Reposted by Dong Heun Lee(이동흔)NEJM.org @nejm.org · 17/12/2025Tuberculous meningitis is often fatal, and current therapies need to be improved. In the HARVEST phase 3 trial, high-dose rifampin plus standard treatment was assessed. Full trial results: nej.md/49iiDsQ #MedSky #NeuroSky #IDSky 0117
Reposted by Dong Heun Lee(이동흔)IDWeek @idweek.bsky.social · 21/10/2025Did you miss the #IDWeek2025 session on Lassa fever? Check out our recap and more in IDWeek Daily News: www.pageturnpro.com/JHCLLC/11289... 011
Reposted by Dong Heun Lee(이동흔)Steven Pergam, MD, MPH @pergamic.bsky.social · 20/06/2025We need more antifungals, so good to see these new data. www.thelancet.com/journals/lan...thelancet.comOlorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b studyOlorofim showed efficacy and good tolerability in patients with IFD with few or no treatment options. Further studies will be needed to fully delineate the role of this new antifungal agent. 1268
Reposted by Dong Heun Lee(이동흔)Paul Sax @paulsaxmd.bsky.social · 29/04/2025One of the most challenging encounters in the outpatient practice of infectious diseases, summarized here wonderfully in @cidjournal.bsky.social by Drs. Advani and colleagues. Have already used this algorithm several times! doi.org/10.1093/cid/...doi.orgState-of-the-Art Review: Recurrent Uncomplicated Urinary Tract Infections in WomenAbstract. Over 50% of adult women experience at least 1 urinary tract infection (UTI) in their lifetime, and almost one-quarter of them will experience a r 34112
Reposted by Dong Heun Lee(이동흔)IDSA @idsainfo.bsky.social · 16/04/2025In CID, Michael R Hodges and colleagues evaluated fosmanogepix (FMGX) treatment in invasive mold diseases (IMDs) by Aspergillus spp. and rare molds in adults with limited treatment options. academic.oup.com/cid/advance-...academic.oup.comFosmanogepix for the Treatment of Invasive Mold Diseases Caused by Aspergillus Species and Rare Molds: A Phase 2, Open-Label Study (AEGIS)Fosmanogepix 1000mg IV (loading dose) and 600mg IV or 800mg oral (maintenance dose) was associated with an all-cause mortality of 25% at Day 42 with accept 062
Reposted by Dong Heun Lee(이동흔)Infectious Diseases @infectiousdz.bsky.social · 10/12/2024STOMP Study Interim analysis: - TPOXX (tecovirimat) showed no improvement in lesion resolution time vs placebo in adults with mild-to-moderate clade II mpox - Enrollment stopped in all study arms - Strong safety profile - Efficacy in severe cases not assessed www.globenewswire.com/news-release...globenewswire.comInterim Results from STOMP Study of SIGA’s Tecovirimat in Treatment of Mpox AnnouncedInterim analysis shows that tecovirimat did not improve time to lesion resolution compared to placebo in adults with mild to moderate clade II mpoxStudy... 073
Reposted by Dong Heun Lee(이동흔)Transplant Infectious Disease Journal @thetxidjournal.bsky.social · 04/12/2024So excited to have the Donor-Derived Infection Special Edition out - thanks to Stephanie Pouch and Karen Waller for being guest editors for this special edition! onlinelibrary.wiley.com/toc/13993062...onlinelibrary.wiley.comDonor‐Derived Infections: Transplant Infectious Disease: Vol 26, No S1Click on the title to browse this issue 12911
Reposted by Dong Heun Lee(이동흔)UCSF ID Fellowship @ucsfidfellowship.bsky.social · 04/12/2024We are so excited to welcome our new class of ID Fellows for next year – what an amazing group!! 0124
Reposted by Dong Heun Lee(이동흔)Ricardo M. La Hoz @ricardolahozmd.bsky.social · 30/11/2024The results of the SOT subgroup analysis of the SOLTICE Phase III RCT (Maribavir vs. IAT) are consistent with those of the overall population. > Effectiveness < Discontinuations. #TxID #IDSky #ViroSky #MedSky pubmed.ncbi.nlm.nih.gov/39613120/pubmed.ncbi.nlm.nih.govMaribavir for refractory cytomegalovirus infection (with or without resistance) in solid organ transplant recipients: subgroup analysis of the phase 3 randomized SOLSTICE study - PubMedClinicalTrials.gov; NCT02931539 DATA AVAILABILITY STATEMENT: The datasets, including the redacted study protocol, redacted statistical analysis plan, and individual participants data supporting the re... 2186
Reposted by Dong Heun Lee(이동흔)Brad Spellberg @bradspellberg.bsky.social · 30/11/2024For my inaugural post, Im proud to announce the publication of our Safer@Home care model. This is going to change how medicine is practiced. No need to admit pts "for IV antibiotics" anymore. Or just for IV diuresis in CHF. Or just for EtOH withdrawal. Etc. jamanetwork.com/journals/jam...jamanetwork.comVirtual Home Care for Patients With Acute IllnessThis cohort study compares outcomes of patients receiving care in an outpatient, virtual, home-based acute care model with outcomes of patients receiving standard hospital care. 158325
Reposted by Dong Heun Lee(이동흔)DocWoc71 @docwoc71.bsky.social · 01/12/2024On World AIDS Day, let's remember those we've lost, support those living with HIV, and continue the fight for awareness and treatment. ❤️ #WorldAIDSDay2024 #IDSky #HIVSky @idsainfo.bsky.social @hivma.bsky.social 0378
Reposted by Dong Heun Lee(이동흔)Allison Bond @allisonrbond.bsky.social · 30/11/2024Just a friendly reminder that, in light of the IV fluid shortage, switching to PO antibiotics can be a safe, effective, and patient-centered option! This is because bacteria don't care how the antibiotic gets in. Take, for example, Gram-negative rod bacteremia! 1213
Reposted by Dong Heun Lee(이동흔)Paul Sax @paulsaxmd.bsky.social · 22/11/2024Latest State-of-the-Art Review in @cidjournal.bsky.social comes from Dr. Miriam Barshak et al on ocular infections. (I had the pleasure of precepting Miriam in clinic around 20+ years ago --but who's counting! -- and she is brilliant and awesome.) @nottheogdrv.bsky.social doi.org/10.1093/cid/...doi.orgState-of-the-Art Review: Ocular InfectionsCollaborations between ophthalmologists and infectious disease specialists are critical for optimizing care of many patients with eye infections. We review 58717
Reposted by Dong Heun Lee(이동흔)Eric Meyerowitz @ericmeyerowitz.bsky.social · 26/11/2024Interesting cluster report of symptomatic individuals in NYC presumed from Entamoeba disbar, likely sexually transmitted. academic.oup.com/ofid/advance...academic.oup.comSymptomatic Entamoeba dispar Infections Among Men Who Have Sex With Men, New York City, 2018Abstract. Entamoeba histolytica is considered the primary species causing the parasitic gastrointestinal infection amebiasis. A cluster of amebiasis infect 051
Reposted by Dong Heun Lee(이동흔)Paul Sax @paulsaxmd.bsky.social · 27/11/2024Excellent thread by @dralicehan.bsky.social on this important paper in @cidjournal.bsky.social. Dramatic increase in cure with telehealth vs referral to local providers. Very concerning that telehealth coverage might soon be limited -- it's one of the silver linings of the pandemic. #IDSky 04613
Reposted by Dong Heun Lee(이동흔)Mohanad Al-Obaidi @mycosis.bsky.social · 29/11/2024 #TxID #IDSky #MedMyco pubmed.ncbi.nlm.nih.gov/39603983/pubmed.ncbi.nlm.nih.govCoccidioidomycosis Transmission Through Solid Organ Transplantation (2013-2022): A Report of the Organ Procurement and Transplantation Network ad hoc Disease Transmission Advisory Committee - PubMedDespite its rarity, donor-derived Coccidioides infection is a serious concern, particularly due to the high mortality rate in the early post-transplant period. To mitigate these risks, a thorough asse... 0133
Reposted by Dong Heun Lee(이동흔)Ricardo M. La Hoz @ricardolahozmd.bsky.social · 29/11/2024In this single-center retrospective study, @mularoni.bsky.social tested donors (3%) and recipients (8%) for HHV-8. Most of the donor-derived HHV-8-related disease manifested as KICS!! 🤯 On the other hand, most reactivations presented as KS. #TxID #IDSky pubmed.ncbi.nlm.nih.gov/39551265/pubmed.ncbi.nlm.nih.govSerologic screening and molecular surveillance of Kaposi sarcoma herpesvirus (KSHV)/human herpesvirus-8 (HHV-8) infections for early recognition and effective treatment of KSHV-associated inflammatory...Kaposi sarcoma herpesvirus/human herpesvirus-8 (HHV-8) neoplastic and non-neoplastic disease in solid organ transplant (SOT) recipients can be life-threatening. We evaluated the seroprevalence of HHV-... 0144
Dong Heun Lee(이동흔) @dongleemd.bsky.social · 29/11/2024Donor-derived Mycoplasma and Ureaplasma infections in Lung Transplant: 18% of donors tested positive. Culture had higher positive predictive value (PPV) compared to PCR. www.sciencedirect.com/science/arti... 020
Reposted by Dong Heun Lee(이동흔)Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 29/11/2024🌟"Today’s teaching point may end up as tomorrow’s myth." 🌟 Dr.Erin McCreary article 👇 #idquotes #idsky #medsky #AMSsky academic.oup.com/cid/article/... 0115
Reposted by Dong Heun Lee(이동흔)BK. Titanji @boghuma.bsky.social · 28/11/2024We will have another pandemic. The question is not if but when. Excellent viewpoint in CID from 2 veterans of #publichealth Anthony Fauci & Greg Folkers. Speakly plainly they hold no punches reflecting on HIV & COVID. We need their wisdom esp now. A must read! #IDSky academic.oup.com/cid/advance-...academic.oup.comHIV/AIDS and COVID-19: Shared Lessons from Two PandemicsThe HIV/AIDS and COVID-19 pandemics hold important lessons for preparing for, and responding to, future infectious disease outbreaks. Eight lessons common 69041
Reposted by Dong Heun Lee(이동흔)BK. Titanji @boghuma.bsky.social · 28/11/2024Don't you just love a good disease primer. Especially for neglected rare diseases we don't see in clinical practice on the daily. This #leprosy primer in nature reviews is great and comes with a snapshot summary that's very digestible. #IDSky #MedSky www.nature.com/articles/s41.... 79824
Reposted by Dong Heun Lee(이동흔)Eric Topol @erictopol.bsky.social · 27/11/2024A systematic review of 24 randomized trials for #LongCovid www.bmj.com/content/387/... open-access No drug, diet, or device intervention has supportive evidence for efficacy. CBT, rehab provided some relief of symptoms (moderate certainty). We're still in desperate need for a validated treatment! 30377120
Reposted by Dong Heun Lee(이동흔)Ilan Schwartz @germhuntermd.bsky.social · 27/11/2024Inaugural article in a new section in @cidjournal.bsky.social called “Clinical Dilemmas in Infectious Diseases” led by IDMedEd superstars Daniel Minter and Varun Phadke designed to teach clinical reasoning Rewriting the Script academic.oup.com/cid/advance-... #IDSkyacademic.oup.comRewriting the ScriptNatasha Spottiswoode, MD DPhil, Daniel J Minter, MD, Rachel Friedman-Moraco, MD; Rewriting the Script, Clinical Infectious Diseases, , ciae589, https://doi 45015
Reposted by Dong Heun Lee(이동흔)Allison Bond @allisonrbond.bsky.social · 27/11/2024Tenets of Infectious Diseases: 1. Source control, source control, source control 2. Stuff sticks to metal (and other material) 3. The drug has to get in to work (GI absorption, tissue penetration, presence of walled-off collection, etc.) 4. Antibiotics should not be anxiolytics 107618
Reposted by Dong Heun Lee(이동흔)Michael G. Ison, MD MS @michaelisonmd.bsky.social · 27/11/2024Additionally, the updated research criteria for HOPE Act transplants are out. You have 15 days to share your thoughts on the revised criteria using the instruction in the notice! www.federalregister.gov/documents/20...federalregister.govDraft Revised Human Immunodeficiency Virus (HIV) Organ Policy Equity Act Safeguards and Research Criteria for Transplantation of Organs Infected With HIVThe HOPE Act requires the Secretary of Health and Human Services (the Secretary) to develop and publish criteria for research involving the transplantation of organs from donors with HIV to recipients... 062
