Sign in

David Shaywitz

@dshaywitz.bsky.social
1.7K followers 99 following 2K posts

Physician-scientist | Executive Advisor | Biomedical innovation + health technology | Chief Medical Scientist, Lore | Agency + health | HMS DBMI | AEI | davidshaywitz.com

PostsRepliesMedia
David Shaywitz @dshaywitz.bsky.social · 1h
Very interesting, via Alex Z Cc @dereklowe.bsky.social @andrewedunn.bsky.social
031
David Shaywitz @dshaywitz.bsky.social · 1h
share.google/qTUd1EbSHHQm...
share.google
YouTube
010
David Shaywitz @dshaywitz.bsky.social · 2h
Thoughtful, sobering assessment of current state of sickle cell understanding and treatment via @adrianwoolfson.bsky.social’s characteristically elegant book review in @science.org lnkd.in/p/gZ6WRvZE
000
David Shaywitz @dshaywitz.bsky.social · 7h
Related - from wsj - why personal AI agents are (mostly) good (until they're not....) -> (gift link) www.wsj.com/tech/ai/ai-a...
wsj.com
Personal AI Agents Are Great—Until They Share Your Bank Statement in the Work Chat
These hyperactive helpers can sometimes overshare, overpromise and overpurchase.
000
David Shaywitz @dshaywitz.bsky.social · 7h
Hey @gilman.bsky.social - look what I (and by "I," I mean my ChatGPT agent) made for you: bar-gilman.airybass2.chatgpt.site Good shabbos!
bar-gilman.airybass2.chatgpt.site
Bar Gilman · A cocktail album
Three years behind the bar. Explore Michael Gilman’s cocktails, recipes and experiments — collected with an AI agent.
310
David Shaywitz @dshaywitz.bsky.social · 14h
Gorgeous time for early autumn morning jog in Boston suburbs… @hjluks.bsky.social @phylogenomics.bsky.social @carolynbertozzi.bskyverified.social
020
David Shaywitz @dshaywitz.bsky.social · 07/10/2026
I-g-n-o-r-e
000
Reposted by David Shaywitz
Max Roser @maxroser.bsky.social · 06/10/2026
The share of children who died before they were 5 years old in 1950 and 75 years later. Africa: 33% ↘ 6% Asia: 25% ↘ 2.5% Oceania: 9.3% ↘ 2% Latin America: 21% ↘ 1.5% Northern America: 3.8% ↘ 0.6% Europe: 10.5% ↘ 0.4% Globally: 23% ↘ 3.5%
8417143
David Shaywitz @dshaywitz.bsky.social · 05/10/2026
Another incredibly relatable article from @bethteitell.bsky.social … www.bostonglobe.com/2026/10/05/l...
bostonglobe.com
Two kids, 12 apps, and zero clue? Welcome to the platformization of school, sports, and life, parents. - The Boston Globe
School updates. Sports schedules. Lunch menus. There’s an app for that — and parents are losing it.
000
David Shaywitz @dshaywitz.bsky.social · 05/10/2026
For those interested in learning more about some of this captivating work and the people behind it…I reviewed Karl Deisseroth’s “Projections” for @wsj.com in 2021. Gift link: www.wsj.com/arts-culture...
wsj.com
010
David Shaywitz @dshaywitz.bsky.social · 05/10/2026
@maggieastor.bsky.social cc
000
David Shaywitz @dshaywitz.bsky.social · 04/10/2026
Also, while probably not your style, you probably could easily have agent go through your bluesky posts, extract cocktail images and associated text, and have it mock up a calendar for you
100
David Shaywitz @dshaywitz.bsky.social · 04/10/2026
You are ready to market a cocktail a day 2027 calendar!
111
Reposted by David Shaywitz
Drug Monkey @drugmonkey.bsky.social · 02/10/2026
Burrowing owls are very disappointed in everything they observe.
95812
David Shaywitz @dshaywitz.bsky.social · 02/10/2026
020
David Shaywitz @dshaywitz.bsky.social · 02/10/2026
Here's the pix of Adam the Woodworker!
010
David Shaywitz @dshaywitz.bsky.social · 02/10/2026
Holy cow - what a great @statnews.com @pharmalot.bsky.social mini profile (and super cool pix) of my brother Adam highlighting his hobby in woodworking! www.statnews.com/pharmalot/20...
statnews.com
Up and down the ladder: The latest comings and goings
From new hires to departures, promotions and transfers, here are the latest comings and goings in the pharmaceutical industry.
020
David Shaywitz @dshaywitz.bsky.social · 02/10/2026
I really liked this LI post from Dr. Tania Elliott because it's a great eg of what high agency looks like in practice; often on LI (& elsewhere), we just see humblebrags about good stuff that seems to just happen to people; here she shows us the intensity of consistent effort behind it.
000
David Shaywitz @dshaywitz.bsky.social · 01/10/2026
Extremely helpful explanation by @erictopol.bsky.social in Ground Truths of several recent publications that offer intriguing insights into science of aging-once again, he does the community a solid by translating complex papers clearly while retaining nuance erictopol.substack.com/p/loss-of-ce...
erictopol.substack.com
Loss of Cell Identity Drives Human Aging
That’s What Biological (Epigenetic) Aging Clocks Are Measuring
111
David Shaywitz @dshaywitz.bsky.social · 30/09/2026
This captures a lot of where things are headed podcasts.apple.com/us/podcast/t... agree completely Paul that you can already absolutely experience this - but also, amazing as agents are, not substitute for R&D innovators as @carolynbertozzi.bskyverified.social eloquently expressed
podcasts.apple.com
The Personal Agent Race Is Here | Anish Acharya & David Pawlan
Podcast Episode · The a16z Show · September 29 · 51m
000
David Shaywitz @dshaywitz.bsky.social · 30/09/2026
Important piece via H Krumholz on the future of doctors in age of AI - I really liked this thoughtful perspective: www.jacc.org/doi/10.1016/... @nachristakis.bsky.social @ashishkjha.bsky.social
jacc.org
Beyond Information Asymmetry in Medicine: The Changing Nature of Medical Authority and Expertise
Download article citation: If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.
010
David Shaywitz @dshaywitz.bsky.social · 30/09/2026
100% this
000
David Shaywitz @dshaywitz.bsky.social · 30/09/2026
That seems unduly negative my friend
000
David Shaywitz @dshaywitz.bsky.social · 30/09/2026
Yeah kind of what I was thinking-although I suspect he was more expressing his enthusiasm for remarkable capabilities of these agents, which I totally get - it’s wild stuff! Eg -> podcasts.apple.com/us/podcast/t...
podcasts.apple.com
The Personal Agent Race Is Here | Anish Acharya & David Pawlan
Podcast Episode · The a16z Show · September 29 · 51m
010
David Shaywitz @dshaywitz.bsky.social · 30/09/2026
This suggests to me an extraordinarily narrow and reductive view of employee capabilities… Not my experience in R&D but ymmv I suppose. @dereklowe.bsky.social @carolynbertozzi.bskyverified.social
7122
David Shaywitz @dshaywitz.bsky.social · 30/09/2026
ICYMI Monday-my @wsj.com op-ed re: underappreciated gap betw proxy health data we can measure & outcomes that matter. AI can provide soothing story that often=falsely precise, but AI also could help us develop ability to build our own narratives. www.wsj.com/opinion/when... @dereklowe.bsky.social
wsj.com
Opinion | When AI Tells a Story About Your Health, Is It True?
A well-designed system could help us understand better what we don’t know as well as what we do.
010
David Shaywitz @dshaywitz.bsky.social · 29/09/2026
Always excited to talk about AI in R&D w life science execs - particularly when venue is so congenial! @harvardmed.bsky.social
011
Reposted by David Shaywitz
David Shaywitz @dshaywitz.bsky.social · 27/09/2026
3/ A better oppy may be to use AI differently. Alia Crum's work suggests deliberately choosing how we interpret experience can improve how we respond. AI could help guide us intentionally construct our own interpretations-cultivating, rather than supplanting, agency. www.wsj.com/opinion/when...
wsj.com
Opinion | When AI Tells a Story About Your Health, Is It True?
A well-designed system could help us understand better what we don’t know as well as what we do.
021
Reposted by David Shaywitz
David Shaywitz @dshaywitz.bsky.social · 27/09/2026
2/ But surely AI can help, right? If so, not by turning uncertain or incomplete data into a seemingly coherent, falsely precise narrative -- one that feels more convincing than the evidence warrants, while encouraging us to outsource interpretation to the technology.
101
Reposted by David Shaywitz
David Shaywitz @dshaywitz.bsky.social · 27/09/2026
Short 🧵 on my new @wsj.com op-ed about measurement, meaning, and AI in health: 1/ Across personal health/wearables and pharma R&D, we can collect increasingly rich proxy measurements, yet often these can’t sustain the precision insights we want -- and increasingly expect.
201
Reposted by David Shaywitz
Jonathan Eisen @phylogenomics.bsky.social · 27/09/2026
Tailed blue and fiery skipper from my yard yesterday
Talked blue butterfly feeding at purple flowerTalked blue butterfly feeding at purple flowerFiery skipper on old butterfly bush flowerFiery skipper on old butterfly bush flower
0584
David Shaywitz @dshaywitz.bsky.social · 27/09/2026
3/ A better oppy may be to use AI differently. Alia Crum's work suggests deliberately choosing how we interpret experience can improve how we respond. AI could help guide us intentionally construct our own interpretations-cultivating, rather than supplanting, agency. www.wsj.com/opinion/when...
wsj.com
Opinion | When AI Tells a Story About Your Health, Is It True?
A well-designed system could help us understand better what we don’t know as well as what we do.
021
David Shaywitz @dshaywitz.bsky.social · 27/09/2026
2/ But surely AI can help, right? If so, not by turning uncertain or incomplete data into a seemingly coherent, falsely precise narrative -- one that feels more convincing than the evidence warrants, while encouraging us to outsource interpretation to the technology.
101
David Shaywitz @dshaywitz.bsky.social · 27/09/2026
Short 🧵 on my new @wsj.com op-ed about measurement, meaning, and AI in health: 1/ Across personal health/wearables and pharma R&D, we can collect increasingly rich proxy measurements, yet often these can’t sustain the precision insights we want -- and increasingly expect.
201
David Shaywitz @dshaywitz.bsky.social · 27/09/2026
Batshit crazy.
000
David Shaywitz @dshaywitz.bsky.social · 26/09/2026
V thoughtful perspective on this topic from @danielsodickson.bsky.social -> www.linkedin.com/posts/dan-so...
linkedin.com
Bayes' theorem is the reason most clinicians give for not scanning healthy people. I think it argues for the opposite. I was speaking in Oxford recently, at the kind invitation of my friend and… ...
Bayes' theorem is the reason most clinicians give for not scanning healthy people. I think it argues for the opposite. I was speaking in Oxford recently, at the kind invitation of my friend and colle...
010
David Shaywitz @dshaywitz.bsky.social · 25/09/2026
Timely Rachael Bedard NYT on how AI (looking at you, @openevidence.bsky.social) has made her better doctor, while increasing her concern about doctors-in-training perhaps leaning too heavily on the technology. @adamrodmanmd.bsky.social quoted. nytimes.com/2026/09/25/o... @maggieastor.bsky.social
nytimes.com
Opinion | Being a Doctor Will Never Be the Same After A.I. (Gift Article)
I’m confident in my mastery over what doctors do — and less confident about my continued mastery of an ever-evolving universe of facts.
000
Reposted by David Shaywitz
Nicholas A. Christakis @nachristakis.bsky.social · 25/09/2026
Getting tenure.
0243
David Shaywitz @dshaywitz.bsky.social · 25/09/2026
Story re: job candidate showing up to interview w ice coffee, said by some to be unprofessional. I relate-I showed up to my @mit.edu bio grad school oral prelim/qual exam w coffee in hand-was later told it registered as arrogant, & led to (even more) brutal experience. www.wsj.com/lifestyle/ca...
wsj.com
How an Iced Coffee in a Job Interview Sparked a Raging Etiquette Debate
If you’re thinking about bringing a chilled drink to an interview, recruiters and career coaches have some advice.
001
David Shaywitz @dshaywitz.bsky.social · 24/09/2026
Very substantial healthcare leader - you can get a sense of Chris Klomp in this interview w Dr. Mark McClellan (ex- @fda.gov commish) at fairly recent, and highly informative @dukemargolis.bsky.social event in DC youtu.be/nCnPEqlSL2w?... (starts at 4:59:20) @scottgottliebmd.bsky.social
youtu.be
2026 Health Policy Conference: Driving Health Policy Transformation in the Next Decade
YouTube video by Duke Margolis
010
Reposted by David Shaywitz
R. Coxeter @ruthcoxeter.bsky.social · 24/09/2026
Strolling with Central Park’s blue herons. Far from UN Week gridlock.
A blue heron at sunset A blue heron contemplates dinner in Central Park.
031
David Shaywitz @dshaywitz.bsky.social · 24/09/2026
That is amazing with all of the AI and all of the information, the targeting algorithms have integrated all of it, and somehow concluded to direct their attentions to you.
100
David Shaywitz @dshaywitz.bsky.social · 22/09/2026
Loved this and, as a devoted Pilates enthusiast, agree w intensity and quality of workout.. www.wsj.com/lifestyle/fi... Cc btone_fitness
wsj.com
Gym Bros Are Going to Pilates—and Leaving Shaking Like a Chihuahua
Low-impact workouts are testing the strength of men accustomed to bench-presses and burpees. I gave them a try. It didn’t go well.
020
Reposted by David Shaywitz
Jonathan Eisen @phylogenomics.bsky.social · 21/09/2026
And today in adorable -- Allen's Hummingbird - seen in Laguna Beach a few days ago. #birds
08217
David Shaywitz @dshaywitz.bsky.social · 20/09/2026
Finally: why I'm long-term optimistic about the preventive/preemptive health opportunities of rich data collection (molecular, wearable, imaging) - my discussion in TR of my recent Nature Digital Medicine paper w Nathan Price & @danielsodickson.bsky.social timmermanreport.com/2026/08/the-...
timmermanreport.com
The Other Side of Bayes: Rethinking False Positives in Health Screening - TimmermanReport.com
Imagine screening 10,000 apparently healthy people for a disease that affects one person in a thousand. Let’s further assume the test is fairly good: 99% sensitive and 99% specific. (In case it’s been...
000
David Shaywitz @dshaywitz.bsky.social · 20/09/2026
Here timmermanreport.com/2026/06/well... I discuss why wearable data: - Today are often precision hlth theater; - Can make you feel both worse (eg obsessive optimization) or better (eg context of constructive mindset a la Alia Crum) - May be more predictive in future (a la Nathan Price)
timmermanreport.com
Wellness Tech: Don’t Use as Directed - TimmermanReport.com
The Great Technology Plan for Wellness, to simplify only slightly, envisions a path to health that runs through data: collect more (through wearables and blood tests), analyze with AI, and deliver per...
000
David Shaywitz @dshaywitz.bsky.social · 20/09/2026
I've discussed limitations of wearable measurements in @statnews.com, @bostonglobe.com, & most recently in TR timmermanreport.com/2026/08/the-... (excerpt below); highlights exactly the evidence gap @erictopol.bsky.social rigorously details in his latest GT: erictopol.substack.com/p/the-big-ho...
000
David Shaywitz @dshaywitz.bsky.social · 20/09/2026
Great to see NYT cover topic of AI's "moral code" -> www.nytimes.com/2026/09/20/b... -> and hope future coverage includes Zak Kohane's "Human Values Project" - focused on this exact subject in context of medicine & health: hvp.global DBMI @harvardmed.bsky.social @melaniemitchell.bsky.social
nytimes.com
Who Gets to Decide A.I.’s Moral Code? (Gift Article)
A small number of people are shaping what chatbots value. Those choices are already influencing how people think.
000
Reposted by David Shaywitz
Jonathan Eisen @phylogenomics.bsky.social · 19/09/2026
And in “Worst hike advertisements ever” … also they should have added “Just bring water. Snacks will be provided.”
4646
David Shaywitz @dshaywitz.bsky.social · 19/09/2026
In today's @wsj.com, my review of the final installment of Barry Werth's "Drug Wars" trilogy - surprisingly, a prequel, describing the evolution of biopharma during the mid 20th century, describing the envt (thru lens of $MRK) into which $VRTX was later born. www.wsj.com/arts-culture...
wsj.com
‘The Age of Cures’ Review: What the Pharmacist Ordered
The 20th-century advance in American pharmaceutical science was driven by a cohort of devoted researchers working with ambitious drug companies.
021