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Brad Spellberg

@bradspellberg.bsky.social
1.6K followers 37 following 305 posts
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Brad Spellberg @bradspellberg.bsky.social · 29/08/2026
Congratulations @Wiki_Guidelines on publication of the latest guideline, on management of complications of persons who inject drugs! Great job team! Let's spread widely! amjmed.com/article/S0002-… @absteward.bsky.social
amjmed.com
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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 14/05/2026
“Antibiotics are among the most potent psychoactive drugs in all the pharmacopoeia. They are incredibly potent anxiolytics.They just act on the prescriber rather than the patient” -Dr. Brad Spellberg @bradspellberg.bsky.social #idquotes #idsky
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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 21/04/2026
Proud to be part of this great team led by @bradspellberg.bsky.social 🔥Our LTE is now published “Evidence Over Eminence: Rethinking Specialty Guidelines Amid the ATS–IDSA Debate.” A timely discussion on evidence vs eminence in the guidelines development. #IDsky academic.oup.com/cid/article/...
academic.oup.com
Evidence Over Eminence: Rethinking Specialty Guidelines Amid the ATS-IDSA Debate
Brad Spellberg, MD, Bassam Ghanem, PharmD MS BCIDP, Miguel Morante-Ruiz, MD, Émilie Bortolussi-Courval, RN PhD, Anil N Makam, MD MAS, Zeynep Ergenc, MD, Ni
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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 06/05/2026
Static vs. cidal: it’s not complex; it’s simply incorrect @bradspellberg.bsky.social et Al Honored to be part of this amazing group who challenges dogmas and debunk ID myths #idsky #microsky journals.asm.org/doi/10.1128/...
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Brad Spellberg @bradspellberg.bsky.social · 26/03/2026
From '23-'25 LA General Medical Center underwent a once in a generation workforce transformation, caused by fiscal & regulatory pressure. Our article describing causes & outcomes is published! Critical lessons for health systems in a time of federal uncertainty. www.dovepress.com/articles.php...
dovepress.com
| JHL | Dove Medical Press
Key lessons learned from the LA General transformation, including approaches taken to recruitment and culture change, and outcomes achieved.
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Brad Spellberg @bradspellberg.bsky.social · 02/03/2026
Hey @infectedterran.bsky.social, my brother in Scrubs! Have you seen it yet? Man, just watched the first episode and it was like coming home after a long journey. I really missed them, and the tone was just perfect. Whaddaya think?
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Brad Spellberg @bradspellberg.bsky.social · 01/02/2026
Rock on my brother in ampho-hating! @drboulware.bsky.social
media.tenor.com
a blue circle with a white hand making a call me gesture
ALT: a blue circle with a white hand making a call me gesture
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Brad Spellberg @bradspellberg.bsky.social · 21/01/2026
0 reason to think things would be difft in non HIV, children, xenomorphs, non carbon based life forms, or any other excuses stubborn deniers have. My suggestion? Do some yoga. Meditate. Light incense. Relax. And stop torturing your patients with 2 weeks of amphoterrible. Subtle as always, I know.
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Brad Spellberg @bradspellberg.bsky.social · 21/01/2026
And a congratulations to the humble @drboulware.bsky.social, who published a thoughtful editorial accompanying the study. Dr. Boulware is a true leader in ID, and it is an honor to have him evaluate our study. I encourage everyone to read his team's editorial! jamanetwork.com/journals/jam...
jamanetwork.com
Single-Dose Amphotericin B for HIV-Related Cryptococcal Meningitis
Cryptococcal meningitis remains a life-threatening opportunistic infection among people with advanced HIV, even in high-resource settings. For decades, the standard induction regimen in the United Sta...
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Brad Spellberg @bradspellberg.bsky.social · 21/01/2026
Thank you my friend! Based on your original work!!!! US docs gotta get on board & stop pretending things that work in other countries won't work in US. AMBITION protocol is MUCH safer and MUCH more patient centered, and just as effective as 2 weeks of old, sad, amphoterrible. @absteward.bsky.social
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Dr. D Boulware, MD MPH @drboulware.bsky.social · 21/01/2026
Patient-directed discharges (i.e. leaving against medical advice) dropped from 35% to 12%. Major congratulations to the authors: Devin Clark, Brad Spellberg @bradspellberg.bsky.social , and colleagues.
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Dr. D Boulware, MD MPH @drboulware.bsky.social · 21/01/2026
In an excellent study of real world outcomes in LA General Medical Center, after implementing AMBITION single dose liposomal amphotericin protocol for crypto meningitis: Similar survival without recurrence Fewer severe adverse events Shorter hospitalization (lower cost) dx.doi.org/10.1001/jama...
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Dr. D Boulware, MD MPH @drboulware.bsky.social · 21/01/2026
Is It Time to Use Single-Dose Amphotericin B for HIV-Related Cryptococcal Meningitis in the USA? The answer is yes! doi.org/10.1001/jama...
doi.org
Single-Dose Amphotericin B for HIV-Related Cryptococcal Meningitis
Cryptococcal meningitis remains a life-threatening opportunistic infection among people with advanced HIV, even in high-resource settings. For decades, the standard induction regimen in the United Sta...
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USC/LA General ID Fellowship Program @lageneral-id.bsky.social · 22/12/2025
Behind the scenes 🔥🔥 with all the laughs on the latest Febrile Podcast @febrilepodcast.com with @lageneral-id.bsky.social and @bradspellberg.bsky.social #IDSky player.captivate.fm/episode/dd68...
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Infected Terran @infectedterran.bsky.social · 10/12/2025
Highly recommend you check out @bradspellberg.bsky.social book "Broken, bankrupt and dying". Achieving universal coverage can be done in many different ways. The rest of the developed world has done it in all different ways (government coverage, private/public, state subsidized etc).
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Brad Spellberg @bradspellberg.bsky.social · 08/12/2025
Hasn't been much discussion of the 40% failure rate to fill ID programs this match year. Interesting. Wonder if anyone is ever going to do anything about that?
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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 03/12/2025
🆕🎙️🔥Febrile Podcast just dropped! ✅ID Jedi @bradspellberg.bsky.social ✅Mini-cases OM,IE,Bacteremia ✅IV vs PO debates ✅Duration of therapy ✅Shmidelines Vs WikiGuideline ✅A must-listen for every antibiotic steward! #IDsky #EMIMCC febrilepodcast.com/episodes/ open.spotify.com/episode/6dkJ...
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Febrile @febrilepodcast.com · 01/12/2025
New episode out today: Listen in to this team from LA as they walk through several mini-cases and chat IV vs PO antibiotics! Feat: Fourth year medical student Hannah Chute, Dr. Paloma Reta-Impey, and @bradspellberg.bsky.social Also check out: www.bradspellberg.com/oral-antibio... #IDsky #MedSky
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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 19/11/2025
🆕🔥🦴 Our 2025 Update to @wiki-guidelines.bsky.social for the Management of Pyogenic Osteomyelitis in Adults 🌟 @bradspellberg.bsky.social 🔗 [link] #idsky www.amjmed.com/article/S000...
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Brad Spellberg @bradspellberg.bsky.social · 18/11/2025
Thrilled that another regulatory innovation out of LA General is now out in @jamanetworkopen.com! The first hospital in California authorized by CDPH to administer outpt hemodialysis for up to 2 weeks for inpatients newly started on HD who lack insurance. jamanetwork.com/journals/jam...
jamanetwork.com
Hospital Hemodialysis Unit Flexibility and Hospital Length of Stay
This quality improvement study evaluates the association of hospital length of stay with a first-in-state model in which an inpatient hemodialysis unit received regulatory approval to provide temporar...
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wiki-guidelines.bsky.social @wiki-guidelines.bsky.social · 03/11/2025
📢📢📢 We are delighted to announce that we are assembling team for our next project, Pharyngitis WikiGuideline Join us to create guidelines with the humility of uncertainty. Deadline to sign up is November 21, 2025.
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Brad Spellberg @bradspellberg.bsky.social · 05/09/2025
Thanks to @abimfoundation.bsky.social ation for posting the video of my recent lecture on the LA General Policy to Override Policies. For those of you who know my lectures, this one is among the most entertaining. And it's only 10 min. Check it out & implement the policy! youtu.be/RuKAKH8A604?...
youtu.be
Administrator/Clinician Collaboration: Policies to Put Patients First
YouTube video by ABIM Foundation
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James Wilson, DO, FACP, FAWM, CTropMed @jameswilsondo.bsky.social · 22/08/2025
Another plug for #wikiguidelines @bradspellberg.bsky.social When guidelines don’t keep up with medicine
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Sébastien Poulin @sebpoule.bsky.social · 13/08/2025
Me reading DOTS trial #IDsky #DOOR
media.tenor.com
a man in a black shirt is standing in front of a door
ALT: a man in a black shirt is standing in front of a door
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Sébastien Poulin @sebpoule.bsky.social · 14/08/2025
I love Dalba I just don’t know why we should do a PhD in statistics to understand a trial now Or maybe am just getting old and grumpy
media.tenor.com
a white monkey with a blue face is sitting on a blue blanket .
ALT: a white monkey with a blue face is sitting on a blue blanket .
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𝐑𝐚𝐥𝐩𝐡 𝐌𝐨𝐡𝐭𝐲 𝐌𝐃 𝐌𝐏𝐇 @rmohty.bsky.social · 12/08/2025
As @bradspellberg.bsky.social would say CRP is missing a letter as a test "A" (CRAP) - www.sciencedirect.com/science/arti...
sciencedirect.com
Revisiting diagnostics: erythrocyte sedimentation rate and C-reactive protein: it is time to stop the zombie tests
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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 11/08/2025
International guidelines recommend 5 to 7 days of antibiotic prophylaxis for patients with cirrhosis & upper GI bleeding. 🆕🔥Systematic Review ( 14 RCTs, N=1322) & Bayesian Meta-Analysis challenged this universally held dogma #idsky jamanetwork.com/journals/jam...
jamanetwork.com
Prophylactic Antibiotics for Upper Gastrointestinal Bleeding in Patients With Cirrhosis
This systematic review and meta-analysis evaluates the evidence supporting the current guidelines antibiotic prophylaxis use in patients with cirrhosis and upper gastrointestinal bleeding.
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ID:IOTS Podcast @idiots-pod.bsky.social · 09/08/2025
#IDsky The Infectious Disease Brad Boy himself, @bradspellberg.bsky.social , has an updated Oral vs IV table, now including the Plague (Y really) and Lyme! Link here: www.bradspellberg.com/oral-antibio...
bradspellberg.com
Oral Antibiotic RCTs | mysite
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wiki-guidelines.bsky.social @wiki-guidelines.bsky.social · 03/08/2025
WikiGuidelines lapel pins are available for purchase on WikiGuidelines website: www.wikiguidelines.org Support us to incorporate humility of uncertainty into guidelines!
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Rossana Rosa @drrossanarosa.bsky.social · 10/07/2025
“We’re asking the wrong question. Let’s use fundamental PK. Let’s get the drug to where the bug is, at a high enough concentration to kill the bug, and not worry about whether we label the drug static or cidal”. As said by @bradspellberg.bsky.social 🤩😇 Fabulous conversation! #IDSky #MedSky #AMSSky
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Brad Spellberg @bradspellberg.bsky.social · 03/07/2025
Really compelling story by @corinnepurtill: "Strangers in the middle of a city: The John and Jane Does of L.A. General Medical Center". This short video tells the powerful story of the unidentified admissions to one of the busiest trauma centers in the US. www.latimes.com/00000197-c35...
latimes.com
LA Times Today: Strangers in the middle of a city: The John and Jane Does of L.A. General Medical Center
Watch L.A.
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josh farkas 💊 @pulmcrit.bsky.social · 26/06/2025
Great article on dogma in ID (with parallels to critical care) We have HUGE problems re: guidelines making recommendations & *redefining* entire diseases based on minimal data. Gov't metrics exacerbate this further. @bradspellberg.bsky.social @absteward.bsky.social @drtoddlee.bsky.social #EMIMCC
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Infected Terran @infectedterran.bsky.social · 26/06/2025
Oh snap! I hope this conversation happened near a hospital that has a burn unit @bradspellberg.bsky.social
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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 24/06/2025
How much evidence is needed to revise established clinical practices? and, can data alone truly catalyze such shifts? Our 🆕🔥 Article at @cidjournal.bsky.social with 🌟s @bradspellberg.bsky.social Practicing With Intent: How to Teach an Old Dogma New Tricks #IDSky academic.oup.com/cid/article/...
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Brad Spellberg @bradspellberg.bsky.social · 23/06/2025
Thank you to @jamanetworkopen.com for publishing economic analysis of our Safer@Home virtual acute care program! Modeling shows simple reimbursement would enable a win-win-win: patients get better patient-centered care, hospitals save money/free beds, and payors save! jamanetwork.com/journals/jam...
jamanetwork.com
Health Economic Analysis of an All-Virtual, At-Home Acute Care Model
This economic evaluation estimates hospital and payer costs associated with an all-virtual, at-home acute care program.
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Jake Scott, MD @jakescottmd.bsky.social · 06/06/2025
The work has been deeply collaborative. The idea to crowdsource controlled vaccine trials came from @bradspellberg.bsky.social, and we've had a phenomenal team - @abhaydhand.bsky.social, @alejodiaz81.bsky.social, Dr. Ali Meza Vazquez, Neal Fox, and help from many contributors from around the world.
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wiki-guidelines.bsky.social @wiki-guidelines.bsky.social · 05/06/2025
#JoinTheMovement #MedicalScience #ClinicalResearch #RCTmatters #HealthcareInnovation #MedEd #WikiGuidelines
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wiki-guidelines.bsky.social @wiki-guidelines.bsky.social · 05/06/2025
Your Role: Review existing guidelines across all specialties to evaluate whether or not recommendations are based on high-quality, adequately powered, peer-reviewed, and publicly accessible prospective studies, including at least one randomized controlled trial
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wiki-guidelines.bsky.social @wiki-guidelines.bsky.social · 05/06/2025
📢📢📢Join our team appraising the level of evidence used to make consensus guideline recommendations across all specialties Deadline to sign up: 6/20/25 New to WikiGuidelines? Use the link below to complete WikiGuidelines New Participant application. forms.office.com/r/Tyb8R0iM8X
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Brad Spellberg @bradspellberg.bsky.social · 29/05/2025
Amazing job, summarizing 260 RCTs of vaccines with nearly 2.5 million patients randomized! We will turn this into a peer reviewed manuscript, but the table summarizing the trials can be seen on the web: www.bradspellberg.com/vaccine-rcts
bradspellberg.com
Vaccine RCTs | mysite
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Jake Scott, MD @jakescottmd.bsky.social · 29/05/2025
Just wrapped data extraction for our global vaccine RCT review: 260 trials (1951 to 2025) 2,468,751 trial participants Possibly the most comprehensive dataset of its kind. Huge thanks to the team that powered through to this milestone. @bradspellberg.bsky.social docs.google.com/spreadsheets/d…
docs.google.com
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Brad Spellberg @bradspellberg.bsky.social · 27/05/2025
LA General is seeking a Director of Inflammatory Bowel Disease and Director of GI Ambulatory Care in the Division of Gastroenterology and Hepatology. See job description attached!
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Brad Spellberg @bradspellberg.bsky.social · 25/05/2025
Thanks to @absteward.bsky.social for finding the most recent Shorter is Better: TB Is Complex Study. Shows 8 week regimens are inferior to 24 week for cure. Sets a lower boundary for TB. Slides and website updated. www.bradspellberg.com/shorter-is-b...
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Jake Scott, MD @jakescottmd.bsky.social · 25/05/2025
Our crowd-sourced spreadsheet of controlled vaccine RCTs just hit 189 trials - spanning Adenovirus to Zika & 2.1 million participants. Every row links to the primary paper. More to come... docs.google.com/spreadsheets/d… @bradspellberg.bsky.social @apnews.com @statnews.com @nytimes.com
docs.google.com
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Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 23/05/2025
The results of this study call into question the accuracy of susceptibility testing for organisms containing MBLs when conducted in nutrient-rich media and reiterate the need for clinical validation of in vitro susceptibility testing results #idsky
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Joanna Schaenman, MD, PhD @jschaenmanmd.bsky.social · 16/05/2025
This is a great way to characterize these tests as 'zombies' 😨 Hard to get folks to stop ordering these tests despite the lack of data , especially in immunocompromised patients! @idsensei.bsky.social @bradspellberg.bsky.social @ast-idcop.bsky.social
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Jake Scott, MD @jakescottmd.bsky.social · 12/05/2025
Grateful to @cidrap.bsky.social & @mtosterholm.bsky.social highlighting our vaccine RCT table in this viewpoint. This kind of recognition reinforces the value of collective, evidence-based efforts to bring clarity to vaccine research. @bradspellberg.bsky.social www.cidrap.umn.edu/anti-science...
cidrap.umn.edu
Viewpoint: Proposed system for vaccine approval, safety monitoring begs crucial questions
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Brad Spellberg @bradspellberg.bsky.social · 12/05/2025
This may be of interest @mtosterholm.bsky.social @cidrap.bsky.social
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Jake Scott, MD @jakescottmd.bsky.social · 12/05/2025
Fresh #s from our crowd-sourced, verifiable vaccine trial dataset: bit.ly/4mbdl6U - 123 controlled trials (polio to chikungunya) - 1.9 million participants - ~80% placebo, 15% active control (used only when placebo would be unethical) Every entry links to primary source @bradspellberg.bsky.social
bit.ly
Placebo-Controlled Vaccine RCTs (Living List)
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Jake Scott, MD @jakescottmd.bsky.social · 12/05/2025
Folks from around the world came together (off the clock, with no funding) not to argue, but to illuminate. Grateful to @bradspellberg.bsky.social, @abhaydhand.bsky.social, @adamlauring.bsky.social, Neal Fox, @jkeelan57.bsky.social, @alejodiaz81.bsky.social, & many other contributors bit.ly/44zoJDm
bit.ly
Vaccine RCTs | mysite
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