iiinova — where your digital self keeps evolving

Reposted by Dennis Frank

Robert Grosse @ grosselab @grosselab.bsky.social · 19/03/2026

and check out the animation in the supplement that Hong did (download only) !

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Reposted by Dennis Frank

Robert Grosse @ grosselab @grosselab.bsky.social · 17/11/2025

It was inspiring and fun hosting Patrick Lusk @luskinglab.bsky.social as our seminar guest, here looking at cell nuclei and peppers with AFM expert Dennis @denfra.bsky.social

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Reposted by Dennis Frank

Robert Grosse @ grosselab @grosselab.bsky.social · 22/10/2025

Svenja Ulferts @sulferts.bsky.social receiving a wonderful doctoral thesis award from our @uni-freiburg.de president 🥳🍾 - well done and well deserved!

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Reposted by Dennis Frank

Robert Grosse @ grosselab @grosselab.bsky.social · 22/09/2025

we found that nuclear envelope rupture triggers rapid DIAPH3 formin influx to generate a actin mesh to prevent further chromatin leakage from damaged nuclei. thanks to Pitter Huesgen @degradomics.bsky.social and @cibss.bsky.social, @chrkam.bsky.social

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Reposted by Dennis Frank

The EMBO Journal @embojournal.org · 22/09/2025

Nuclear rupture in confined cell migration triggers nuclear actin polymerization to limit chromatin leakage DDR sensor ATR protects against nuclear envelope rupture via formin phosphorylation inducing F-actin formation Christos Kamaras et al @grosselab.bsky.social www.embopress.org/doi/full/10....

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Reposted by Dennis Frank

Robert Grosse @ grosselab @grosselab.bsky.social · 31/07/2025

Hi all, check out our new preprint where we uncover:"Regulation of YAP activity by nuclear G-actin binding", www.biorxiv.org/cgi/content/... #actin #YAP/TAZ #transcription #nucleus with help from Sonja-Verena Albers ‪@archaellum.bsky.social‬

biorxiv.org

Regulation of YAP activity by nuclear G-actin binding

The Yes-associated protein YAP belongs to the TEAD (TEA/ATTS domain) transcriptional co-activators that shuttle between cytoplasm and nuclear compartment. YAP and its paralog TAZ (transcriptional co-a...

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