The Review by Matthew J Burke and colleagues1 highlights the growing recognition that placebo and nocebo effects are biologically grounded phenomena capable of meaningfully influencing clinical outcom...

BACKGROUND Cognitive impairments are a hallmark of Huntington's disease (HD). METHODS Seventy-one participants (43 HD gene-expanded [HDGE], 28 healthy controls) from the HD-Young Adult Study at tw...

We're delighted that Dr Mena Farag (UCL Queen Square Institute of Neurology) was awarded the UK DRI PhD Prize on 9th December 2025 at Connectome 2025.

UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.

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Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides abu...

One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.

Advancements over the past decade in understanding vesicular monoamine transporter 2 (VMAT2) inhibitors highlight their key role in the treatment of movement and neuropsychiatric disorders. VMAT2 is c...

Promising blood-based biomarkers of neuropathology have emerged with potential for therapeutic development and disease monitoring. However, these tools will require specialist tertiary services for in...

Promising blood-based biomarkers of neuropathology have emerged with potential for therapeutic development and disease monitoring. However, these tools will require specialist tertiary services for in...

A series of digital tests, carried out via a smartphone app, could enhance the detection of disease progression in Huntington’s disease and improve the efficiency of clinical trials, finds research le...

Giboin et al. introduce a new motor score that can be used to monitor Huntington’s disease progression. Co-designed by people with Huntington’s disease and

Background Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by cognitive, neuropsychiatric and motor symptoms caused by a CAG trinucleotide repeat expansion in the ...

Background Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by cognitive, neuropsychiatric and motor symptoms caused by a CAG trinucleotide repeat expansion in the ...

Scotton et al. report distinct subtypes of atrophy progression in corticobasal syndrome identified using machine learning analysis of structural MRI scans.

UCL Discovery is UCL's open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.

A comprehensive longitudinal analysis of individuals with preclinical Huntington’s disease identifies biomarkers of neurodegeneration and somatic expansion in blood DNA, detectable years before sympto...

Subtle changes in the brain, detectable through advanced imaging, blood and spinal fluid analysis, happen approximately twenty years before a clinical motor diagnosis in people with Huntington’s disea...

A comprehensive longitudinal analysis of individuals with preclinical Huntington’s disease identifies biomarkers of neurodegeneration and somatic expansion in blood DNA, detectable years before sympto...