Sign in

Darin Takemoto

@dtake01.bsky.social
18 followers 24 following 184 posts

Weeder of woods. Interests: statistics, bioinformatics, music, games.

PostsRepliesMedia
Darin Takemoto @dtake01.bsky.social · 28/09/2026
Despite the claims of RFK Jr. there still is no autism epidemic, just improved detection. Again. medicalxpress.com/news/2026-09...
medicalxpress.com
Study uncovers no evidence of autism epidemic despite claims
Many people, including U.S. Health and Human Services Secretary Robert F. Kennedy Jr., say autism rates have reached epidemic proportions. But while the prevalence of autism spectrum disorder (ASD) ha...
000
Darin Takemoto @dtake01.bsky.social · 18/09/2026
Antisense-RNA therapy results in improvements in an ALS patient caused by a rare mutation in the CHCHD10 gene. Eight other patients with mutations in the same gene have been given the therapy. www.nature.com/articles/d41...
nature.com
First for RNA therapy: man with rare motor-neuron disease improves after treatment
Gene-targeting treatments could be used to treat other people with rare forms of amyotrophic lateral sclerosis (ALS).
000
Darin Takemoto @dtake01.bsky.social · 17/09/2026
As we should endeavor to understand the full breadth of human genomic variation and not just European variation, indigenous collaborations will become more important. doi.org/rppn
doi.org
Ten simple rules for elevating Indigenous partnerships in research
000
Darin Takemoto @dtake01.bsky.social · 17/09/2026
Another day, another report detailing US war crimes. www.npr.org/2026/09/17/n...
npr.org
U.N.-backed experts cite possible U.S. war crimes in Iran, including a school attack
Human rights experts commissioned by the U.N. say they have found "reasonable grounds" to believe the U.S. committed war crimes in Iran, including a strike on a school in the southern city of Minab.
000
Darin Takemoto @dtake01.bsky.social · 16/09/2026
Spatial transcriptomics can be really powerful, but the data are quite noisy and it is really expensive, so only use it if you need it for the problem at hand. doi.org/rpmz
doi.org
Ten quick tips for spatial transcriptomics analysis
Author summary Spatial transcriptomics (ST) lets researchers measure gene expression while preserving the tissue location of each measurement. Where a cell sits, and which cells surround it, shape how...
010
Darin Takemoto @dtake01.bsky.social · 16/09/2026
Now even Ed Sheeran is saying it was the promoter's decision www.today.com/video/ed-she...
today.com
Ed Sheeran’s Opening Acts Drop out in Solidarity With Macklemore
Fallout is growing over rapper Macklemore’s removal from Ed Sheeran’s tour with now every one of Sheeran’s music openers and his onstage band announcing that they would no longer take part in the tour...
000
Reposted by Darin Takemoto
Christopher Webb @cwebbonline.com · 15/02/2025
The new Macklemore video everyone’s talking about. You might think it’s about Palestine, but it’s bigger than that. It’s about social media controlling what we see, hear, and think. It’s a call to action. Whew… “fucked up.” youtu.be/sn9EKC9nqU4?...
youtu.be
MACKLEMORE - fucked up (official video)
YouTube video by Macklemore
20630941179
Darin Takemoto @dtake01.bsky.social · 08/09/2026
Macklemore is being criticized for standing up for people and against genocide and imperialism. What a world. www.aljazeera.com/video/newsfe...
aljazeera.com
Macklemore defends ‘Free Palestine’ call after Ed Sheeran concert backlash
Macklemore is facing backlash from pro-Israel groups after saying ‘Free Palestine’ while opening for Ed Sheeran.
010
Reposted by Darin Takemoto
Molly White @molly.wiki · 05/09/2026
A Wikipedia editor put it well: "You almost want to pat them on the head and say 'Yes, of course it will' in the same way you'd tell a small child that Santa Claus will be delivering their presents."
Other platforms will soon follow, a senior administration official told POLITICO on Tuesday. “We got Lake America changed on Google Maps, and many other maps are changing in a couple days. And Wikipedia is going to change as well,” said the official, who was granted anonymity to speak frankly.
522840439
Reposted by Darin Takemoto
4fuxake @blueheartedly1.bsky.social · 29/08/2026
Every bit of this 👇
19688185
Reposted by Darin Takemoto
4fuxake @blueheartedly1.bsky.social · 28/08/2026
This is part of my vocabulary now 😂
1010420
Reposted by Darin Takemoto
4fuxake @blueheartedly1.bsky.social · 28/08/2026
Every bit of this 👇
291141328
Reposted by Darin Takemoto
Eric Topol @erictopol.bsky.social · 16/08/2026
I'm keen on AI having a transformational impact on human health. But these cure projections are wildly off-base and impossible.
1215024
Darin Takemoto @dtake01.bsky.social · 16/08/2026
Describe your musical taste in three artists, no genres: Bobbi Humphrey Cowboy Junkies La Santa Cecilia
000
Darin Takemoto @dtake01.bsky.social · 16/08/2026
The "pro-lifers" believe in the sanctity of life... until the moment of birth. After that, health care as a right is a communist plot.
040
Reposted by Darin Takemoto
Robert Reich @rbreich.bsky.social · 16/08/2026
The cyclospora outbreak has reached 13,895 cases across 47 states. The FDA has recalled 1.6 million eggs due to salmonella contamination. Screwworm cases continue to rise. And we’ve just surpassed 2,500 measles cases — breaking 2025’s record. “Make America Healthy Again.”
860210307938
Reposted by Darin Takemoto
Saganism @sagan.bsky.social · 14/08/2026
41 years ago, Carl Sagan gave a clear and elegant explanation of the science behind global warming.
393142865760
Darin Takemoto @dtake01.bsky.social · 13/08/2026
Literally every MMORPG. Every one I've tried quickly gets to a point where I. just. can't.
000
Reposted by Darin Takemoto
originaldvd.bsky.social @originaldvd.bsky.social · 09/08/2026
Lake Meade is running out of water. This is outrageous. We are in deep trouble
37842381511
Reposted by Darin Takemoto
Aaron Rupar @atrupar.com · 09/08/2026
El-Sayed: "It means holding people like RFK Jr accountable for the DOGE-ing of our public health, for which we now need to be dodging lettuce across the state of Michigan for fear of getting explosive diarrhea, which nobody ever thought you be a consequence of electing Donald Trump, but here we are"
984404963
Reposted by Darin Takemoto
Massimo (mirror) @rainmaker1973-m.bsky.social · 09/08/2026
Animaris Rex is an 18-metre-long walking 'beach animal' propelled by the wind, created by Theo Jansen as a fusion of art and engineering. Original post
24373101658
Reposted by Darin Takemoto
John Travis @john-travis.bsky.social · 04/08/2026
16 months after a young girl died in a gene-editing trial, the study's entry in clinicaltrial. gov has finally been updated to acknowledge the death. The move comes after @science.org and @retractionwatch.com revealed the fatality 1/ science.org/content/arti...
clinicaltrials.gov
ClinicalTrials.gov
26023
Reposted by Darin Takemoto
Randall Munroe @xkcd.com · 06/08/2026
I really recommend the 2022 documentary “It’s Quieter in the Twilight,” which profiles the scientists working in relative obscurity to keep the Voyager spacecraft operating—many of them past retirement age, but unwilling to quit until the Voyagers do. It was very sweet and thought-provoking.
383683477
Reposted by Darin Takemoto
Al Jazeera English @aljazeera.com · 31/07/2026
The US State Department acknowledged 'an unfortunate error' after the highly inaccurate African map caused a stir.
aljazeera.com
US government mislabels countries on map of Africa at global conference
The US State Department acknowledged 'an unfortunate error' after the highly inaccurate African map caused a stir.
139627
Reposted by Darin Takemoto
Ankit Panda @nktpnd.bsky.social · 30/07/2026
"In an extraordinary development all 55 Uefa members resolved not to participate in future World Cups or other Fifa-run events, saying in a statement that they “unanimously and unequivocally reject” the proposals" www.theguardian.com/football/202...
theguardian.com
Uefa agrees to boycott Fifa competitions if World Cup sell-off plans proceed
Uefa nations have agreed to boycott all Fifa tournaments if the global governing body continues with its plan to sell off stakes in the World Cup
1732780
Darin Takemoto @dtake01.bsky.social · 28/07/2026
Just wow. Infantino's FIFA is the most corrupt organization associated with sports, and that's saying something. www.nytimes.com/athletic/747...
nytimes.com
FIFA plans to sell a stake in the World Cup: How much for and why is Gianni Infantino doing it?
The proposal has been widely criticized, with European soccer's governing body UEFA saying it "crosses a line."
000
Darin Takemoto @dtake01.bsky.social · 24/07/2026
Oops, my bad! Looks like with this peptides guidance MAHA might have fallen below the Mendoza line: www.npr.org/2026/07/23/n...
npr.org
FDA panel backs easier access to peptides
Advisers to the Food and Drug Administration voted in favor of easing regulation of popular peptides. The recommendations could pave the way for specialized pharmacies to produce them in the U.S.
000
Reposted by Darin Takemoto
Science X / Phys.org @sciencex.bsky.social · 23/07/2026
A vessel-based clotting switch reduced arterial clots and vascular blockages in mice without increasing bleeding risk. In 74 patients, higher S1P levels also tracked with lower clotting activity. doi.org/hccfsr
medicalxpress.com
Natural clotting 'switch' may one day reduce reliance on blood thinners to prevent heart attacks and strokes
Cardiovascular conditions such as strokes or heart attacks are among the most common causes of death in Germany. Today, treatment and prevention are primarily based on so-called platelet aggregation inhibitors and anticoagulants—types of medication commonly referred to as blood thinners.
021
Darin Takemoto @dtake01.bsky.social · 23/07/2026
The death of a girl in an n-of-1 Chinese base-editing trial last year is disclosed for the first time. The family paid $860,000 for the trial, and were not told of serious side effects found in primate studies with the base editor. doi.org/rgzs
doi.org
Exclusive: Death of girl in Chinese gene-editing trial was never made public
Parents want accountability after study went disastrously wrong, Science and Retraction Watch investigation reveals
000
Darin Takemoto @dtake01.bsky.social · 23/07/2026
Some useful tips if you want to use AI to make a graphical abstract for a journal article. Useful for those (like me) who are artistically-challenged. www.nature.com/articles/d41...
nature.com
How to use AI to make a graphical abstract in minutes
Artificial intelligence is a democratizing force for those without graphic-design experience, as long as it is used conscientiously.
000
Darin Takemoto @dtake01.bsky.social · 23/07/2026
Are MAHA guidances backed by good science? TL;DR one of the five guidances have reasonable scientific basis. Not great when government health guidances bat at the Mendoza line. www.nature.com/articles/d41...
nature.com
How does Make America Healthy Again hold up against scientific scrutiny?
Researchers share their views on the US health policy spanning topics from vaccines to nutrition.
110
Darin Takemoto @dtake01.bsky.social · 23/07/2026
I low-key wish this was actually a thing. xkcd.com/3275/
xkcd.com
Calibration Nobel
000
Darin Takemoto @dtake01.bsky.social · 18/07/2026
Five authors, including Harvard geneticist George Church, pulled their names from a recent commentary paper in Nature Methods, potentially due to a “potential U.S. government restriction” on collaborations with three blacklisted BGI units. No U.S. authors are in the final author list. doi.org/rf57
doi.org
Did U.S. scrutiny of foreign research drive prominent geneticist to decline authorship?
George Church moved to paper’s acknowledgements section, triggering exodus
010
Reposted by Darin Takemoto
Eric Topol @erictopol.bsky.social · 16/07/2026
This is big. The first vaccine tested to PREVENT pancreatic cancer in high-risk individuals aacrjournals.org/cancerdiscov...
aacrjournals.org
First-in-human testing of a mutant KRAS vaccine for pancreatic cancer interception in high-risk cohorts
Abstract. Pancreatic ductal adenocarcinoma (PDAC) arises from precursor lesions over a decade-plus, offering a window for interception in high-risk individuals, but current surveillance detects a mino...
7837131121
Darin Takemoto @dtake01.bsky.social · 16/07/2026
User-focused tips on scientific software evaluation. The "Ten tips" series is generally useful, but this is particularly good. doi.org/rfxp
doi.org
Ten quick tips to SNIFF out sustainable and secure scientific software
Modern computational biology depends heavily on open-source software tools, analysis pipelines, and containerized workflows developed and shared by the research community. While there is extensive gui...
020
Darin Takemoto @dtake01.bsky.social · 16/07/2026
Using germline genetic data and longitudinal electronic health records to find genetic signatures that are associated with pathogenic trajectories, which can span multiple diseases. doi.org/rfxn
doi.org
A Bayesian framework for longitudinal EHR and genetic discovery - Nature
A Bayesian generative framework that integrates longitudinal electronic health records with genetic data to identify latent disease signatures is presented.
000
Darin Takemoto @dtake01.bsky.social · 15/07/2026
An encyclopedia of human enhancer-gene regulatory interactions based on a predictive model trained on QTLs from GWAS and CRISPR perturbation experiments. doi.org/rfxk
doi.org
An encyclopedia of human enhancer–gene regulatory interactions - Nature
An encyclopedia of more than 92 million enhancer–gene regulatory interactions created as part of the ENCODE4 project provides a valuable resource for future studies of gene regulation and human genetics.
010
Darin Takemoto @dtake01.bsky.social · 12/07/2026
A low-cost genome sequencing method combining 1-4x genome coverage with 30x exome coverage in a single sequencing run reduces sequencing costs by 75% and allows for accurate detection of disease-causing variants and structural variations. phys.org/news/2026-07... doi.org/hb96wp
phys.org
Low-cost genome sequencing approach is powering genetics research on mental illness and many other studies
For researchers on the hunt for the genetic roots of disease, the cost of deep whole-genome sequencing makes it challenging to conduct large genetic studies involving thousands of participants, which ...
011
Reposted by Darin Takemoto
Resist47 News @resist47.news · 11/07/2026
Claudia Sheinbaum is navigating a complex term marked by cartel violence, shifting relations with the U.S., and the enduring political influence of her predecessor. resist47.news keeps you informed. #resist47 #ClaudiaSheinbaum #MexicoPolitics #USMexicoRelations #CartelViolence
resist47.news
Sheinbaum takes on cartels, Trump and the legacy of 1968
via Al Jazeera – Breaking News, World News and Video from Al Jazeera — Claudia Sheinbaum is trying to govern on her own terms — while dealing with Trump, cartels and AMLO's shadow.
021
Reposted by Darin Takemoto
Vertebrate Genomes Project @vertebrategenomes.bsky.social · 06/07/2026
🚨 MANUSCRIPT ALERT 🚨 The VGP Phase I manuscript pre-print is now live on bioRxiv! 🧬 doi.org/10.64898/202... Over 8 years, the VGP generated reference genomes for more than 800 vertebrate species, spanning ~95% of vertebrate orders and delivering some of the highest-quality genomes ever produced.
A graphic announcing the release of the Vertebrate Genomes Project Phase 1 manuscript on bioRxiv with drawings of various vertebrate creatures.The title and author list of the VGP manuscript, "The Vertebrate Genomes Project Phase I: A global reference genome resource"A QR code linking to the pre-print of the VGP manuscript
35325
Darin Takemoto @dtake01.bsky.social · 06/07/2026
Three wrongs... is an average week in FIFA-world www.espn.com/soccer/story...
espn.com
FIFA reject Belgium request; Balogun still clear to play vs. Belgium
FIFA has ruled a request from the Belgium federation for an explanation of Folarin Balogun's suspended red card as "inadmissible," meaning they have no grounds to appeal the decision and the U.S. forward remains cleared to play against them Monday.
000
Reposted by Darin Takemoto
NEJM.org @nejm.org · 01/07/2026
A new review summarizes advances in the treatment of multiple sclerosis, with emphasis on effective disease-modifying therapies for relapsing disease and the need for better treatments to prevent progression and rebuild myelin. Read the full review: nej.md/3SDJGcn
This image is a scientific illustration from a Review Article titled "Advances in Multiple Sclerosis." It has two main sections: Pathologic Features and Immune Mechanisms. Each section features diagrams with descriptive labels and visual elements.
063
Darin Takemoto @dtake01.bsky.social · 30/06/2026
The most commonly used coffee plants do not tolerate higher temperatures (arabica) or drought (robusta) induced by climate change. Scientists are looking for ways to save coffee from climate change. www.nature.com/articles/d41...
nature.com
Coffee is under threat: how scientists are fighting to save it from extinction
Coffee plants are critically endangered by climate change. Researchers are finding solutions to keep scientists supplied with their favourite discovery fuel.
010
Darin Takemoto @dtake01.bsky.social · 26/06/2026
The AI companies peddled an economic apocalypse for ordinary workers as a feature, and they wonder why everyone hates them. paulkrugman.substack.com/p/why-does-e...
paulkrugman.substack.com
Why Does Everyone Hate AI?
It’s the fear, the enshittification, datacenter hostility, and the tech broligarchy
000
Reposted by Darin Takemoto
Science X / Phys.org @sciencex.bsky.social · 25/06/2026
Medical AI privacy attacks identified targeted individuals with almost no error. Underrepresented groups appeared disproportionately vulnerable, especially when models encoded more distinctive data. doi.org/hb8prf
techxplore.com
Medical data of minorities could be more vulnerable to cyberattack
Individuals whose data are used to train medical artificial intelligence (AI) models may be at risk of being identified in cyberattacks, according to a Nature paper.
021
Darin Takemoto @dtake01.bsky.social · 25/06/2026
UnitedHealth, Humana, and CVS Health (the parent company of Aetna) denied over 70% of long-term hospital requests and over 50% of rehabilitation requests in their Medicare Advantage plans, according to a recent government report medicalxpress.com/news/2026-06...
medicalxpress.com
UnitedHealth, Humana and CVS denied post-hospital care at some of the highest rates
The three largest Medicare Advantage insurers turned down requests for post-hospital care at some of the highest rates among major plans, a federal watchdog has found.
000
Reposted by Darin Takemoto
Al Jazeera English @aljazeera.com · 23/06/2026
Zohran Mamdani says AIPAC's has been supportive of a 'status quo for immorality' in Palestine, wider region.
aljazeera.com
NYC Mayor Zohran Mamdani doubles down on criticism of AIPAC
Zohran Mamdani says AIPAC's has been supportive of a 'status quo for immorality' in Palestine, wider region.
1030457
Reposted by Darin Takemoto
Eric Topol @erictopol.bsky.social · 22/06/2026
Two of the most important biomedical breakthroughs came from science of the Gila lizard venom (GLP-1s) and yogurt (CRISPR genome editing). "The system that turned that lizard into a medicine is now being dismantled." gift link nytimes.com/2026/06/20/o...
6209111
Reposted by Darin Takemoto
Science X / Phys.org @sciencex.bsky.social · 21/06/2026
1489 CE is now the most likely date for the Llullaillaco capacocha burial. That narrower timing suggests the ceremony may have served political purposes as well as religious ones. doi.org/hb8bxn
phys.org
Human sacrifice in Inca Empire may have been driven by political motives, not religion
Three decades ago, researchers working atop the Llullaillaco volcano, located on the border between Argentina and Chile, discovered exceptionally well-preserved remains.
063
Reposted by Darin Takemoto
Eric Topol @erictopol.bsky.social · 17/06/2026
Academic freedom assessment across the world. The US is on a steep decline, below >120 countries www.scientificamerican.com/article/see-...
11400218