Reposted by Jonne SikkensMichael Friendly @datavisfriendly.bsky.social · 24/04/2025Would be interesting to run this by an AI agent, as an experiment. Would it choose A or A+B? Could it see any connection with collider bias? 121
Reposted by Jonne SikkensEric Topol @erictopol.bsky.social · 24/04/2025Why you should know your viral exposure status (i.e CMV) if you're going to undergo immunotherapy for cancer (but almost no one knows) www.nature.com/articles/s41...nature.comCMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade - Nature MedicineAnalysis of multiple cohorts of patients with melanoma demonstrates a positive association between cytomegalovirus serostatus and overall survival in patients treated with monotherapy but not combinat... 521361
Reposted by Jonne SikkensSwapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 23/04/2025The ASIs have arrived www.nejm.org/doi/full/10.... Aldosterone synthase inhibitors - first one to finish the phase 3 line #Lorundrostat #Hypertensionnejm.orgLorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension | NEJMAldosterone dysregulation contributes to hypertension. Lorundrostat is an aldosterone synthase inhibitor, but data on its efficacy and safety in patients with hypertension are limited. In this mult... 33727
Reposted by Jonne SikkensDr. Lucky Tran @luckytran.com · 07/04/2025Do not normalize children dying from measles. Measles was previously eliminated in the US, thanks to vaccines. When children die from measles, it means that adults have catastrophically failed to protect them because they have rejected basic science. 365242247680
Reposted by Jonne Sikkensjosh farkas 💊 @pulmcrit.bsky.social · 08/04/2025a long time ago I used to knock normal saline for being hypertonic I want to set the record straight on this, I was wrong NS & LR are *functionally* isotonic to affect sodium concentration, you'd need to give an impossibly massive volume full discussion here: emcrit.org/ibcc/fluid/#... 1345
Reposted by Jonne SikkensMomen Abbasi @momenabbasi.bsky.social · 30/03/2025Dropping The Kidney Roast Collection A 90s retro-inspired cartoon project where the kidney finally gets to roast the other organs and specialties — sarcasm, dry humor all packed into vintage medical scenes. 1/4 #ArtCollection #RetroCartoon #MedicalArt #KidneyRoast #Illustration #90sVibe 153
Reposted by Jonne SikkensChise @sailorrooscout.bsky.social · 31/03/2025Lariocidin hits drug-resistant bacteria where others fail- by hijacking the ribosome at a new site, bypassing defenses, and opening the door to a new generation of antibiotics. The study has been published in Nature. YES, it is PEER-REVIEWED. • www.nature.com/articles/s41... 9800167
Reposted by Jonne SikkensMichael Friendly @datavisfriendly.bsky.social · 01/04/2025I have a short lecture on bootstrapping. friendly.github.io/6135/lecture...friendly.github.io 0113
Reposted by Jonne SikkensBits of Freedom @bitsoffreedom.eurosky.social · 10/01/2025De Nederlandse overheid moet per direct van sociale media platformen van Big Tech-bedrijven af. Dit roepen we samen met @waag.bsky.social, SETUP, PublicSpaces en De Goede Zaak op. www.bitsoffreedom.nl/campagnes/op...bitsoffreedom.nlOproep aan de Nederlandse overheid: vertrek van de sociale media van Big Tech!Bits of Freedom komt op voor internetvrijheid door de online grondrechten op communicatievrijheid en privacy te beschermen. 19313125
Reposted by Jonne SikkensPeter Murphy @peterwmurphy1.bsky.social · 01/01/2025For Maths fans, 2025 is a square. 45² = 45 x 45 = 2025 Also, 9² x 5² = 2025 40² + 20² + 5² = 2025 My favourite? 1³+2³+3³+4³+5³+6³+7³+8³+9³ = 2025 #Mathematics #teaching #education 916248194692
Reposted by Jonne SikkensKhoa @khoavuumn.bsky.social · 02/01/2025Researcher: "We let the data speak for itself." Earlier that day: 9679161003
Reposted by Jonne SikkensEdward Nirenberg @enirenberg.bsky.social · 20/12/2024There's a really interesting new paper out in Science for people who care about immunity to flu (which should be everyone because flu is a VERY big problem): www.science.org/doi/10.1126/... Here's my thread explaining this work🧵science.orgCoupling antigens from multiple subtypes of influenza can broaden antibody and T cell responsesThe seasonal influenza vaccine contains strains of viruses from distinct subtypes that are grown independently and then combined. However, most individuals exhibit a more robust response to one of the... 1023670
Reposted by Jonne SikkensPausal Zivference @pausalz.bsky.social · 30/12/2024The n's justify the means 1225
Reposted by Jonne SikkensJAMA @jama.com · 25/12/2024Among pts hospitalized with AKI, recommendations from a Kidney Action Team did not significantly prevent the composite outcome of worsening AKI stage, dialysis, or mortality, despite a higher rate of recommendation in the intervention group. ja.ma/4iLsIRU 1105
Reposted by Jonne SikkensJosh Davis @gurujosh.bsky.social · 23/12/2024It's that time of year again. Here are my top 10 ID papers of 2024 1. My opinion 2. Practice changing, paradigm-shifting or dogma challenging 3. Not COVID 4. Alphabetical order by first author 5. CoI for 4 and 5 (I am an author) Summary slide here, details in thread #IDSky #Top10IDpapers 1110236
Reposted by Jonne SikkensCasey Parker @broomedocs.bsky.social · 20/12/2024Can POCUS + Dimer exclude acute aortic dissection in the ED? Or speed up the time to surgery? broomedocs.com/2024/12/prof... #medsky #emimcc #FOAMed @emhighak.bsky.social @pulmcrit.bsky.social @stemlyns.bsky.socialbroomedocs.comPROFUNDUS Trial Review - Broome DocsThe PROFUNDUS trial was published recently in the European Journal of Internal Medicine. THis is my review and critique of the trial. I have tried to 195
Reposted by Jonne SikkensMatthew Hayek @matthewhayek.bsky.social · 19/12/2024The field of "ultra-processed" food research & its media coverage are littered with poor definitions & comparisons, w misleading conclusions. This creates an illusion that UPFs provide new insights, but it's all slight-of-hand. @mbolotnikova.bsky.social takes a deep dive www.vox.com/future-perfe...vox.comYou’re being lied to about “ultra-processed” foodsCoverage of the latest nutrition buzzword is overly broad, arbitrary, and misleading. The problem goes deeper. 310237
Reposted by Jonne SikkensLeon Eyrich Jessen @leonjessen.bsky.social · 18/12/2024Recommendation: Another great read from David Spiegelhalter www.nature.com/articles/d41...nature.comWhy probability probably doesn’t exist (but it is useful to act like it does)All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is. 031
Reposted by Jonne SikkensDr. Angelica Lim @petitegeek.bsky.social · 17/12/2024Other gems from Ted Chiang: I don't call them language models because language is about communicating intent. Since the model does not have any intent, I prefer to call them large text models. #NeurIPS2024 912023
Reposted by Jonne Sikkens@IM_Crit_ @imcrit.bsky.social · 17/12/2024Do you remember this study by Dr Raoult claiming that treatment with hydroxychloroquine reduced virus levels in COVID-19 patients, and that the drug was even more effective if used alongside azithromycin? The study was retracted www.science.org/content/arti...science.orgInfamous paper that popularized unproven COVID-19 treatment finally retractedStudy on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds 56627
Reposted by Jonne SikkensChris Klomp @chrisklomp.nl · 16/12/2024Nieuw verhaal. Je zegt dat je nerveus bent en ik zie je handen trillen als de GGD-arts een infuus aanbrengt in je rechterhand. Als de klok op tien springt, weten we allemaal stilzwijgend dat je allerlaatste uur in is gegaan. Het is goed zo. chrisklomp.nl/het-is-goed-...chrisklomp.nlHet is goed zo - Chris KlompHet is 09.45 uur op vrijdag 13 december 2024. Op het aanrecht staat je laatste kop en schotel. De resten van een beschuitje en thee. Je zit in je blauwe stoel, een schim van wie je was. Je zegt dat je... 34264039
Reposted by Jonne SikkensKatie Wiskar @katiewiskar.bsky.social · 16/12/20241/ Time for another #POCUS pitfalls thread: the infamous IVC 🤩 I have MANY thoughts on the IVC 💭 When I first started teaching POCUS, I actually disliked the IVC because it was often poorly done or incorrectly interpreted ❌ I have now come to love the IVC, BUT you have to do it right! #emimcc 26230
Reposted by Jonne SikkensEric Topol @erictopol.bsky.social · 14/12/2024A new study this week showed how the most common blood test performed-—the CBC, complete blood count—contains a treasure chest of information that we are missing in reporting out to patients and doctors. erictopol.substack.com/p/your-lab-t... 26545129
Reposted by Jonne Sikkensappliedepi.bsky.social @appliedepi.bsky.social · 11/12/2024🎄Day 11 🎄: Multi-panel figures! The R package {patchwork} makes professional-looking multi-panel figures like this SUPER easy to do. This means more efficient story telling, saved space, and clearer comparisons between groups. #r #rstats #epi 12911
Reposted by Jonne SikkensChristopher Jarvis @christopherjarvis.bsky.social · 05/12/2024Looks fun here. Okay my fav thing in stats. How do you get an upper bound for a confidence interval when you have no events? 3/n The rule of three. en.m.wikipedia.org/wiki/Rule_of...en.m.wikipedia.orgRule of three (statistics) - Wikipedia 03013
Reposted by Jonne SikkensEric Topol @erictopol.bsky.social · 27/11/2024The relationship between irregular sleep pattern and major adverse cardiovascular events in over 70,000 UK Biobank participants with accelerometer assessment, not titrated by sleep duration jech.bmj.com/content/earl... 419147
Reposted by Jonne SikkensAltmetric @altmetric.com · 18/11/2024We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetricsdocs.bsky.appAction Intent Links | BlueskyAuthors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu... 166113164572
Reposted by Jonne SikkensJournal of Clinical Epidemiology @jclinepi.bsky.social · 27/11/2024Sorry about the confusion. But there seems to be a glitch in the system. Is now #openaccess, as is the rest of the series! 161
Reposted by Jonne SikkensMedlife Crisis (Rohin) @medcrisis.bsky.social · 27/11/2024Medical specialties are named logically Nephros = kidney, -ology = study of Cardiology: kardia = heart But then you come to obstetrics and orthopaedics Obstetric = the one who stands opposite (to catch a projectile neonate) Orthopaedic = straight child (eg fixing club feet/scoliosis etc) 9684
Reposted by Jonne Sikkensjosh farkas 💊 @pulmcrit.bsky.social · 26/11/2024Skytorial: Piptazo vs Cefepime 😁 Recently this JAMA-IM paper correlating piptazo with mortality has gained a weird amount of attention (It's been out for months so it's not really new) This one of the most methodologically horrific papers I've ever seen Lets talk real quick about the paper... 56025
Reposted by Jonne Sikkensjosh farkas 💊 @pulmcrit.bsky.social · 26/11/2024After I posted that blog, Hamilton et al. published a manuscript on MedRxiv that explains the nitty gritty of what went wrong in the study. JAMA-IM refused to publish their letter to the editor, but you can read it here: (feels like a banned book!) www.medrxiv.org/content/10.1... 1182
Reposted by Jonne SikkensDarren Dahly @statsepi.bsky.social · 26/11/2024As well as prognostic factors that *aren't* imbalanced! It's amazing. Links to good advice on "how" in the post below.statsepi.substack.comOut of balanceA perspective on covariate adjustment in randomized controlled trials in medicine. 1217
Reposted by Jonne SikkensKatie Wiskar @katiewiskar.bsky.social · 26/11/20241/ Back to the basics today: let's talk about common pitfalls in obtaining cardiac #POCUS images ❤️ Here are some very common image acquisition errors in basic views, as well as the simple moves to correct them ✅ 🧵 #emimcc #POCUSky #echosky #MedSky 811254
Reposted by Jonne SikkensMatthew Kay @mjskay.com · 26/11/2024This is a great point, and was one reason @abhsarma.bsky.social (with me + @jessicahullman.bsky.social) built a multiverse analysis tool that tries to help experts understand and evaluate the validity of subsets of a multiverse, rather than just shrugging: "enh, results vary" doi.org/10.1145/3613... 58430
Reposted by Jonne SikkensLars Mølgaard Saxhaug @load-dependent.eurosky.social · 26/11/2024A case of exactly what I mentioned in my last post. When things don’t fit, get better images with better equipment and/or more experienced people involved. #emimcc #cardiosky #echosky #pocus 3247