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Michela Leocadi

@drmichelaleocadi.bsky.social
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Reposted by Michela Leocadi
Mena Farag @drmfarag.bsky.social · 04/07/2026
A big thank you to @drmichelaleocadi.bsky.social and @hdyofeed.bsky.social for organising such a meaningful event today! If you’re able, please consider donating to support this important cause. Every contribution makes a difference - hdyo.enthuse.com/pf/huntingto...
hdyo.enthuse.com
🏃‍♀️ Run 4 HDYO Olivia (Liv) Martinez Scholarship Fund– 5K Charity Run/Walk at Battersea Park, July 4th 2026
After the success of 2025, where we raised more than £3000 thanks to generous donations, come join us again for a 5K run or walk to raise awareness of Huntington’s Disease and support the amazing work
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Reposted by Michela Leocadi
Mena Farag @drmfarag.bsky.social · 26/09/2025
Amid this week’s huge milestone in #HD treatment, I’m excited to share part of my PhD thesis + our paper published today in @movedisorder.bsky.social on CSF #PENK predicting striatal atrophy decades before clinical motor diagnosis 🔗 movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...
movementdisorders.onlinelibrary.wiley.com
Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease
Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides abu...
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Reposted by Michela Leocadi
Mena Farag @drmfarag.bsky.social · 26/09/2025
For the first time, we show that baseline CSF PENK predicts longitudinal striatal atrophy and also outperforms NfL in distinguishing HD-ISS 0 vs 1, supporting CSF PENK as a striatum-specific biomarker to enrich early HD trials and inform future preventive trial design.
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Reposted by Michela Leocadi
Mena Farag @drmfarag.bsky.social · 28/06/2025
Huge thanks to @drmichelaleocadi.bsky.social and #HDYO for organising this fantastic event! Donate now and please support young people impacted by Huntington's disease: hdyo.enthuse.com/pf/huntingto...
hdyo.enthuse.com
🏃‍♀️ Run 4 HDYO Olivia (Liv) Martinez Scholarship Fund– 5K Charity Run/Walk at Battersea Park
📅 Saturday, June 28th, 2025 | 🕘 8:30 AM | 📍 Battersea Park, London (Carriage Drive West) Come join us for a 5K run or walk to raise awareness of Huntington’s Disease and support the amazing work of
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Reposted by Michela Leocadi
UCL Huntington’s Disease Centre @ucl-hd.bsky.social · 01/04/2025
Hot off the press! Check out the second edition of the @ehdn-news.bsky.social Imaging Working Group (#iWG) newsletter! #HD #neuroimaging @drmichelaleocadi.bsky.social @rachiscahill.bsky.social @nicolahobbs.bsky.social ehdn.org/wp-content/u...
ehdn.org
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Reposted by Michela Leocadi
Rachael Scahill @rachiscahill.bsky.social · 24/03/2025
UCL HD Centre @ucl-hd.bsky.social celebrating #HDGratitudeDay. Thanks to all the families and researchers around the world who together are trying to improve lives for people with Huntington’s disease.
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Reposted by Michela Leocadi
Rachael Scahill @rachiscahill.bsky.social · 17/01/2025
Our paper in Nature Medicine is out today! Great working with @drmfarag.bsky.social & the YAS team (researchers and participants) to identify biomarkers that pave the way for preventative trials in Huntington's Disease. Thanks to @wellcometrust.bsky.social and CHDI for funding. tinyurl.com/3fde9mth
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Reposted by Michela Leocadi
Mena Farag @drmfarag.bsky.social · 17/01/2025
Excited to share my joint first-author paper (with @rachiscahill.bsky.social) published today in Nature Medicine (@natmedicine.bsky.social, @nature.com). Our findings are timely as the #HD therapeutic landscape expands toward preventive clinical trials. 🔓 Open access: www.nature.com/articles/s41...
nature.com
Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis - Nature Medicine
A comprehensive longitudinal analysis of individuals with preclinical Huntington’s disease identifies biomarkers of neurodegeneration and somatic expansion in blood DNA, detectable years before sympto...
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