextflow.io features as part of the 25.04 release, all designed to enhance clarity, control, and collaboration in workflow development. 🎉 💡Learn more: hubs.la/Q03mQ2_10
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Reposted by Edmund Miller
Seqera @seqera.io · 16/05/2025
Supporting Community at the Core of Innovation 🌍🙌 We were honored to provide space at the #NextflowSummit Boston for the incredible Boston Women in Bioinformatics group to gather, connect, and celebrate a major milestone: becoming a 501(c)(3) nonprofit! 🎉
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Seqera @seqera.io · 15/05/2025
🚀 Introducing Seqera Compute: Managed, Optimized Compute for Scalable Bioinformatics 📕Read the blog post: hubs.la/Q03mKwMb0 🔍Discover Seqera Compute: hubs.la/Q03mKxyB0
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Reposted by Edmund Miller
Seqera @seqera.io · 06/05/2025
To continue advancing the vision that scientific innovation runs on software, we are thrilled to announce that Seqera has closed it’s Series B funding, led by Addition, with participation from Speedinvest, Talis, Amino Collective, BoxOne, and SNR! Learn more: hubs.la/Q03lcmf20
hubs.la
Scaling the Future of Scientific Software: Seqera Raises $26M Series B
Today, we're ecstatic to announce that Seqera has raised $26 million in Series B funding, led by Addition with participation from Speedinvest, Talis, Amino Collective, BoxOne, and SNR. This milestone ...
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Reposted by Edmund Miller
Prefix.dev - the Pixi company @prefix.dev · 26/03/2025
Dive into Pixi Packages! 🛠️ Build packages from source 📦 Cross-platform and cross-language ✨ Build backends for powerful standards! Currently released as a preview feature, with improvements dropping daily!
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Edmund Miller @edmundmiller.dev · 27/03/2025
Pixi has shebang support like uv now! 😍 ``` #!/usr/bin/env -S pixi exec --spec bat -- bash -e ``` pixi.sh/dev/advanced...
pixi.sh
Shebang - Pixi by prefix.dev
None
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Edmund Miller @edmundmiller.dev · 26/03/2025
Severance is just docker for brains🐳🧠
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Reposted by Edmund Miller
nf-core @nf-co.re · 20/03/2025
New blog post! Spring cleaning 2025 nf-co.re/blog/2025/springcleaning
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Reposted by Edmund Miller
nf-core @nf-co.re · 21/03/2025
Next week is the March 2025 @nf-co.re #hackathon! 🎉 With 44 local sites across 27 countries, this event is truly global 🌏🌏🌎 We have 992 people registered - so close to 1000! Register here: nf-co.re/events/2025/... 🎟 ✍️ If you still need convincing, here's a little video to whet your appetite 👩🏻‍💻
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Reposted by Edmund Miller
Davis Vaughan @davisvaughan.bsky.social · 21/02/2025
@lionelhenry.bsky.social and I are so excited to finally announce Air - an extremely fast R code formatter! 🎉 With Air, you'll never need to worry about styling your #rstats code ever again. All you need to do is save, and Air takes care of the rest. www.tidyverse.org/blog/2025/02...
tidyverse.org
Air, an extremely fast R formatter
We are thrilled to announce Air, a new R formatter.
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Reposted by Edmund Miller
Seqera @seqera.io · 12/02/2025
🎤Call for Speakers! The @nextflow.io Summit returns to Boston this May! We’re looking for speakers to showcase groundbreaking research, innovative solutions, and real-world success stories. 👉 Submit your abstract by March 14 to be part of the lineup: hubs.la/Q036sG6T0
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Edmund Miller @edmundmiller.dev · 09/02/2025
Been looking forward to this talk since @alexpeltzer.bsky.social told me about DSO in October!
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Edmund Miller @edmundmiller.dev · 29/01/2025
join.slack.com/share/enQtOD...
join.slack.com
Slack
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Edmund Miller @edmundmiller.dev · 29/01/2025
Come hang out in the #arm64 Slack channel! join.slack.com/share/enQtOD...
join.slack.com
Slack
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Reposted by Edmund Miller
Seqera @seqera.io · 28/01/2025
Attending #SLAS2025? Don't miss our exclusive Exhibitor Tutorial at 2:00 PM today in Room 24C! In this talk, we will discuss how @nextflow.io and Seqera are simplifying the analysis of large-scale sequencing and cell imaging data! 🔗 Can't attend? Get the recording instead: hubs.la/Q034lfYZ0
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Reposted by Edmund Miller
Stephen Turner @stephenturner.us · 27/01/2025
Genetic coupling of enhancer activity and connectivity in gene expression control www.nature.com/articles/s41467-025-… 🧬🖥️🧪 ...beautiful plots made with #Rstats plotgardner phanstiellab.github.io/plotgardener
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Edmund Miller @edmundmiller.dev · 28/01/2025
Is there an LSP? 👀
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Edmund Miller @edmundmiller.dev · 26/01/2025
Stop by and say hello if you’re there!
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Reposted by Edmund Miller
Seqera @seqera.io · 14/01/2025
There's been a rapid growth in Australian researchers utilizing @nextflow.io for developing workflows, aswell as already implemented workflows from @nf-co.re and other open-source resources. In response, @ausbiocommons.bsky.social established the Australian Nextflow Seqera Service 🧵
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Reposted by Edmund Miller
Stephen Turner @stephenturner.us · 24/01/2025
Bluesky’s science takeover: 70% of Nature poll respondents use platform www.nature.com/articles/d41586-025-…
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Reposted by Edmund Miller
Love Dalén @lovedalen.bsky.social · 07/01/2025
At Stockholm University, we are now starting a 2-year Master’s programme in Evolutionary Genomics! Topics include population genetics, phylogenetics, molecular & genome evolution, DNA sequencing, bioinformatics, and palaeogenetics. Please spread the word! www.su.se/english/sear...
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Edmund Miller @edmundmiller.dev · 20/01/2025
edmundmiller.dev/posts/altair...
edmundmiller.dev
altair-upset: The Evolution of UpSet plots in Altair
How I turned a Jupyter notebook into a full-fledged Python package for UpSet plots
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Edmund Miller @edmundmiller.dev · 20/01/2025
Went down a rabbit hole this weekend and wrote my first Python package that I published end to end! It's just a package of a wonderful Jupyter notebook for making UpSet plots in Altair! github.com/hms-dbmi/ups...
Upset plot of Shared Mutations of COVID Variants
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Reposted by Edmund Miller
Albert Vilella, PhD. @albertvilella.bsky.social · 13/01/2025
This meme picture made me laugh... #NextFlow #CWL #SnakeMake #Galaxy
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Edmund Miller @edmundmiller.dev · 12/01/2025
No that's `uvx` which is the `pipx` equivalent. I'm gonna guess your point stands and `pipx git+https://...` works the same way though. But I don't know if pipx let's you specificy the dependancies if the project doesn't declare them. `uvx --with rich-click git+https://` for example.
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Reposted by Edmund Miller
Anshul Kundaje @anshulkundaje.bsky.social · 08/01/2025
Congrats to Johannes Linder, David Kelley et al. on the journal publication of Borzoi - a long context sequence models of RNA-seq coverage profiles with many nice applications for transcriptional & post-transcriptional regulation & variant effect prediction. www.nature.com/articles/s41... 1/
nature.com
Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation - Nature Genetics
Borzoi adapts the Enformer sequence-to-expression model to directly predict RNA-seq coverage, enabling the in-silico analysis of variant effects across multiple layers of gene regulation.
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Reposted by Edmund Miller
Anshul Kundaje @anshulkundaje.bsky.social · 07/01/2025
Very excited to announce that the single cell/nuc. RNA/ATAC/multi-ome resource from ENCODE4 is now officially public. This includes raw data, processed data, annotations and pseudobulk products. Covers many human & mouse tissues. 1/ www.encodeproject.org/single-cell/...
encodeproject.org
Single cell – ENCODEHomo sapiens clickable body map
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Reposted by Edmund Miller
David Mas-Ponte @david.masponte.com · 05/01/2025
another example is scale bio's ScaleMethyl, they released a public @nextflow.io pipeline alongside their product to process the raw reads. github.com/ScaleBio/Sca...
github.com
GitHub - ScaleBio/ScaleMethyl
Contribute to ScaleBio/ScaleMethyl development by creating an account on GitHub.
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Reposted by Edmund Miller
BioMassSpec @realbiomassspec.bsky.social · 05/01/2025
Nextflow4MS-DIAL: A Reproducible Nextflow-Based Workflow for Liquid Chromatography–Mass Spectrometry Metabolomics Data Processing #JASMS pubs.acs.org/doi/10.1021/...
pubs.acs.org
Nextflow4MS-DIAL: A Reproducible Nextflow-Based Workflow for Liquid Chromatography–Mass Spectrometry Metabolomics Data Processing
Reproducibility in untargeted metabolomics data processing remains a significant challenge due to software limitations and the complex series of steps required. To address these issues, we developed N...
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Edmund Miller @edmundmiller.dev · 05/01/2025
The speed of uv isn't what drew me in. It's the small developer experience improvements over other Python package managers that have me hooked and excited about Python for the first time.
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Edmund Miller @edmundmiller.dev · 05/01/2025
Another little uv trick I learned yesterday: ``` uvx --from git+https://github.com/httpie/cli httpie ``` You can just run #Python scripts from any git repo, no need for them to publish on PyPI.
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Edmund Miller @edmundmiller.dev · 05/01/2025
The feature you didn't know you've always wanted. Suddenly that one-off python script has a chance at being self-contained and reproducible. It get's even better when you extend the concept and use it with @marimo.io to run notebooks in a sandbox docs.marimo.io/guides/edito...
docs.marimo.io
Package Management - marimo
The next generation of Python notebooks
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Edmund Miller @edmundmiller.dev · 05/01/2025
What's a uv run shebang you ask? simonwillison.net/2024/Aug/21/... You can declare your Python depedancies in a comment block, chmod the script, and uv will install the dependancies when you run the script(or in a few months)
simonwillison.net
#!/usr/bin/env -S uv run
This is a really neat pattern. Start your Python script like this: #!/usr/bin/env -S uv run # /// script # requires-python = ">=3.12" # dependencies = [ # "flask==3.*", # …
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Edmund Miller @edmundmiller.dev · 05/01/2025
Made a snippet for a uv run shebang because I got tired of hunting it down everytime I wanted to add it to a new script: github.com/edmundmiller...
github.com
.doom.d/snippets/python-mode/uvbang at 3f53f48071035fdc498a5cf36fff31e51b537367 · edmundmiller/.doom.d
My private module for Doom Emacs. Contribute to edmundmiller/.doom.d development by creating an account on GitHub.
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Edmund Miller @edmundmiller.dev · 31/12/2024
I wrote the majority of it with github.com/Aider-AI/aider. I probably never would've found the time to read through the docs myself and make sense of the API, because it wasn't enough of a priority to me in the past to justify the time investment.
github.com
GitHub - Aider-AI/aider: aider is AI pair programming in your terminal
aider is AI pair programming in your terminal. Contribute to Aider-AI/aider development by creating an account on GitHub.
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Edmund Miller @edmundmiller.dev · 31/12/2024
github.com/edmundmiller... It's pretty easy to get going: 1. Save the code as `gff.py` in your VisiData plugins directory (~/.visidata/plugins/) 2. Launch VisiData with any GFF file: vd your_file.gff
github.com
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Edmund Miller @edmundmiller.dev · 31/12/2024
Something that had been on my wishlist for a long time was a #Visidata plugin for common tabular #bioinformatics formats. I got by with just telling Visidata they were TSVs. Finally got around to writing a GFF plugin asciinema.org/a/Nt0AlgvxsX... 🧬🖥️
asciinema.org
Visidata GFF Pplugin
Recorded by emiller
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Reposted by Edmund Miller
Xe @xeiaso.net · 26/12/2024
www.nature.com/articles/s43... we made The Matrix for worms
nature.com
An integrative data-driven model simulating C. elegans brain, body and environment interactions - Nature Computational Science
BAAIWorm is an integrative data-driven model of C. elegans that simulates interactions between the brain, body and environment. The biophysically detailed neuronal model is capable of replicating the ...
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