We herein present a bioinspired divergent total synthesis of all five canonical sparteine and lupinine alkaloids: sparteine, α-isosparteine, β-isosparteine, lupinine, and epilupinine. Our approach emu...

Applications are invited for a Postdoctoral Research Associate position to work under the supervision of Prof. Andrew Lawrence on a project funded by the Leverhulme Trust.

The quinol–enedione rearrangement enables the synthesis of 2-cyclohexene-1,4-diones from readily available para-quinol substrates. Building on sporadic early reports of this transformation, we have op...

The quinol–enedione rearrangement enables the synthesis of 2-cyclohexene-1,4-diones from readily available para-quinol substrates. Building on sporadic early reports of this transformation, we have optimized the reaction conditions and systematically investigated its substrate scope. The utility of Brønsted acid-mediated reaction conditions for a variety of quinol derivatives, including those with substituted and unsubstituted migrating termini, is highlighted. Notably, kinetic selectivity between quinol–enedione and dienone–phenol rearrangements is demonstrated. The synthetic potential of the enedione products is showcased through a range of transformations, leading to the formation of complex polycyclic structures. These findings provide a valuable framework for recognizing and applying the quinol–enedione rearrangement in synthesis, while computational studies offer valuable insights into its mechanistic underpinnings.

The first total synthesis of the alkaloid brevianamide S has been achieved in eight steps. This natural product, isolated from Aspergillus versicolor, exhibits selective antibacterial activity against...

The School of Chemistry invites applications for a Postdoctoral Research Associate position to work under the supervision of Prof. Andrew Lawrence on a project funded by the Leverhulme Trust. The succ...

PhD Project - Machine Learning-Guided Synthetic Strategies for Natural Product Synthesis at University of Edinburgh, listed on FindAPhD.com

Lecturer in Organic Chemistry - AC2577LS, School of Chemistry Salary: £46,485 - £56,921 per annum (£46,735 - £57,422pa from March 2025) Start Date: August 2025, <p style="text-align: justify;"><span...

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This Feature Article discusses recent advances in the development of cascade ring expansion reactions for the synthesis of medium-sized rings and macrocycles. Cascade ring expansion reactions have muc...