INTRODUCTION The World Health Organization supports intrinsic capacity (IC) as a framework for assessing and monitoring an older person's cognitive health. Low IC is associated with higher dementia ...

INTRODUCTION The World Health Organization supports intrinsic capacity (IC) as a framework for assessing and monitoring an older person's cognitive health. Low IC is associated with higher dementia ...

The School of Kinesiology (http://kines.umich.edu) at the University of Michigan invites applications and nominations for a tenure-track faculty position at the level of Assistant Professor, Associate...

Norris et al. demonstrate the detrimental role of intramuscular adipose tissue (IMAT) on muscle regeneration. Following injury, IMAT inhibition enhances muscle regeneration by increasing myofiber dens...

The authors report findings from the MOBILIZE trial, which found that exercise therapy and self-management support improved patient-reported quality of life in individuals with multiple chronic condit...

Background Sarcopenia represents a major clinical and societal challenge facing rapidly aging populations. Accessible and specific biomarkers represent valuable tools, both in diagnosis and assessin.....

Our findings suggest that blood Alzheimer’s disease-related biomarkers might help estimate progressive muscle strength decline among older adults, elucidating the influence of brain pathology and cogn...

INTRODUCTION Evidence suggests that engaging in a high volume of daily or weekly physical activity may reduce the risk of cognitive impairment due to Alzheimer's disease and related dementias (ADRD)...

Metabolism plays a crucial role in both aging and aging-related diseases, but the metabolites that serve as pivotal biomarkers of aging are not fully known. Sebastiani et al. analyze metabolites in pl...

Abstract. Interferon gamma (IFN-γ) is a pleotropic cytokine which is a central mediator of the immune response to pathogen infection, while also playing im

In a community-based cohort of more than 2,000 older adults from Sweden, blood biomarkers for Alzheimer’s disease were able to predict dementia up to 16 years before disease onset.

This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...

This cross-sectional study examines associations among physical activity, plasma biomarkers, and cognition in a multicenter cohort of patients with and without cognitive impairment.

Bioenergetic capacity, the ability to maintain energy balance under stress, can be monitored using blood acylcarnitine profiles. Improving this capacity may slow Alzheimer’s disease progression.

Our findings suggest that engaging in more moderate-to-vigorous physical activity might help to slow the age-related neurodegenerative process, although p-tau pathophysiology seems to mitigate the ben...

Back-to-back studies present evidence that feimin, a myokine, regulates glucose homeostasis and exercise performance. The secretory and intracellular roles of feimin provide insights into potential therapies for metabolic disease as well as for improving exercise performance.

AbstractStudy Objectives. A decline in physical functioning in older adults has been associated with a higher risk of chronic diseases. Subjective sleep di

This study provides one of the most comprehensive immune profiles of elderly individuals, uncovering high-resolution immune changes associated with aging. Our findings highlight clinically relevant im...

This study investigated BDNF's role in skeletal muscle adaptations to aerobic exercise in mice. It examined acute and chronic exercise effects on BDNF response and compared chronic BDNF treatment to ...

Abstract figure legend Prehabilitative exercise is the process of preparing, through structured exercise, for anticipated disuse (e.g. bed rest or limb immobilization). Despite positive findings in c....

The connection between the respiratory capacity of skeletal muscle mitochondria and athletic performance is widely acknowledged in contemporary resear…

Background and ObjectivesIndividuals aged 70 and older frequently experience an increased risk of deficits in both physical and cognitive functions. However, the natural progression and interrelations...

Higher mitochondrial oxidative phosphorylation assessed in skeletal muscle through non-invasive MR spectroscopy predicts less brain atrophy and microstructural deterioration in community-dwelling adul...

Frailty complicates the care of individuals with dementia, increasing their vulnerability to adverse outcomes. This Personal View presents expert recommendations for managing frailty in individuals with dementia, aimed at health-care providers, particularly those in primary care. We conducted a rapid literature review followed by a consensus process involving 18 international experts on dementia and frailty. The experts identified key areas, including diagnosis of frailty, assessment of nutritional status and nutritional management, physical activity, prevention of falls, and polypharmacy management.

Cellular senescence has been implicated in the aging-related dysfunction of satellite cells, the resident muscle stem cell population primarily responsible for the repair of muscle fibres. Despite bei...

Abstract. Biomarkers of ageing serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which speci

Dietary fructose enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer indirectly via metabolite transfer.

Madhavan et al. identify and characterize the selective regulation of protein solubility by the ketone body β-hydroxybutyrate (βHB) across a range of models. βHB exposure rescues cell-based and C. ele...