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Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto

@drpintothe2nd.bsky.social
257 followers 221 following 74 posts

[he/him] Judoka/traveler/etc; Staff Scientist at Research Institute && Research Associate at the Milwaukee Public Museum.

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Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto @drpintothe2nd.bsky.social · 27/08/2026
Tldr; MORE SEX CHROMOSOMES AND GECKO GENOMES
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Reposted by Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto
Tony Gamble @tonygamble.eurosky.social · 27/08/2026
New collaborative paper from the lab on gecko sex chromosome and genome evolution! 🧪🦎 www.science.org/doi/10.1126/...
science.org
Genomic predisposition is associated with the direction of sex chromosome evolution
Sex chromosome evolution is among the most dynamic genomic innovations in vertebrates, yet why some lineages evolve XY while others evolve ZW remains unclear. Using chromosome-level genomes from 19 ge...
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Reposted by Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto
Caitlin E. McDonough-Goldstein @ideaspermatheca.bsky.social · 17/08/2026
How do we navigate the semantic labyrinth of sex in biology? doi.org/10.1093/icb/icag093 In developing a @treeofsex.bsky.social 2.0 ontology, we have encountered many versions of sex. In this paper, we come together to explore places of contention and make connections across concepts of sex.
doi.org
Navigating the Semantic Labyrinth of “Sex” in the Study of Reproductive Trait Evolution
Synopsis. “Sex” is a compound of many different concepts that contribute to a multiplicity of meanings. As a result, “sex” appears in a wide range of scien
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Reposted by Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto
Ian Brennan @brennian.bsky.social · 19/08/2026
Have you ever seen a leaftail gecko? Maybe you thought to yourself, “damn, I wonder what’s in those genes?” If so, you’re a nerd. But good news, you’ll be interested in tomorrow’s (20 Aug @ 12pm AEST) talk by Michelle van der Sluijs on leaftail genomics! Interested in joining?
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Reposted by Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto
Corrie Moreau @corriemoreau.bsky.social · 06/08/2026
I am thrilled to share that I will join the American Museum of Natural History @amnh.org as the Dean of Collections, Curator, and Professor in September!
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Reposted by Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto
Adam Phillippy @aphillippy.bsky.social · 06/08/2026
For the past 30 years, “whole-genome sequencing” has been a misnomer. Today the T2T Consortium publishes a dozen papers heralding a future of truly complete genomes for humans and nearly any vertebrate 👨‍🔬🐒🐦🐀🦒🐎🫏🐹🐟 (sorry, no salamanders): www.cell.com/consortium/t... 🧵[1/15]
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Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto @drpintothe2nd.bsky.social · 17/07/2026
Super neat!! 🧬
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Reposted by Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto
licia @astra99.bsky.social · 24/05/2026
New *Tylosaurus rex* mosasaur reached 43 feet long! That's one big sea lizard, and a reminder of how much we're still learning about ancient life.
smithsonianmag.com
Paleontologists Discover an Ancient Marine Reptile They've Dubbed the T. Rex of the Sea, Crowning An
Scientists have identified a new species of mosasaur, named Tylosaurus rex, from fossils found in Texas. This colossal marine reptile measured up to 43 feet long and was a formidable predator that dom
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Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto @drpintothe2nd.bsky.social · 23/05/2026
Absolutely amazing, thorough, and integrative work by DR. Zietlow!!! So many congratulations!! 🎉
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Dr. Amelia R. Zietlow 🦎 @tyrantlzrdqueen.bsky.social · 22/05/2026
Everything IS bigger in Texas... Introducing TYLOSAURUS REX–“TEX”. A monster animal, a monster paper, & a monster project that I am *so* excited to finally share with everyone after ~5 yrs. Huge thanks to my coauthors, Mike & Ron, & to Alderon Games for bringing our lad to life!! #FossilFriday
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Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto @drpintothe2nd.bsky.social · 11/05/2026
"I'm under-babied and I'm proud."
static.klipy.com
Spongebob: I'm Ugly and I'm Proud
Alt: Spongebob: I'm Ugly and I'm Proud
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Molecular Biology and Evolution @molbioevol.bsky.social · 30/04/2026
@drpintothe2nd.bsky.social et al. present SCINKD as a framework to identify unannotated sex chromosomes and curate diploid genome assemblies from a single individual. 🔗 doi.org/10.1093/molbev/msag067 #evobio #molbio #compbio
doi.org
Sex chromosome identification and genome curation from a single individual with SCINKD
Abstract. In most animal species, the sex-determining pathway is typically initiated by the presence/absence of a primary genetic cue at a critical point d
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Caleb Krueger @cheloevo.bsky.social · 29/04/2026
Beautiful. Big news if you’re interested in identifying and compiling sex-determining mechanisms like me!
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Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto @drpintothe2nd.bsky.social · 29/04/2026
This work would not be possible without support from many folks, @drsimonegable.bsky.social @tonygamble.bsky.social @stuartvnielsen.bsky.social @sexchrlab.bsky.social and many others!! 🙏🏻 🙏🏻
media.tenor.com
a cartoon of a man talking on a telephone .
Alt: Professor Farnsworth (Futurama) says "Good news, everyone!"
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Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto @drpintothe2nd.bsky.social · 29/04/2026
Happy to announce two-fold news! 1) The SCINKD paper is now published in @molbioevol.bsky.social - doi.org/10.1093/molb... 2) SCINKD [v2.2.4] release has reduced runtimes (about 2x) and the revitalized mode for genomes >5Gb is now live and tested on genomes up to 21Gb! 🐸 github.com/DrPintoThe2n...
doi.org
Sex chromosome identification and genome curation from a single individual with SCINKD
Abstract. In most animal species, the sex-determining pathway is typically initiated by the presence/absence of a primary genetic cue at a critical point d
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The American Genetic Association @theaga.bsky.social · 08/04/2026
🐍 Exciting news! The first high-quality, chromosome-level genome of the mandarin rat snake (Euprepiophis mandarinus) has been assembled. This 1.65 Gb genome with 19 chromosomes offers vital insights for taxonomy, evolution, and conservation. Photo: Papas2010 (Wikimedia) 1/2
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Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto @drpintothe2nd.bsky.social · 04/04/2026
Happy to announce the alpha release of the SCINKD3! SCINKD3 is an extension of SCINKD streamlines the use of WGS data from multiple individuals to identify sex chromosomes. In testing, its shown to be robust in many cases with as few as 4 individuals. github.com/DrPintoThe2n...
github.com
GitHub - DrPintoThe2nd/SCINKD3: development repo of SCINKD (v3)
development repo of SCINKD (v3). Contribute to DrPintoThe2nd/SCINKD3 development by creating an account on GitHub.
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Mobius Stripper @mobiusstripper.bsky.social · 09/03/2026
That's because they coddle them too much now. Back in my day, it only took 20 years for T-Rexes to fully mature, because they had discipline. Spare the rod, spoil the terrible tyrant lizard. www.sciencedaily.com/releases/202...
sciencedaily.com
T. rex took 40 years to reach full size, study finds
Tyrannosaurus rex may have taken far longer to grow up than scientists once thought. By analyzing growth rings in fossilized leg bones from 17 tyrannosaur specimens and using new statistical methods, ...
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Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto @drpintothe2nd.bsky.social · 12/01/2026
Updated preprint available describing our method to identify sex chromosomes from a diploid genome, but better, doi.org/10.1101/2025...
doi.org
Sex chromosome identification and genome curation from a single individual with SCINKD
In most animal species, the sex determining pathway is typically initiated by the presence/absence of a primary genetic cue at a critical point during development. This primary genetic cue is often lo...
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Reposted by Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto
Aaron Quinlan (he/him) @aaronquinlan.bsky.social · 02/12/2025
We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen. 1/n
quinlanlab.org
Intro to Bedder – The Quinlan Lab
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Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto @drpintothe2nd.bsky.social · 11/11/2025
*me when the ACA subsidies lapse*
media.tenor.com
a cartoon of ralph from the simpsons sits in an orange seat
Alt: a cartoon of ralph from the simpsons sits alone on a bus saying "I'm in danger"
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Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto @drpintothe2nd.bsky.social · 11/07/2025
Big S/O to other folks who generated and shared their high-quality data with us (some published, some not) to help develop our understanding of the tool and framework. They truly made this work possible! Folks like @tododge.bsky.social @lngray.bsky.social @scarey.bsky.social, to name just a few 🙏🏼🦸‍♂️🦸‍♀️🧬
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Melissa Wilson @sexchrlab.bsky.social · 11/07/2025
🚨Preprint🚨 Sex chromosome identification & genome curation from a single individual with SCINKD www.biorxiv.org/content/10.1... Incredible work led by @drpintothe2nd.bsky.social in collaboration w/ @drsimonegable.bsky.social @stuartvnielsen.bsky.social @tonygamble.bsky.social SE Keating & CH Smith
Graphical overview of the biological foundations of the proposed approach. Application of SCINKD to identify XY chromosomes in the Christmas island skinkApplication of SCINKD to identify previously unannotated sex chromosomes in the Lesser electric ray.
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Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto @drpintothe2nd.bsky.social · 01/07/2025
Needs to be said: I've been studying geckos for 10 years now and have so far received a 0% discount on my car insurance.
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Blair Perry @bwperry.bsky.social · 07/06/2025
I am thrilled to announce that I will be starting my lab in the Department of Integrative Biology at Michigan State University in January 2026! I will soon be recruiting graduate students and postdocs, so stay tuned and please reach out if you know anybody that might be interested! 🐍🐻🧬
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Melissa Wilson @sexchrlab.bsky.social · 03/06/2025
Gila monsters! One of the rare venomous reptiles. A peptide in their saliva/venom, exendin-4, is the basis of GLP-1 agonists, like semaglutide, to regulate insulin. We developed the first draft sequence of the Gila monster genome and are working on updating this now with newer technology.
Dr. Melissa Wilson, wearing a black shirt with a Gila monster on it and purplish glasses, holding a replica of a Gila monster skull and smiling.
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Rebecca Sear @rebeccasear.bsky.social · 28/05/2025
Intelligence researcher Robert Sternberg on IQ tests: "Standardized tests, based on modern Western notions of intelligence, are seriously limited and narrow because modern Western notions of intelligence are seriously limited and narrow" link.springer.com/chapter/10.1...
link.springer.com
Time Bomb: How the Western Conception of Intelligence Is Taking Down Humanity
During the twentieth century, IQs rose an incredible 30 points—two full standard deviations! Higher IQs may have helped people deal better with computers, cell phones, and other technological in...
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The New York Times @nytimes.com · 24/05/2025
Since a Minneapolis police officer murdered George Floyd in 2020, the number of people killed by the police each year has continued to rise — and Black Americans are still killed in disproportionate numbers. Our data reporter explains his findings. www.nytimes.com/2025/05/24/u...
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Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto @drpintothe2nd.bsky.social · 02/05/2025
The average American has three friends.
Lizards (photo of a skink), Lizards <italics> (photo of a rattlesnake), Lizards <bold, italics> (photo of a gecko)
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Dr. Lucky Tran @luckytran.com · 28/04/2025
Deaths from heart disease down 75%, that’s NIH. Deaths from stroke down 75%, that’s NIH. HIV/AIDS no longer a death sentence, that’s NIH. 99% of FDA approved drugs in the last decade, that’s NIH. Please show this video to anyone who doesn’t understand why the NIH is so important.
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Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto @drpintothe2nd.bsky.social · 28/04/2025
This is what we're up to and couldn't be more excited about it! Come join the party! 🙂
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Melissa Wilson @sexchrlab.bsky.social · 28/04/2025
In December I accepted a position as a senior investigator at the NIH in the National Human Genome Research Institute & Center for Genomics and Data Science Research. Bringing the party in the desert to Maryland. We are hiring postdocs & postbacs! Please reach out :)
Smiling woman with brown hair, black jacket, green purse with a green baseball hat with a Gila monster on it, standing in front of a cherry tree covered in pink blossoms.
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Phil Ngo @squamate.bsky.social · 17/04/2025
Here is a little legless lizard from LA County. People often ask, how come it’s a lizard and not a snake? It really comes down to genetics, but there are some big hints in its morphology: eyelids that blink, a tail that can detach. Southern California Legless Lizard - Anniella stebbinsi #herps 🦎
A golden, worm-sized, snake-like, limbless lizard rests on an outstretched palm, with a little of the sandy substrate and a few bits of dead leaves beneath the lizard. The lizard has a very thin black line down the center of its back and its body is curved in a s-shape.
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Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto @drpintothe2nd.bsky.social · 14/04/2025
Capitalism will not save us from the problems that it helped create in the first place We need real solutions to our very real climate and biodiversity crises Hank makes great points about why what colossal is doing isnt what they publicly claim (and they know it too): youtu.be/Ar0zgedLyTw?...
youtu.be
They Didn't Make Dire Wolves, They Made Something…Else
YouTube video by hankschannel
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Riley Black 🏳️‍⚧️ 🦕 @restingdinoface.bsky.social · 07/04/2025
Dire wolves were not close relatives of gray wolves. They last shared a common ancestor more than 5 million years ago. What Colossal has done is make something new and slapped a dire wolf sticker on it, as if an organism equals a hypothetical genome.
scientificamerican.com
Dire Wolves Were Not Really Wolves, New Genetic Clues Reveal
The extinct giant canids were a remarkable example of convergent evolution
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Jacquelyn Gill @jacquelyngill.bsky.social · 07/04/2025
Colossal Bioscience did not revive dire wolves, despite a sensationalist Time Magazine cover story. Making genetically modified animals that are cosplaying as extinct species is not de-extinction.
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Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto @drpintothe2nd.bsky.social · 04/04/2025
I make up a tiny, tiny portion of the HHS contract spending. I still don't know if I'll be cut. Please don't forget that contract spending includes contract workers. These are the folks who have kept the government going through FTE expansions and reductions. They are important federal workers.
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Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto @drpintothe2nd.bsky.social · 03/04/2025
Today, G**gle search AI cited my own work to say that a species I study has the wrong number of chromosomes. Never accept AI vomit as fact.
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Nina Turner @ninaturner.bsky.social · 30/03/2025
No. Absolutely not.
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Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto @drpintothe2nd.bsky.social · 30/03/2025
Me: "Unfortunately, today isn't opposite day.." 8 yo: "Oh, dang!" Me: *whew* Me: "Yeah, big shame that.."
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Eric Blanc @ericblanc.bsky.social · 28/03/2025
How should federal unions respond to Trump's push to cancel union rights for roughly 700K workers? Seize today's media spotlight to call on hundreds of thousands of fed workers — & millions of other union members & supporters — to take to the streets on April 5 Then escalate
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🍁Capt.John E. Rock @johnerock.bsky.social · 28/03/2025
Dear Democratic Members of Congress, Stop telling me about what he's doing. We can all see it. Start telling me about what you're doing to stop it! Signed, Americans
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Eric Blanc @ericblanc.bsky.social · 28/03/2025
If you're a unionized worker looking to fight back, get in touch with your union as well as @fedworkersunited.bsky.social www.federalunionists.net/join-us
federalunionists.net
Federal Unionists Network - Join Us!
Join Us!
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jamelle @jamellebouie.net · 27/03/2025
thinking of one of abraham lincoln's great quotes this morning: "As I would not be a slave, so I would not be a master. This expresses my idea of democracy. Whatever differs from this, to the extent of the difference, is no democracy."
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The American Genetic Association @theaga.bsky.social · 26/03/2025
Did you know that the genus Prasinohaema is the only amniote (mammals/birds/reptiles) with green blood? We recently accepted an article featuring the first de novo genome assembly of a green-blooded skink, Prasinohaema aff. flavipes. Photo by (c) Donna Belder
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Heng Li @lh3lh3.bsky.social · 24/03/2025
longcallD is a new variant caller for genomic long reads. It jointly calls phased small and structural variants. Single binary, one command line for the whole process. Comparable accuracy to mainstream callers. Great work by Yan Gao. github.com/yangao07/lon...
github.com
GitHub - yangao07/longcallD: A local-haplotagging-based small and structural variant caller
A local-haplotagging-based small and structural variant caller - yangao07/longcallD
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Dr. Brendan "Doesn't-go-to-Ravenholm" Pinto @drpintothe2nd.bsky.social · 24/03/2025
media.tenor.com
the sun is shining brightly in the dark space surrounded by stars .
Alt: The Normandy SR1 (Mass Effect) passing in front of a star shining brightly behind the silhouette of a planet
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Eric Blanc @ericblanc.bsky.social · 24/03/2025
Bernie & AOC's great rallies could be even greater if they made organizing (not just mobilizing) asks Here are some ideas for what these asks could be — and how Bernie & AOC could concretely supercharge today’s incipient grassroots efforts www.laborpolitics.com/p/how-bernie...
laborpolitics.com
How Bernie’s Rallies Can Become a Mass Movement
Always make an organizing ask!
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The American Genetic Association @theaga.bsky.social · 19/03/2025
We grant EECG awards to graduate and post-doctoral researchers who are at a critical point in their research, where additional funds would allow them to conclude their research project and prepare it for publication.
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