Molecular biology; Neuroscience; Pharmacology

Chronic pain exhibits circadian rhythms in humans, but the mechanisms underlying such rhythmicity remain unclear. Here, we found daily oscillations in the nociceptive thresholds in a mouse model of ne...

Uncovering ketamine’s rapid antidepressant effects via somatostatin-expressing interneurons in the prefrontal cortex enables the identification of GPCR drug targets with antidepressant-like responses ...

Scientists have identified the brain circuits tied to placebo pain relief. Researchers have known that placebo effects can be a powerful treatment, yet the underlying neurological mechanisms have not ...

Structures of GDP-bound MOR–Gi conformational states combined with pharmacological assays show an inverse correlation between ligand efficacy and GDP affinity, where agonists decrease GDP affinity, pr...

Analyses of consummatory reproductive behaviours in male mice uncover a brain mechanism whereby an internal state can attribute a social quality to a generic touch to initiate purposeful reproductive ...

SBI-810, an arrestin-biased allosteric modulator of neurotensin receptor 1, can effectively alleviate acute and chronic pain in rodent models via peripheral and central modulation and can also mitigat...

Visual threat triggers contrasting freeze and escape defensive responses in two species of deer mice as a result of different activation thresholds downstream of the superior colliculus in the do...

This cohort study analyzes electroencephalography data from healthy participants to analyze and validate a cortical biomarker signature for pain, which comprised the measures sensorimotor peak alpha f...

The mu-opioid receptor (MOR) is a major target for the treatment of pain. However, opioids are prone to side effects which limit their effectiveness as analgesics and can lead to opioid use disorders ...