We herein present a bioinspired divergent total synthesis of all five canonical sparteine and lupinine alkaloids: sparteine, α-isosparteine, β-isosparteine, lupinine, and epilupinine. Our approach emu...

Three-component thio- and carbo-boration reactions to form functionalised benzoxaborinines and benzazaborinines are reported. The nucleophile scope includes thioethers, thiols, and (hetero)arenes. Me...

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Small organic rings are important molecular entities that have long played a crucial role in organic synthesis and medicinal chemistry. Similarly, small inorganic rings have shown promise in promoting...

Applications are invited for a Postdoctoral Research Associate position to work under the supervision of Prof. Andrew Lawrence on a project funded by the Leverhulme Trust.

2,6-Di-tert-butyl substituted pyridines (tBu2-py) are widely used non-nucleophilic Brønsted bases. Their ubiquity is due to their highly hindered basic site and chemically robust nature. Herein we re...

Saturated heterocycles are commonly adorned with groups that influence their biological properties. Synthetic methods that transpose existing substituents on saturated heterocycles to multiple peripheral positions are therefore highly valuable. In this ...

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Mechanistic analysis revealed the iron-catalysed C−H borylation of 2-phenylpyridine derivatives with 9-borabicyclo[3.3.1]nonane ([H-B-9-BBN]2) operates through hidden catalysis with the iron salt med...

Borane-mediated deoxyfluorination of in situ generated N-H-O-alkyl-isoureas using Et3N ⋅ 3HF represents a novel approach to achieve a highly 2°-alcohol-selective substitution in preference to benzyli....

Organofluorine compounds are vital across multiple sectors, hence highly selective methods to install fluorine are of considerable importance. The deoxyfluorination of alcohols is a key approach to p...

Organofluorine compounds are vital across multiple sectors, hence highly selective methods to install fluorine are of considerable importance. The deoxyfluorination of alcohols is a key approach to p....

High-valent nickel species are implicated as intermediates in industrially relevant chemical transformations and in the catalytic cycles of metalloenzymes. Although a small number of tetravalent NiX4 ...

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Oxoboranes (R-BO) are transient species that rapidly trimerise to form boroxines. To date, the only method used to stabilise oxoboranes is to add a Lewis base, but this forms a three-coordinate at bo...

PhD Project - A Skeletal Editing Approach to Silicon-Switch Molecules at Heriot-Watt University, listed on FindAPhD.com