bdyxwh.bsky.social @bdyxwh.bsky.social · 19/03/2026Excited to share our new findings: nuclear G-actin directly binds YAP and forms the YAP-TEAD complex to drive transcription. New role of actin in Hippo signalling! @narjournal.bsky.social 031
Reposted by @bdyxwh.bsky.socialRobert Grosse @ grosselab @grosselab.bsky.social · 19/03/2026Hong's @bdyxwh.bsky.social paper is out with help from @sshamphavi.bsky.social and @archaellum.bsky.social. We discovered a link between nuclear actin and YAP/TAZ: G-actin forms a complex with YAP-TEAD for transcription. academic.oup.com/nar/article/...academic.oup.comRegulation of YAP activity by nuclear G-actin bindingAbstract. The Yes-associated protein YAP belongs to the TEAD (TEA/ATTS domain) transcriptional co-activators that shuttle between the cytoplasm and the nuc 22514
Reposted by @bdyxwh.bsky.socialpengbo10.bsky.social @pengbo10.bsky.social · 09/03/2026What a beautiful journey! Huge thanks to all the amazing collaborators who made this work possible. 032
Reposted by @bdyxwh.bsky.socialChristophe Le Clainche @actin-paris-saclay.bsky.social · 02/01/2026New paper out! We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution. Huge congrats to Aurélie Favarin, Rayan Said, & all authors! In Science Advances: www.science.org/doi/10.1126/... #actin #myosin #mechanobiology 36827
Reposted by @bdyxwh.bsky.socialChris Toseland @christoseland.bsky.social · 14/11/2025We are very happy to share our new PrePrint: Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells. www.biorxiv.org/content/10.1... We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality. 12210
Reposted by @bdyxwh.bsky.socialRobert Grosse @ grosselab @grosselab.bsky.social · 14/11/2025how cool is that? Congrats!! 141
Reposted by @bdyxwh.bsky.socialRobert Grosse @ grosselab @grosselab.bsky.social · 22/09/2025we found that nuclear envelope rupture triggers rapid DIAPH3 formin influx to generate a actin mesh to prevent further chromatin leakage from damaged nuclei. thanks to Pitter Huesgen @degradomics.bsky.social and @cibss.bsky.social, @chrkam.bsky.social 05215
Reposted by @bdyxwh.bsky.socialRobert Grosse @ grosselab @grosselab.bsky.social · 31/07/2025Hi all, check out our new preprint where we uncover:"Regulation of YAP activity by nuclear G-actin binding", www.biorxiv.org/cgi/content/... #actin #YAP/TAZ #transcription #nucleus with help from Sonja-Verena Albers @archaellum.bsky.socialbiorxiv.orgRegulation of YAP activity by nuclear G-actin bindingThe Yes-associated protein YAP belongs to the TEAD (TEA/ATTS domain) transcriptional co-activators that shuttle between cytoplasm and nuclear compartment. YAP and its paralog TAZ (transcriptional co-a... 32518
Reposted by @bdyxwh.bsky.socialRobert Grosse @ grosselab @grosselab.bsky.social · 27/06/2025from our 'older' paper Baarlink et al. 2017, live imaging of a dividing mouse fibroblast stably expressing a shuttling chromobody detecting actin - showing nuclear actin filaments during postmitotic nuclear expansion and chromatin decompaction as well as simultaneous membrane dynamics 051
Reposted by @bdyxwh.bsky.socialRobert Grosse @ grosselab @grosselab.bsky.social · 06/03/2025please re-post! we are looking for a PhD candidate: www.uniklinik-freiburg.de/en/career/jo... 028
Reposted by @bdyxwh.bsky.socialChristophe Le Clainche @actin-paris-saclay.bsky.social · 10/11/2024Very pleased to share the publication of our paper "Talin and vinculin combine their activities to trigger actin assembly" in Nature Commun. Congratulations Hong Wang for your great work ! Thanks to our team members, and the Grosse team. Article here: www.nature.com/articles/s41... 1187
