Reposted by David Huang
Our paper on CALM vaccination is out: late liver-stage inhibition of plasmepsin IX/X induces long‑lived sterile protection. Thanks to wonderful coauthors & funders for making this possible. @wehi-research.bsky.social @mercksharpanddohme.bsky.social #Malaria #Vaccines www.science.org/doi/10.1126/...
science.org
Chemovaccination with a late-liver-stage antimalarial induces durable immunity against malaria
Plasmodium falciparum sporozoite vaccines, in which parasites are attenuated at the liver stage, provide high efficacy but require complex manufacture and intravenous administration of high sporozoite...