Thomas Julou @thomasjulou.bsky.social · 15/01/2025What does E. coli do when food runs out? We spent years looking at it with our quantitative glasses, and now put the final preprint online: www.biorxiv.org/content/10.1... Congrats to Théo Gervais for the 'tour de force'!biorxiv.org 150
Reposted by Thomas JulouErik van Nimwegen @erikvannimwegen.bsky.social · 15/01/2025What do bacterial cells do when they run out of nutrients? Although most bacterial studies focus on cells in exponentially growing states, in the wild bacteria likely spend most of their time slowly starving to death. 1/n www.biorxiv.org/content/10.1...biorxiv.orgE. coli prepares for starvation by dramatically remodeling its proteome in the first hours after loss of nutrientsIt is widely believed that due to nutrient limitations in natural environments, bacteria spend most of their life in non-growing states. However, very little is known about how bacteria change their p... 213567
Thomas Julou @thomasjulou.bsky.social · 18/12/2024I'm puzzled 🤯 By now, we've spent lots of time measuring the effect of growth rate fluctuations on cell-to-cell variability of GFP concentration using various promoters in E. coli. However, we never observed the negative correlation reported by Patange et al. Now reported by Proenca et al too! 1/n 100
Thomas Julou @thomasjulou.bsky.social · 11/12/2024Still have to read the full article - but from the tweetorial and the figures it sounds so cool 🤩 020
Thomas Julou @thomasjulou.bsky.social · 11/12/2024Switzerland!! 🤩 I lost my train card at a gas station last weekend. Went back after realizing one hour later but couldn't find it... Someone had collected it, and send it back by post, without even writing any sender address. Big big thanks to this anonymous person. 000
Thomas Julou @thomasjulou.bsky.social · 04/12/2024New preprint! doi.org/10.1101/2024... Yet another study where we highlight how noisy gene regulation is in single bacterial cells 🫨 After we measured several promoters regulated by LexA in the mother machine, L. Galbusera and @erikvannimwegen.bsky.social did a great theoretical analysis 1/ndoi.orgTransient transcription factor depletions explain diverse single-cell responses of LexA target promoters to mild DNA damageIn bacteria, the effects of transcription factors (TFs) on the expression of their target genes are highly stochastic at the single-cell level. Not only do TF concentrations fluctuate in time and from... 1127
Thomas Julou @thomasjulou.bsky.social · 02/12/2024Nice!! (link for download: doi.org/10.1016/j.ce...)doi.orgRedirecting 010
