iiinova — where your digital self keeps evolving

Daniel Irimia @daniel-irimia.bsky.social · 14/01/2026

This comprehensive analysis appears to ignore the neutrophils. While neutrophils represent more than half of the white blood cells, should one assume that they do not contribute to the 19 inflammatory diseases?

100

Reposted by Daniel Irimia

Erinke van Grinsven @erinkevg.bsky.social · 14/11/2025

It has been a real pleasure to dive deep into the wonderful world of the unique and peculiar shape of the neutrophil nucleus, together with Ananda and Irina in the @udalovalab.bsky.social, and I'm proud this literature review is now out in @natrevimmunol.nature.com. rdcu.be/ePKFk

0143

Reposted by Daniel Irimia

Long Covid Advocacy @longcovidadvoc.com · 17/11/2025

Researchers compared blood from Long Covid patients with healthy controls, focusing on two features: microclots and NETs (neutrophil extracellular traps). 2/ www.independent.co.uk/news/science...

independent.co.uk

Long Covid has done something strange to people’s blood

Tiny clots appeared larger-than-normal in long Covid patients, study finds

1177

Reposted by Daniel Irimia

Journal of Cell Biology @jcb.org · 19/11/2025

Wang, Kim, Ding et al. of the Qing Deng lab demonstrate that inward-rectifying potassium channels maintain the resting membrane potential and are required for directional sensing during #neutrophil chemotaxis. rupress.org/jcb/article/...

044

Reposted by Daniel Irimia

Journal of Cell Biology @jcb.org · 26/11/2025

Inwardly rectifying potassium channels promote directional sensing during #neutrophil chemotaxis, say Tianqi Wang, Daniel Kim, Chang Ding, GuangJun Zhang, Qing Deng, and colleagues (Purdue University) rupress.org/jcb/article/... #Migration #motility #Immunology

042

Reposted by Daniel Irimia

ME/CFS Science @mecfsscience.org · 21/10/2025

1) Dr. Vanessa Velasco gave preliminary results on OMF's new neutrophil study. She found that neutrophils of ME/CFS patients died quicker and more often than those of healthy controls, under inflammatory conditions.

22110

Daniel Irimia @daniel-irimia.bsky.social · 29/10/2025

Qualitative and Quantitative Analysis of Circulating NET-derived chromatin and nucleosomes in... - goo.gl/scholar/MJk5Y4 #ScholarAlerts

goo.gl

000

Reposted by Daniel Irimia

NEJM.org @nejm.org · 18/10/2025

A 52-year-old man with a history of splenectomy and hypogammaglobulinemia after CAR T-cell therapy for lymphoma 3 years earlier was admitted with septic shock. Encapsulated diplococci were seen in 20% of neutrophils. Read the full case details: nej.md/4oap9GL #MedSky #IDSky

Images in Clinical Medicine
Pneumococcal Sepsis in a Patient with Asplenia and Hypogammaglobulinemia

Panel A: Encapsulated diplococci seen in 20% of neutrophils on a peripheral-blood smear.
Panels B and C: Multiorgan dysfunction and purpura fulminans of the nose and fingers developed.

093

Reposted by Daniel Irimia

Nader Ghasemlou @ghasemloulab.bsky.social · 02/10/2025

We've published our very first clinical study where we found that chronic low back pain rhythmicity contributes to biopsychosocial outcomes, including opioid use, via the neutrophil degranulation pathway t.co/0yFdJemScW

153

Reposted by Daniel Irimia

Journal of Clinical Investigation @jci.org · 01/10/2025

This issue’s cover art represents the potential for improving pain relief by restoring circadian rhythmicity @ghasemloulab.bsky.social & team link daily pain rhythmicity with neutrophil activation, better biopsychosocial profiles, & reduced opioid use: buff.ly/GR3SOAK

041

Reposted by Daniel Irimia

Blood Journals Portfolio @bloodjournals.hematology.org · 02/10/2025

New Blood issue out featuring: The acute myeloid leukemia microenvironment impairs neutrophil maturation and function through NF-κB signaling buff.ly/0vhlcDl

053

Reposted by Daniel Irimia

NEJM.org @nejm.org · 04/07/2025

𝐏𝐡𝐚𝐠𝐨𝐜𝐲𝐭𝐨𝐬𝐢𝐬 is the process by which a phagocyte (a type of white cell such as macrophage, monocyte, or neutrophil) engulfs large particles, usually pathogens or debris from dead or dying cells, and removes them from the bloodstream. #MedSky #ScienceSky

A visual representation of "phagocytosis"

2223

Reposted by Daniel Irimia

Amber Stratman @astratman.bsky.social · 15/07/2025

Excited to be involved with this work driven by @dremilygoldberg.bsky.social and her team! Read the preprint now! "Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth"

195

Reposted by Daniel Irimia

NEJM.org @nejm.org · 04/07/2025

To learn more about this NEJM Illustrated Glossary term, read the editorial “Defanging the Neutrophil to Treat Bronchiectasis” by Adam T. Hill, MD: nej.md/4cANv89  Explore more terms: nej.md/glossary

031

Reposted by Daniel Irimia

Alejandro Brenes @ajbrenes.com · 27/07/2025

This is a technical feat showing the progress in sample processing an instrument sensitivity, as we estimate we inject 30pg of protein content from a single neutrophil. Yet we can detect >3,000 proteins from 500 neutrophils and >1,100 from a single GBM associated neutrophil!

141

Daniel Irimia @daniel-irimia.bsky.social · 13/08/2025

While this inhibitor also reduces the potency of neutrophils against infections, it remains to be seen how much the risk for fungal and bacterial infections increases in the treated patients.

000

Daniel Irimia @daniel-irimia.bsky.social · 13/08/2025

DPP1 cleaves the inactive proenzymes of neutrophil elastase (NE), proteinase 3 (PR3), and cathepsin G (CatG) in neutrophil precursor cells during their development in the bone marrow. In bronchiectasis (NCFB), the inhibition of DPP1 may reduce neutrophil-driven inflammation and avoid lung damage.

100

Daniel Irimia @daniel-irimia.bsky.social · 13/08/2025

A new drug acting on neutrophils is FDA cleared - an event in that not many neutrophil-acting drugs are out there! This is an inhibitor of DPP1... read more insmed.com

insmed.com

Insmed | For us, everything starts with people.

We work hard to understand the experiences of those living with serious diseases as we strive to deliver true change.

110