Macroalgae, the dominant primary producers of Earth’s most productive coastal vegetated ecosystems and a vital component driving ocean carbon sequestration, produce ∼5 to 80% of their net primary prod...

Session List Please see the session formats page for details on possible presentation formats. Jump to: Education and Policy Sessions | Spotlight Session | Amplifying Voices | Contributed Sessions Sci...

The idea of ‘biological agency’ — that life devises its own goals and behaves accordingly — complicates our understanding of what it means to be alive. But does it serve a scientific purpose?

4 scientists explain why the Reflecting Pool may be green instead of blue on July 4.

Establish David Attenborough Day on 8th May

Clardy, J. & Walsh, C. Lessons from natural molecules. Nature 432, 829–837 (2004). Xu, T. et al. NPBS Atlas: a comprehensive data resource for exploring the biological sources of natural products. J. Cheminform. 17, 172 (2025). Newman, D. J. & Cragg, G. M. Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. J. Nat. Prod. 83, 770–803 (2020). Koehn, F. E. & Carter, G. T. The evolving role of natural products in drug discovery. Nat. Rev. Drug Discov. 4, 206–220 (2005). Vanni, C. et al. Unifying the known and unknown microbial coding sequence space. eLife 11, e67667 (2022). Wirbel, J., Bhatt, A. S. & Probst, A. J. The journey to understand previously unknown microbial genes. Nature 626, 267–269 (2024). Scherlach, K. & Hertweck, C. Mining and unearthing hidden biosynthetic potential. Nat. Commun. 12, 3864 (2021). Medema, M. H. et al. antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences. Nucleic Acids Res. 39, W339–W346 (2011). Skinnider, M. A. et al. Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM). Nucleic Acids Res. 43, 9645–9662 (2015). Hannigan, G. D. et al. A deep learning...

Biotic interactions modulate protein abundance, reducing functional redundancy and increasing productivity in complex bacterial communities.

This study introduces KIMMDY, a biomolecular reaction emulator that models complex biochemical reactions in dynamic atomistically resolved systems, from protein radical chemistry to DNA photoreactions.

A nature-inspired ion trap enabling massively parallel mass spectrometry.

Molecular phylogeny is a well-established method for inferring evolutionary relationships from DNA and RNA sequences. Here, we extend this concept beyond genetic information by applying phylogeny-like analysis to proteomic and metabolomic mass spectrometry data, capturing relationships based on the realized molecular phenotype. The resulting phenotype-derived trees can be directly compared with conventional genetic-based trees to identify where molecular phenotypes reflect evolutionary history and where they diverge due to functional adaptation, regulation, or environmental influence. To enable this analysis, we introduce TreeMS2, a computational tool that constructs similarity matrices by directly comparing tandem mass spectrometry (MS/MS) spectra between samples. By bypassing spectrum annotation, TreeMS2 enables rapid, unbiased comparisons. Across diverse datasets, TreeMS2 reconstructs biologically meaningful relationships. In proteomics, phenotype-derived trees recapitulate established taxonomy, with deviations pinpointing sample handling errors. In single-cell proteomics our method distinguishes cell types despite sparse and noisy measurements and in metabolomics it resolves major biochemical divisions and fine-scale compositional structure. Together, these results establish TreeMS2 as a scalable, annotation-independent framework for deriving molecular relationships from raw MS/MS data.

MicrobeAtlas (www.microbeatlas.org) is an integrated, reference-based resource for truly planet-wide microbiomics, analyzing hundreds of thousands of microbial lineages across diverse environments, co...

This study integrated HS-SPME-GC–MS flavoromics, LC–MS metabolomics, and electronic tongue analysis to systematically dissect the metabolic and flavor…

A bottleneck in high-throughput chemical synthesis is analyzing reaction products. This protocol describes a direct mass spectrometry approach where the loss of a characteristic neutral fragment from ...

Scientific Data - Depth-resolved carbon dioxide and methane concentrations in 522 lakes, ponds, and reservoirs worldwide

The bioaccumulation of 80 pharmaceutically active compounds (PhACs) was examined in larvae, pupae, and (sub)adults of three groups of aquatic insects (caddisflies Oligotricha striata and Limnephilus s...

Citizen science data are increasingly used in biodiversity monitoring. This study applies a digital twin approach to biodiversity monitoring using a large citizen science dataset on birds from Finland...

In temperate regions experiencing rapid ocean warming, kelp forests are being replaced by chemically rich turf algae. However, the extent to which these turf algae alter the surrounding chemical envir...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Freshwater ecosystems – comprising rivers, lakes, wetlands, and groundwater systems – play a critical role in sustaining biodiversity, regulating biogeochemical

When studying a complex system, it is often useful to think of the system as a network of interacting units. One can then ask if some properties of...

With so little money to go round, the costs of competing for grants can exceed what the grants are worth. When that happens, nobody wins.

MSnLib is a large-scale, open MSn spectral library featuring >2.3 million MSn and >357,000 MS2 spectra for 30,008 unique small molecules.