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Jonne Sikkens

@dewittehi.bsky.social
60 followers 210 following 0 posts

Internist acute medicine & infectious diseases, interested in clinical reasoning, General internal medicine, statistics/epidemiology, POCUS, research. Also MSc in clinical epi & neuropsychology

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Reposted by Jonne Sikkens
Michael Friendly @datavisfriendly.bsky.social · 24/04/2025
Would be interesting to run this by an AI agent, as an experiment. Would it choose A or A+B? Could it see any connection with collider bias?
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Eric Topol @erictopol.bsky.social · 24/04/2025
Why you should know your viral exposure status (i.e CMV) if you're going to undergo immunotherapy for cancer (but almost no one knows) www.nature.com/articles/s41...
nature.com
CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade - Nature Medicine
Analysis of multiple cohorts of patients with melanoma demonstrates a positive association between cytomegalovirus serostatus and overall survival in patients treated with monotherapy but not combinat...
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 23/04/2025
The ASIs have arrived www.nejm.org/doi/full/10.... Aldosterone synthase inhibitors - first one to finish the phase 3 line #Lorundrostat #Hypertension
nejm.org
Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension | NEJM
Aldosterone dysregulation contributes to hypertension. Lorundrostat is an aldosterone synthase inhibitor, but data on its efficacy and safety in patients with hypertension are limited. In this mult...
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Dr. Lucky Tran @luckytran.com · 07/04/2025
Do not normalize children dying from measles. Measles was previously eliminated in the US, thanks to vaccines. When children die from measles, it means that adults have catastrophically failed to protect them because they have rejected basic science.
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josh farkas 💊 @pulmcrit.bsky.social · 08/04/2025
a long time ago I used to knock normal saline for being hypertonic I want to set the record straight on this, I was wrong NS & LR are *functionally* isotonic to affect sodium concentration, you'd need to give an impossibly massive volume full discussion here: emcrit.org/ibcc/fluid/#...
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Momen Abbasi @momenabbasi.bsky.social · 30/03/2025
Dropping The Kidney Roast Collection A 90s retro-inspired cartoon project where the kidney finally gets to roast the other organs and specialties — sarcasm, dry humor all packed into vintage medical scenes. 1/4 #ArtCollection #RetroCartoon #MedicalArt #KidneyRoast #Illustration #90sVibe
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Chise @sailorrooscout.bsky.social · 31/03/2025
Lariocidin hits drug-resistant bacteria where others fail- by hijacking the ribosome at a new site, bypassing defenses, and opening the door to a new generation of antibiotics. The study has been published in Nature. YES, it is PEER-REVIEWED. • www.nature.com/articles/s41...
ABSTRACT
Lasso peptides (biologically active molecules with a distinct structurally constrained knotted fold) are natural products that belong to the class of ribosomally synthesized and post-translationally modified peptides.
Lasso peptides act on several bacterial targets but none have been reported to inhibit the ribosome, one of the main targets of antibiotics in the bacterial cell.
Here we report the identification and characterization of the lasso peptide antibiotic lariocidin and its internally cyclized derivative lariocidin B, produced by Paenibacillus sp. M2, which has broad-spectrum activity against a range of bacterial pathogens. We show that lariocidins inhibit bacterial growth by binding to the ribosome and interfering with protein synthesis.
Structural, genetic and biochemical data show that lariocidins bind at a unique site in the small ribosomal subunit, where they interact with the 16S ribosomal RNA and aminoacyl-tRNA, inhibiting translocation and inducing miscoding.
Lariocidin is unaffected by common resistance mechanisms, has a low propensity for generating spontaneous resistance, shows no toxicity to human cells, and has potent in vivo activity in a mouse model of Acinetobacter baumannii infection.
Our identification of ribosome-targeting lasso peptides uncovers new routes towards the discovery of alternative protein-synthesis inhibitors and offers a novel chemical scaffold for the development of much-needed antibacterial drugs.Lariocidin, a lasso-shaped peptide with promising antibiotic properties. (Graphic: Dmitrii Travin and Yury Polikanov). Research: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome.
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Michael Friendly @datavisfriendly.bsky.social · 01/04/2025
I have a short lecture on bootstrapping. friendly.github.io/6135/lecture...
friendly.github.io
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Bits of Freedom @bitsoffreedom.eurosky.social · 10/01/2025
De Nederlandse overheid moet per direct van sociale media platformen van Big Tech-bedrijven af. Dit roepen we samen met @waag.bsky.social, SETUP, PublicSpaces en De Goede Zaak op. www.bitsoffreedom.nl/campagnes/op...
bitsoffreedom.nl
Oproep aan de Nederlandse overheid: vertrek van de sociale media van Big Tech!
Bits of Freedom komt op voor internetvrijheid door de online grondrechten op communicatievrijheid en privacy te beschermen.
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Peter Murphy @peterwmurphy1.bsky.social · 01/01/2025
For Maths fans, 2025 is a square. 45² = 45 x 45 = 2025 Also, 9² x 5² = 2025 40² + 20² + 5² = 2025 My favourite? 1³+2³+3³+4³+5³+6³+7³+8³+9³ = 2025 #Mathematics #teaching #education
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Khoa @khoavuumn.bsky.social · 02/01/2025
Researcher: "We let the data speak for itself." Earlier that day:
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Dr. K. Lotterhos @drk-lo.bsky.social · 22/12/2024
🧪👨‍🔬 #rstats
Guy: "me learning R". Guy whistling at hot girl labeled "Ggplot2 with custom themes". Guy is holding hand with girlfriend labeled "proper data cleaning"
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Edward Nirenberg @enirenberg.bsky.social · 20/12/2024
There's a really interesting new paper out in Science for people who care about immunity to flu (which should be everyone because flu is a VERY big problem): www.science.org/doi/10.1126/... Here's my thread explaining this work🧵
science.org
Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses
The seasonal influenza vaccine contains strains of viruses from distinct subtypes that are grown independently and then combined. However, most individuals exhibit a more robust response to one of the...
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Pausal Zivference @pausalz.bsky.social · 30/12/2024
The n's justify the means
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JAMA @jama.com · 25/12/2024
Among pts hospitalized with AKI, recommendations from a Kidney Action Team did not significantly prevent the composite outcome of worsening AKI stage, dialysis, or mortality, despite a higher rate of recommendation in the intervention group. ja.ma/4iLsIRU
Visual Abstract. Early Diagnosis and Treatment Recommendation Notes in Electronic Health Record for Patients With Acute Kidney Injury
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Josh Davis @gurujosh.bsky.social · 23/12/2024
It's that time of year again. Here are my top 10 ID papers of 2024 1. My opinion 2. Practice changing, paradigm-shifting or dogma challenging 3. Not COVID 4. Alphabetical order by first author 5. CoI for 4 and 5 (I am an author) Summary slide here, details in thread #IDSky #Top10IDpapers
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Casey Parker @broomedocs.bsky.social · 20/12/2024
Can POCUS + Dimer exclude acute aortic dissection in the ED? Or speed up the time to surgery? broomedocs.com/2024/12/prof... #medsky #emimcc #FOAMed @emhighak.bsky.social @pulmcrit.bsky.social @stemlyns.bsky.social
broomedocs.com
PROFUNDUS Trial Review - Broome Docs
The PROFUNDUS trial was published recently in the European Journal of Internal Medicine. THis is my review and critique of the trial. I have tried to
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Matthew Hayek @matthewhayek.bsky.social · 19/12/2024
The field of "ultra-processed" food research & its media coverage are littered with poor definitions & comparisons, w misleading conclusions. This creates an illusion that UPFs provide new insights, but it's all slight-of-hand. @mbolotnikova.bsky.social takes a deep dive www.vox.com/future-perfe...
vox.com
You’re being lied to about “ultra-processed” foods
Coverage of the latest nutrition buzzword is overly broad, arbitrary, and misleading. The problem goes deeper.
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Leon Eyrich Jessen @leonjessen.bsky.social · 18/12/2024
Recommendation: Another great read from David Spiegelhalter www.nature.com/articles/d41...
nature.com
Why probability probably doesn’t exist (but it is useful to act like it does)
All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is.
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Dr. Angelica Lim @petitegeek.bsky.social · 17/12/2024
Other gems from Ted Chiang: I don't call them language models because language is about communicating intent. Since the model does not have any intent, I prefer to call them large text models. #NeurIPS2024
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@IM_Crit_ @imcrit.bsky.social · 17/12/2024
Do you remember this study by Dr Raoult claiming that treatment with hydroxychloroquine reduced virus levels in COVID-19 patients, and that the drug was even more effective if used alongside azithromycin? The study was retracted www.science.org/content/arti...
science.org
Infamous paper that popularized unproven COVID-19 treatment finally retracted
Study on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds
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Chris Klomp @chrisklomp.nl · 16/12/2024
Nieuw verhaal. Je zegt dat je nerveus bent en ik zie je handen trillen als de GGD-arts een infuus aanbrengt in je rechterhand. Als de klok op tien springt, weten we allemaal stilzwijgend dat je allerlaatste uur in is gegaan. Het is goed zo. chrisklomp.nl/het-is-goed-...
chrisklomp.nl
Het is goed zo - Chris Klomp
Het is 09.45 uur op vrijdag 13 december 2024. Op het aanrecht staat je laatste kop en schotel. De resten van een beschuitje en thee. Je zit in je blauwe stoel, een schim van wie je was. Je zegt dat je...
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Katie Wiskar @katiewiskar.bsky.social · 16/12/2024
1/ Time for another #POCUS pitfalls thread: the infamous IVC 🤩 I have MANY thoughts on the IVC 💭 When I first started teaching POCUS, I actually disliked the IVC because it was often poorly done or incorrectly interpreted ❌ I have now come to love the IVC, BUT you have to do it right! #emimcc
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Eric Topol @erictopol.bsky.social · 14/12/2024
A new study this week showed how the most common blood test performed-—the CBC, complete blood count—contains a treasure chest of information that we are missing in reporting out to patients and doctors. erictopol.substack.com/p/your-lab-t...
relationship of complete blood count setpoint metrics to 10-year mortality
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ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 15/12/2024
(it’s a fig tree)
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appliedepi.bsky.social @appliedepi.bsky.social · 11/12/2024
🎄Day 11 🎄: Multi-panel figures! The R package {patchwork} makes professional-looking multi-panel figures like this SUPER easy to do. This means more efficient story telling, saved space, and clearer comparisons between groups. #r #rstats #epi
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Madhu Pai, MD, PhD @madhupai.bsky.social · 05/12/2024
This is spot on
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Christopher Jarvis @christopherjarvis.bsky.social · 05/12/2024
Looks fun here. Okay my fav thing in stats. How do you get an upper bound for a confidence interval when you have no events? 3/n The rule of three. en.m.wikipedia.org/wiki/Rule_of...
en.m.wikipedia.org
Rule of three (statistics) - Wikipedia
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B Grrl @bgrrl.bsky.social · 26/11/2024
Truth #MedSky
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Eric Topol @erictopol.bsky.social · 27/11/2024
The relationship between irregular sleep pattern and major adverse cardiovascular events in over 70,000 UK Biobank participants with accelerometer assessment, not titrated by sleep duration jech.bmj.com/content/earl...
more irregular sleep worse outcomes
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Altmetric @altmetric.com · 18/11/2024
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics
docs.bsky.app
Action Intent Links | Bluesky
Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...
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Journal of Clinical Epidemiology @jclinepi.bsky.social · 27/11/2024
Sorry about the confusion. But there seems to be a glitch in the system. Is now #openaccess, as is the rest of the series!
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Medlife Crisis (Rohin) @medcrisis.bsky.social · 27/11/2024
Medical specialties are named logically Nephros = kidney, -ology = study of Cardiology: kardia = heart But then you come to obstetrics and orthopaedics Obstetric = the one who stands opposite (to catch a projectile neonate) Orthopaedic = straight child (eg fixing club feet/scoliosis etc)
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josh farkas 💊 @pulmcrit.bsky.social · 26/11/2024
Skytorial: Piptazo vs Cefepime 😁 Recently this JAMA-IM paper correlating piptazo with mortality has gained a weird amount of attention (It's been out for months so it's not really new) This one of the most methodologically horrific papers I've ever seen Lets talk real quick about the paper...
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josh farkas 💊 @pulmcrit.bsky.social · 26/11/2024
After I posted that blog, Hamilton et al. published a manuscript on MedRxiv that explains the nitty gritty of what went wrong in the study. JAMA-IM refused to publish their letter to the editor, but you can read it here: (feels like a banned book!) www.medrxiv.org/content/10.1...
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Darren Dahly @statsepi.bsky.social · 26/11/2024
As well as prognostic factors that *aren't* imbalanced! It's amazing. Links to good advice on "how" in the post below.
statsepi.substack.com
Out of balance
A perspective on covariate adjustment in randomized controlled trials in medicine.
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Katie Wiskar @katiewiskar.bsky.social · 26/11/2024
1/ Back to the basics today: let's talk about common pitfalls in obtaining cardiac #POCUS images ❤️ Here are some very common image acquisition errors in basic views, as well as the simple moves to correct them ✅ 🧵 #emimcc #POCUSky #echosky #MedSky
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Gary Collins @gscollins.bsky.social · 26/11/2024
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Matthew Kay @mjskay.com · 26/11/2024
This is a great point, and was one reason @abhsarma.bsky.social (with me + @jessicahullman.bsky.social) built a multiverse analysis tool that tries to help experts understand and evaluate the validity of subsets of a multiverse, rather than just shrugging: "enh, results vary" doi.org/10.1145/3613...
Figure 2: The Milliways interface consists of four panels to support the multiverse analysis tasks and a principled evaluation of the multiverse analysis. The outcome panel Al presents the results of the multiverse-for each universe in the multiverse, we show an outcome or result. The specification panel A2 reveals the options for each parameter which the universe is composed of. The code panel A3 presents the code that was used to construct the multiverse (here, the code was from the multiverse R library). The data panel A4 shows the dataset used in the analysis. Other elements include the add button to add additional outcome variables A5, exclude button to remove options of a parameter AG, link button to link (aggregate) the outcomes across two or more options A7, slider for hierarchical sorting based on average effect AS and the zoom toggle A9Figure 5: Hierarchical sorting based on the average marginal effect allows users to see the variation in the outcome due to the options of a parameter. It also allows users to inspect the outcomes conditional on the options of parametersFigure 6: On aggregation, we represent uncertainty in the result using probability boxesFigure 7: A walkthrough of the steps that Alice performs during her principled evaluation of a multiverse analysis using Milliways which is described in our case study
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Lars Mølgaard Saxhaug @load-dependent.eurosky.social · 26/11/2024
A case of exactly what I mentioned in my last post. When things don’t fit, get better images with better equipment and/or more experienced people involved. #emimcc #cardiosky #echosky #pocus
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