Published: June 10, 2025Updated: June 11, 2025Written by: Beth DoughertyThere are two ways to fix things: the quick way and the careful one. In cancer, cells with BRCA1 mutations tend to choose the quick fix, leaving them vulnerable to medicines like PARP inhibitors.   PARP inhibitors cause DNA to break. When broken strands and sketchy repairs ... Read more

Assistant/Associate Professor, Chemical Biology job

With the recent completion of a multi-agency, state and city regulatory process, the clinical collaboration among Dana-Farber Cancer Institute (Dana-Farber), Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical Faculty Physicians at BIDMC (HMFP) is moving forward. The collaboration will support a new Dana-Farber cancer hospital, and the joint clinical teams are developing comprehensive plans to transform cancer care around the world and push the boundaries of research and innovation.

Ubiquitin-specific protease 7 (USP7) is a deubiquitylase essential for cell homeostasis, DNA repair, and regulation of both tumor suppressors and oncogenes. Inactivating USP7 mutations have been assoc...

Computational design of molecular recognition remains challenging despite advances in deep learning. The design of proteins that bind to small molecules has been particularly difficult because it requ...

YouTube video by Boston Protein Design and Modeling Club

Toure et al. investigate a known challenge in CDK9 inhibition—the compensatory increase in MYC levels. They demonstrate that a selective CDK9 degrader with rapid kinetics circumvents this effect, prov...

C-Terminal cyclic imides are posttranslational modifications on proteins that are recognized and removed by the E3 ligase substrate adapter cereblon (CRBN). Despite the observation of these modificati...

Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses.

TO THE AMERICAN PEOPLE We all rely on science. Science gave us the smartphones in our pockets, the navigation systems in our cars, and life-saving medical care. We count on engineers when we drive acr...