Cells and tissue integrity are constantly challenged by the necessity to adapt and respond to mechanical loads. Among cellular components, the nucleus possesses mechano-sensing and mechanotransduction...

Different proteins activate the cell-cycle kinase Plk1 at distinct stages of the cell cycle. Here, Dwivedi et al. show how the different activators control Plk1 to coordinate DNA replication, mitotic ...

Nature Protocols, Published online: 25 July 2025; doi:10.1038/s41596-025-01211-2This is a protocol for the large-scale expansion of proliferating human hepatocytes derived from human donor livers. These can be rematured in a three-dimensional culture system and are amenable to genetic manipulation.

The red fluorescent protein mScarlet3-H is bright, photostable and very robust to high temperature, chaotropic conditions and oxidative environments. mScarlet3-H works well in correlative light and el...

Delivery of autoimmune disease–associated antibodies activates the immune system to fight glioblastomas.

A gene-edited pig liver transplanted into a human recipient remains functional after 10 days and indicates that porcine organs could help meet the growing demand for liver transplants.