Precision psychiatry aims to improve individual-patient decisions by measuring clinically meaningful heterogeneity, not by privileging any one data type, biomarker, or analytical method. This Personal...

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Strengthening social support, problem management, and behavioural activation were associated with the greatest incremental benefit within task-shared psychosocial interventions for adults with depress...

Consistent with principles of early intervention in mental health, ACCESS Open Minds implementation resulted in improved or equivalent outcomes but also shifted care towards community-based settings, ...

This systematic review synthesises the evidence on effectiveness and cost-effectiveness of interventions to support the recovery of people with psychosis in low-income and middle-income countries (LMI...

The rights of people with psychosis continue to be violated globally, often through practices that are legally and socially sanctioned, including coercive treatments and systemic discrimination. The C...

I live with three voices. They arrived one-by-one when I was in my twenties and have stayed with me in the decade since. Like many voice-hearers, I have been prescribed several antipsychotics (perphen...

Brain lithium concentrations followed serum concentrations closely across the day but aligned between regimens at the standard 12-h post-dose sampling timepoint. These findings directly inform ongoing...

The American Psychiatric Association's (APA) Diagnostic and Statistical Manual of Mental Disorders (DSM) is often referred to as the bible of psychiatry. While clinicians do not always follow its guid...

Our findings establish LLMs as promising tools for modelling affective processes relevant to human psychopathology. By reproducing key psychological phenomena, LLMs might enable the experimental inves...

For far too long, mental health services have neglected the needs of women, across the life-course. It is vital that this important women's mental health strategy is implemented as soon as possible by...

Antipsychotic–benzodiazepine combinations might be among the most effective options for rapid tranquilisation in patients with psychomotor agitation but carry a risk of hypotension, whereas haloperido...

Coercive measures (eg, restraint and seclusion) remain common in child and adolescent psychiatric and residential care despite efforts to reduce their use. We conducted a mixed-methods systematic revi...

This is a poem I wrote as a form of self expression when I was distressed. At that moment I didn’t think I’d be able to handle the pain of breathing, even for one more breath. So the thought came, to ...

Prevalences of anxiety, depression, and related mental health difficulties continue to rise across many high-income countries, while existing treatment services face growing pressures and limited capa...

Jewellery is often celebrated as a symbol of beauty, identity, and status in societies worldwide. It adorns bodies, marks milestones in lives, and carries cultural significance. But for some people, j...

Not an easy question to ask and certainly not an easy one to hear, especially when the answer is not a clear “no”. It is a question we rarely ask, except when someone's agony becomes unmistakably visi...

Since 2021, Spanish euthanasia law allows legally competent adults with a serious chronic and disabling condition, or a serious incurable illness with a reduced life expectancy to access medically ass...

The Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) is widely regarded as the gold standard observational tool for autism assessment. Its development, validation, and normative data re...

This systematic review and meta-analysis indicated a small association between antidepressants and ADHD or ASD, which was attenuated or became non-significant after adjusting for confounding factors. ...

Read the current issue of The Lancet Psychiatry, a monthly journal focussed on all aspects of psychiatry

In 2020, the International Alliance of Mental Health Research Funders (IAMHRF) mapped global mental health research funding for the first time,1 and Vikram Patel characterised the landscape as “too li...

There was some evidence that cannabinoids can reduce symptoms of cannabis use disorder, insomnia, tic or Tourette's syndrome, and autism spectrum disorder, but the quality of this evidence was general...

We developed prediction models for incident cardiometabolic disorders in young people with psychosis. The PsyMetRiC models are among the first in psychiatry to be available for routine clinical use. P...

We found no difference in social functioning over the course of 1 year among people offered a brief psychological intervention, and no evidence of cost-effectiveness. These data highlight the importan...

Despite the existence of effective public mental health interventions, global coverage remains low. Only a minority of people with mental disorders receive treatment, far fewer receive interventions t...

ImPuls shows promise as a cost-effective transdiagnostic group-based exercise intervention for improving mental health in outpatient care when added to TAU. It could be considered for implementation a...