For decades, children have sent Highlights magazine their drawings, poems, questions and concerns. Now Highlights is turning 80. We took a look back at the beloved magazine's history.

An expert at the University of Copenhagen said his team had been sharing its research with the company’s A.I. model, Claude, and that its new finding matched their work.

Respiratory syncytial virus (RSV) is associated with high morbidity in solid organ transplant recipients (SOTRs) and the effectiveness of the RSV vaccine in this population is unknown. We sought to as...

This study provides preliminary evidence supporting the clinical relevance of host-directed immunotherapy as an adjunct to antifungal treatment in severe invasive mold diseases (IMDs), which remain as...

Diagnosis of coccidioidomycosis can be challenging with conventional diagnostics and may require collection of an invasive specimen. This study showed that

This retrospective cohort from a US transplant center found a high incidence of Chagas disease reactivation with overall favorable 2-year outcomes. Most reactivations occurred early post-transplant, ...

Why aren’t we using it?

A daring 10-day voyage will take four astronauts on a loop around the moon and set the stage for future forays to the lunar surface

Infection with Japanese encephalitis virus, a mosquito-borne flavivirus, was identified in a patient who received a liver transplant from a donor who resided in California.

In this randomized, controlled trial of patients with nontuberculous mycobacterial pulmonary disease caused by Mycobacterium abscessus, symptom and microbi

Severe coccidioidomycosis carries high mortality despite antifungals. We treated 18 refractory cases with immune modulation, including augmentation of Type

<em>L. pneumophila</em> Infection Linked to Water Flosser

Utilizing a modified Delphi process, 53 fungal experts from 16 countries developed consensus endpoints for clinical trials targeting invasive candidiasis,

New bloodstream infections after day 3 of febrile neutropenia (FN) were uncommon in patients with cancer and hematopoietic cell transplant (HCT) recipients

Aspergillus species are a major cause of fungal-related morbidity and mortality worldwide, particularly among individuals with chronic obstructive pulmonary disease (1), patients in intensive care uni...

This first report of olorofim use in real-world clinical practice highlights the promising efficacy and good tolerability of olorofim in patients with inva

Invasive pulmonary aspergillosis (IPA), once limited to immunocompromised patients, is now a severe complication in critically ill ICU patients without classic risk factors.

Objective A growing body of evidence points to a role for herpesviruses in the development of Alzheimer’s disease (AD) and a reduced risk of AD among patients receiving antiherpetic medications. We in...

Introduction The yeast Candida vulturna is a member of the Candida haemulonii species complex, like its close relative Candida auris. Members of this species complex, including C. vulturna, often di...

Ancient genomes reveal that a bacterial fever jumped from human-borne ticks to lice around the time wool textiles became common.

Official website for the University of Miami Leonard M. Miller School of Medicine

An abstract is unavailable.

Invasive fungal infections (IFIs) significantly impact morbidity and mortality in kidney transplant recipients (KTR), but their effect on allograft fu…

Imagine you’re birdwatching in the Costa Rican rainforest, Merlin app in hand. A flash of iridescent blue catches your eye. You scan the canopy and whisper excitedly: Look, it’s the elusive Blujepa! A...

A drug candidate with a new mechanism of action shows promise against several drug-resistant infections in mice

A T-cell therapy developed by Orca Bio, a private biotech company, significantly reduced the risk of a debilitating immune reaction in patients with several types of blood cancer.

Valley fever (VF) is a common cause of community acquired pneumonia in the American Southwest. Diagnosis is challenging due to VF’s similarities to other pulmonary diseases. The VF T-cell response is important to control the disease and measuring this response holds promise as an improved diagnostic.ObjectiveIdentification of VF T-cell epitopes and development of disease diagnostics and efficacy monitoring for vaccine trials.MethodsWe identified VF specific T-cell epitopes by using their ability to bind the Major Histocompatibility Complex Class II (MHC II) molecules and T-cell stimulation. We performed MHC binding prediction on known and unknown Coccidioides antigens and then empirically tested the predictions on unknown antigens with an in vitro multiplex MHC binding analysis. Peripheral blood mononuclear cells from clinical Coccidioides infections, and endemic or nonendemic healthy controls were stimulated with the identified peptides and evaluated for immunologic memory responses.ResultsA total of 108 Coccidioides peptides were identified by MHC class II binding. The 108 peptides (NAU108) were synthesized, pooled, and jointly evaluated for immunogenicity in VF positive individuals. The peptides re-activated memory CD4+ T-cells in VF confirmed and endemic VF specimens when compared to non-endemic control samples as determined by activation marker and cytokine secretion.ConclusionThis study identified peptides that when pooled had immunogenic properties in humans infected with Coccidioides that can be used to distinguish infected individuals from endemic area healthy controls or non-exposed individuals outside the endemic area. This approach holds relevance for the development of diagnostic assays for VF.

The interim results demonstrated a slightly better vaccine effectiveness in individuals who are immunocompetent vs immunocompromised individuals.

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