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David Zappulla

@dczapp.bsky.social
123 followers 187 following 7 posts

Biomedical researcher & professor studying telomerase RNP, telomeres, lncRNAs, & senescence. Opinions are my own, not necessarily those of my employer. (He/him)

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Reposted by David Zappulla
The New York Times @nytimes.com · 21/02/2026
From @theathletic.com: Johannes Høsflot Klæbo of Norway on Saturday won his sixth gold medal, the most by any athlete at a single Winter Olympic Games.
nytimes.com
Johannes Høsflot Klæbo wins sixth gold, most ever in a single Winter Olympics
Klaebo became the winningest athlete at a single Winter Olympics, sweeping the men's cross-country golds in Italy.
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EMBO @embo.org · 09/02/2026
Deadline tomorrow! Explore advances in telomere biology and its involvement in homeostasis and disease in EMBO Workshop "Telomere function and maintenance in health and disease" in Lazise, IT, 25–30 May 2026. meetings.embo.org/event/26-telomere #EMBOTelomereMaintenance #EMBOevents 🧪
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phy_papers @phypapers.bsky.social · 25/02/2025
S. pombe telomerase RNA: secondary structure and flexible-scaffold function www.biorxiv.org/content/10.1101/202…
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David Zappulla @dczapp.bsky.social · 30/11/2025
We have now published our secondary-structure model for the 1212 nt 𝘚. 𝘱𝘰𝘮𝘣𝘦 telomerase RNA, derived largely from bioinformatic and phylogenetic analyses of genomic data. (1/2) www.tandfonline.com/doi/full/10....
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David Zappulla @dczapp.bsky.social · 02/06/2025
“Put another way, punishing campuses by cutting health research funding would destroy the equivalent of one-quarter of annual gross domestic product in the US.”
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Jeremy Berg @jeremymberg.bsky.social · 02/06/2025
JAMA Forum on the proposed NIH budget… jamanetwork.com/journals/jam...
jamanetwork.com
Cutting the NIH—The $8 Trillion Health Care Catastrophe
This JAMA Forum discusses the recent budget cuts to National Institutes of Health (NIH), the effects of these cuts on scientific research and health of individuals in the US, and the prospects for cha...
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Eric Topol @erictopol.bsky.social · 31/05/2025
"If the proposal is enacted, Americans today and tomorrow will be sicker, poorer, and die younger” an $18 Billion cut Only 3 NIH Institutes will remain in place, and even they will have their funds markedly reduced www.statnews.com/2025/05/30/n...
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Eric Topol @erictopol.bsky.social · 27/05/2025
A new cover for SUPER AGERS after making the NYT bestseller list. Thanks to you for making it the #1 ranked new non-fiction book on Amazon. amazon.com/gp/new-relea...
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The New York Times @nytimes.com · 22/05/2025
In St. Louis, the sirens to warn people of a tornado threat were not activated by the City Emergency Management Agency before a deadly tornado hit on Friday, and a backup to activate the mechanism that is operated by the Fire Department was broken.
nytimes.com
Warning Sirens Were Silent Ahead of Deadly Tornado in St. Louis, City Says
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Scott Delaney @scott-delaney.bsky.social · 16/05/2025
More context: Our tracker (grant-watch.us) currently lists 877 terminated NIH grants. We have 820 rows in the tracker, but some rows list multiple grants. As of yesterday, NIH RePORTER listed 807 NIH grants specifically at Harvard. So we're looking at over 1600 formally terminated NIH grants now.
grant-watch.us
Grant Watch
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Wolf Conservation Center 🐺 @nywolforg.bsky.social · 28/04/2025
The USFWS has announced that it killed the breeding male of the Hail Canyon pack in New Mexico. The wolf, a 5 yr old dad named Viento, was the breeding male of a family of wolves that includes Slides - the Mexican gray wolf fostered from the WCC into the wild in 2023.
nywolf.org
Government Kills Another Endangered Mexican Wolf at the Behest of the Livestock Industry
Just days after admitting that it killed the wrong Mexican wolf in Arizona, the U.S. Fish and Wildlife Service has announced that it also killed the breeding male of the Hail Canyon pack in New Mexico...
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Eric Topol @erictopol.bsky.social · 12/04/2025
Measles in the US, update —712 cases, 11% hospitalized, 3 deaths, 97% cases are unvaccinated —Now in 24 states —Actual cases must be multiple thousand to align with the number of hospitalizations and deaths reported www.cdc.gov/measles/data... www.cbsnews.com/news/measles...
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Saccharomyces Genome Database @yeastgenome.bsky.social · 02/04/2025
Application deadline extended to Apr 15 for this summer's #Yeast #Genetics & #Genomics course at @cshlaboratory.bsky.social July22 - Aug12! Get a comprehensive education in all things yeast, from classical genetics through up-to-the-minute genomics. Don't miss out! meetings.cshl.edu/courses.aspx...
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Saccharomyces Genome Database @yeastgenome.bsky.social · 20/03/2025
The Pacific Northwest Yeast Club is holding their annual meeting on June 20th, 2025 in beautiful Vancouver, Canada! There are only 100 spots and registration is open now: www.pnwyc.net
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 08/04/2025
This!!! I hope someone in Washington is listening www.wsj.com/tech/biotech...
wsj.com
China’s Biotech Advances Threaten U.S. Dominance, Warns Congressional Report
Congress should invest at least $15 billion to support biotech research over the next five years and take other steps to bolster manufacturing in the U.S., the report said.
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Jeremy Berg @jeremymberg.bsky.social · 08/04/2025
Looking at grant funding time for all years from 2015-2025 Here is the graph for new and competitive renewal grants (dollar amounts normalized by the overall NIH grant budget for each year_ 1/2
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Denis Wirtz @deniswirtz.bsky.social · 02/04/2025
I don’t think the country understands the nuclear bomb that has hit and destroyed Americas future. Our competitiveness globally was threatened - it is now guaranteed to dwindle to irrelevance. The future is based on science and technology. By the time they realize the damage, it will be too late. AR
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Wolf Conservation Center 🐺 @nywolforg.bsky.social · 31/03/2025
Tragic, infuriating news. Mexican gray wolf Ella, whose travels captivated a nation just last week, was found dead in New Mexico. The U.S. Fish and Wildlife Service has indicated that the cause of Ella’s death is under investigation.
nywolf.org
Wandering Wolf “Ella” Found Deceased in New Mexico
The Mexican gray wolf who just last week was located north of Interstate 40 near Mount Taylor in New Mexico was found dead on Sunday, March 30, 2025. The U.S. Fish and Wildlife Service has indicated t...
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Ryan Comes @rbcomes.bsky.social · 30/03/2025
🧪⚛️ If you want to sign a petition to protect the NIST Atomic Spectroscopy Group, here's an opportunity: www.change.org/p/oppose-the... Hat tip to @nanoscaleviews.bsky.social for sharing this.
change.org
Sign the Petition
Oppose the layoff of the NIST Atomic Spectroscopy Group
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Larry Hunter @proflhunter.bsky.social · 31/03/2025
The destruction of American science continues apace. Early career people are the most likely to be seeking to leave. One of my about-to-graduate PhDs is seriously considering a job offer in Germany, even though it would involve lower pay. www.nature.com/articles/d41...
nature.com
75% of US scientists who answered Nature poll consider leaving
More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.
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Mark Cuban @mcuban.bsky.social · 22/03/2025
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
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Eric Topol @erictopol.bsky.social · 22/03/2025
I've reviewed 10 consumer-facing companies that are in the business of promoting longevity and healthspan erictopol.substack.com/p/the-busine... Open-access, in the new edition of Ground Truths
Table of 10 companies selling longevity and extended healthspan
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Eric Topol @erictopol.bsky.social · 21/03/2025
Texas measles update today 309 cases; 40 have been hospitalized (<-which means there are far more than 300 cases diagnosed) www.dshs.texas.gov/news-alerts/...
dshs.texas.gov
Measles Outbreak – March 21, 2025 | Texas DSHS
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Jeremy Berg @jeremymberg.bsky.social · 21/03/2025
ATTENTION If you are someone (or know someone) who is enrolled in an NIH-funded clinical trial that has been disrupted by grant uncertainties or terminations, please DM me. THANK YOU!
media.tenor.com
stan marsh from south park says see that 's what happened to me !
ALT: stan marsh from south park says see that 's what happened to me !
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Alliance of Genome Resources @alliancegenome.bsky.social · 19/03/2025
New SGD paper! Saccharomyces Genome Database: advances in genome annotation, expanded biochemical pathways, and other key enhancements academic.oup.com/genetics/art...
academic.oup.com
Saccharomyces Genome Database: advances in genome annotation, expanded biochemical pathways, and other key enhancements
Abstract. Budding yeast (Saccharomyces cerevisiae) is the most extensively characterized eukaryotic model organism and has long been used to gain insight i
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Science Friday @scifri.bsky.social · 16/03/2025
90% of people diagnosed with pancreatic cancer die from the disease. That's why the medical community is excited about the results of a small trial in which nearly half of the pancreatic cancer patients who received an mRNA vaccine for the disease remained relapse-free three years later.
sciencefriday.com
A Vaccine For Pancreatic Cancer Continues To Show Promise
In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine for the disease had no relapse three years later.
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Chise @sailorrooscout.bsky.social · 15/03/2025
THIS IS INCREDIBLE! Cohen Children’s Medical Center has confirmed that it has successfully ELIMINATED sickle cell disease from Sebastien Beauzile, using the groundbreaking genetic treatment Lyfgenia. He has made HISTORY by becoming the FIRST in New York to be CURED of sickle cell anemia! 🧪🧵⬇️
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Jeremy Berg @jeremymberg.bsky.social · 08/03/2025
We have a winner...
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Amber “Dino Lady” Redfield @palaeoamber.com · 07/03/2025
Stand Up For Science 2025 in Philadelphia Pennsylvania
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Sarah McAnulty, Ph.D. @sarahmackattack.bsky.social · 06/03/2025
Hey Philly people, come to the Stand Up For Science rally tomorrow at City Hall! I'll be speaking around noon! There are rallies all over the country, you can find your local rally here standupforscience2025.org/local-event-...
A blue background and red and white works say: Philadelphia how will you stand up for science march 7 2025, 11am city hall
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Fred Hutch @fredhutch.org · 03/03/2025
Fred Hutch researchers discover that overproduction of DNA packaging material predicts aggressive brain and breast tumors, which could lead to cheaper diagnostic tests and new drug therapies. bit.ly/43kHcCV
bit.ly
New methods reveal cancer mechanism in ancient genes
Researchers at Fred Hutch Cancer Center have discovered an overlooked mechanism driving aggressive breast and brain tumors involving genes so ancient — more than 2 billion years old — that they fly un...
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Eric Topol @erictopol.bsky.social · 03/03/2025
A rapid CRISPR test could completely transform the diagnosis of Pneumocystis pneumonia, a life-threatening fungal infection. Today it typically requires invasive bronchoscopy, but this test enables rapid detection from blood or throat swabs. www.jci.org/articles/vie...
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David Zappulla @dczapp.bsky.social · 23/02/2025
In a preprint published today, we are excited to report the secondary structure of the 1212 nt fission-yeast S. pombe telomerase RNA, TER1, and its roles in the physicofunctional organization of this massive, flexible enzymatic RNP complex. www.biorxiv.org/content/10.1...
The 1212 nt fission-yeast S. pombe telomerase RNA (TER1) secondary structure, determined by phylogenetics and bioinformatics
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The New York Times @nytimes.com · 13/02/2025
A worsening measles outbreak has taken root in Texas, sickening two dozen and hospitalizing nine on the western edge of the state, where childhood vaccination rates have dwindled in recent years.
nytimes.com
Measles Outbreak Hits Town in Texas
As of Tuesday, 22 children and two adults had been infected, all of whom were unvaccinated, local officials said.
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Katie Phang @katiephang.bsky.social · 11/02/2025
JUST IN: Federal judges orders HHS, CDC, and FDA to restore “by no later than 11:59 pm” today their websites and datasets to pre-January 30th status. storage.courtlistener.com/recap/gov.us...
storage.courtlistener.com
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Chise @sailorrooscout.bsky.social · 01/02/2025
AMAZING! A GROUNDBREAKING sickle cell disease treatment has been APPROVED for NHS use. Exagamglogene (exa-cel) SUCCESSFULLY edits the faulty gene in a patient’s OWN stem cells. Researchers concluded there was a functional cure in 97% of trial participants that received it! Let’s talk about that! 🧪🧵⬇️
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Dr. Lucky Tran @luckytran.com · 23/01/2025
The Trump admin has cancelled the panels that approve NIH grants, & is also banning scientists from communicating with the public, attending conferences, and hiring. NIH is the largest funder of biomedical research in the world. This will severely halt the development of many lifesaving treatments.
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Eric Topol @erictopol.bsky.social · 16/01/2025
98% of microplastic particles (MP) in bottled water are smaller than 20 μm, which are much more likely to get thru the GI tract to blood and organ tissue. Municipal tap water was higher in MP than 8 of 10 bottled water brands journals.plos.org/water/articl...
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CNN @cnn.com · 11/01/2025
An international research team has successfully drilled and retrieved a 9,186-foot-long (2,800-meter-long) ice core from Antarctica that dates back 1.2 million years. The sample extended so deep that it reached the bedrock beneath the Antarctic Ice Sheet. Read more: cnn.it/3Wekfgo
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The New York Times @nytimes.com · 25/12/2024
Twenty big cats, including a half-Bengal tiger and four cougars, died at a sanctuary in Washington State after becoming infected with bird flu, according to the facility’s director. “We’ve never had anything like it.”
nytimes.com
20 Big Cats Die From Bird Flu at a Washington Sanctuary
More than half of the cats at the sanctuary in Shelton, Wash., died of the virus over the past several weeks.
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Chenshu Liu @chenshuliu.bsky.social · 12/12/2024
🚨The deadline to apply for Lehigh University’s Biological Sciences PhD program is just a few weeks away! Are you (or do you know) an amazing undergrad, post-bac, or master’s student passionate about science & ready to thrive in a supportive, interdisciplinary environment? Apply here!👉bit.ly/3VwZL29
Flyer for the Biological Sciences PhD Program at Lehigh University, with images highlighting the diverse research being carried out in this program. Application deadline Jan 1st, 2025.
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Chenshu Liu @chenshuliu.bsky.social · 22/11/2024
🚀 Excited to share that my postdoc work with @adernburg.bsky.social on a Piezo-dependent meiotic checkpoint in C. elegans has just been published in Science doi.org/10.1126/scie... Here's a summary thread, or a “Skydive” (coined by @harmitmalik.bsky.social‬), of the key findings in this work 🧵⬇️1/10
doi.org
Chemically induced proximity reveals a Piezo-dependent meiotic checkpoint at the oocyte nuclear envelope
Sexual reproduction relies on robust quality control during meiosis. Assembly of the synaptonemal complex between homologous chromosomes (synapsis) regulates meiotic recombination and is crucial for a...
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The New York Times @nytimes.com · 07/12/2024
The world’s oldest known wild bird, a 74-year-old Laysan albatross named Wisdom, is expected to welcome another baby chick in the coming months, astonishing scientists who have been tracking her since the Eisenhower administration. nyti.ms/4f7VadN
A photo of Wisdom, a 74-year-old Laysan albatross, looking at an egg at Midway Atoll National Wildlife Refuge at the northwestern edge of the Hawaiian Archipelago. Headline reads: "World’s Oldest Known Wild Bird Lays an Egg at 74." Photo credit: Dan Rapp/U.S. Fish and Wildlife Service via Associated Press.
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The New York Times @nytimes.com · 17/11/2024
One person has died and 39 people have become ill in an E. coli outbreak linked to organic carrots, federal regulators said on Sunday.
nytimes.com
E. Coli Outbreak Linked to Organic Carrots
One person has died and nearly 40 people have been sickened in an E. coli outbreak tied to multiple brands of recalled organic carrots sold by Grimmway Farms, officials said.
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