Christy Niemeyer, PhD @csniemeyerphd.bsky.social · 02/05/2025My new article on @sciencerabbit.bsky.social discussing why women make up 2/3 of all Alzheimer’s disease patients. 010
Christy Niemeyer, PhD @csniemeyerphd.bsky.social · 11/03/2025Today’s STEM Day at the capital was a success! My students worked so hard on making posters that were accessible and highlighted all the important work we are doing! @projbridgeco.bsky.social @cuanschutz.bsky.social 052
Christy Niemeyer, PhD @csniemeyerphd.bsky.social · 08/03/2025Check out this article on @sciencerabbit.bsky.social giving a deep dive into The Link Between Shingles and Stroke sciencerabbit.org/2025/02/20/s...sciencerabbit.orgThe Link Between Shingles and Stroke ExplainedProf. Andrew Bubak (PhD, MS) - The varicella zoster virus (VZV), primarily known for causing chickenpox and shingles, can reactivate and significantly increase stroke risk. Studies indicate a heighten... 020
Reposted by Christy Niemeyer, PhDNature Microbiology @natmicrobiol.nature.com · 03/02/2025OUT NOW: Human enteric α-defensin 5 interacts with colonic epithelial receptor P2Y11 to induce filopodia and promote Shigella infection by Kai Ye & co www.nature.com/articles/s41...nature.comShigella infection is facilitated by interaction of human enteric α-defensin 5 with colonic epithelial receptor P2Y11 - Nature MicrobiologyHD5 induces filopodial extensions in epithelial cells that the pathogen Shigella exploits to facilitate invasion and infection. 085
Reposted by Christy Niemeyer, PhDKatie Mack @astrokatie.com · 28/01/2025I think some people hear “grants” and think that without them, scientists and government workers just have less stuff to play with at work. But grants fund salaries for students, academics, researchers, and people who work in all areas of public service. “Pausing” grants means people don’t eat.washingtonpost.comWhite House pauses all federal grants, sparking confusionThe Trump administration has put a hold on all federal financial grants and loans, affecting tens of billions of dollars in payments. 15754323914329
Reposted by Christy Niemeyer, PhDMike Fainzilber @mfainzilber.bsky.social · 28/01/2025“Shock and awe” at NIH returns to a new version of routine existential terror… www.science.org/content/arti...science.orgNIH memo addresses ‘confusion’ about restrictions imposed by Trump, easing some concernsMemo from acting director to staff allows some purchasing, and suggests travel and study sections could soon resume 066
Reposted by Christy Niemeyer, PhDJimmy Dooley @jimmycdooley.bsky.social · 04/12/2024Now that we’re on Bluesky, it’s a good time to bring back #badsciencedrawings – a collection of figures that prove that science is more science than art. Before Biorender, all we had was MS Paint and a dream. But ovals, lines, and lightning bolts were all we needed Morales-Botello et al., 2012 515845
Reposted by Christy Niemeyer, PhDMonica Carson @brainimmunity.bsky.social · 01/12/2024How much of age associated #microglia dysfunction in #Alzheimers disease is due to activation of LINE retrotransposons? Fun #openaccess study exploring this hypothesis - worth a read. #neuroinflammation #neurosky 061
Reposted by Christy Niemeyer, PhDMonica Carson @brainimmunity.bsky.social · 21/11/2024In #neuroinflammation, lineage matters….check out this preprint of long term engraftment of blood derived- #macrophages vs brain resident #microglia in #TBI # neuroskyence 0145
Reposted by Christy Niemeyer, PhDShannon Macauley @macauleylab.bsky.social · 19/11/2024Microglia-Dependent and Independent Modulation of Brain Lipid Metabolism in Alzheimer's Disease Revealed by Pharmacological and Genetic Microglial Depletion 03111
Reposted by Christy Niemeyer, PhDCarolyn Bertozzi @carolynbertozzi.bskyverified.social · 26/11/2024Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD. www.science.org/doi/10.1126/...science.orgRestoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologiesImpaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo... 420947
Reposted by Christy Niemeyer, PhDEwan St. John Smith @psalmotoxin.bsky.social · 26/11/2024👏 to Tetsuo Hasegawa & others of Clatworthy lab & beyond for this amazing analysis of macrophage-nociceptor interactions within the joint: the blood-joint barrier, "equipped to sense circulating stimuli & telegraph their presence via pain" #neuroskyence #PainResearch www.nature.com/articles/s41...nature.comMacrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge - Nature ImmunologyWhy joints are highly responsive to systemic inflammation is unknown. Hasegawa et al. sought to address this question, developing a whole-mount imaging system of the entire synovium to profile the vas... 23611
Reposted by Christy Niemeyer, PhDMichael Ward @michael-e-ward.bsky.social · 21/11/2024www.nature.com/articles/s41...nature.comTau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease - Nature NeuroscienceUsing cryo-electron tomography (cryo-ET) and proteomics, this study identifies the tethering of pathological tau filaments within defined brain extracellular vesicles in Alzheimer’s disease, shining l... 08317
Christy Niemeyer, PhD @csniemeyerphd.bsky.social · 21/11/2024Fluorescent Friday brought to you by microglia (🟢) surrounding HSV-1 infection (🟣) and counterstained with DAPI (🔵). Taken from our recently published paper. journals.asm.org/doi/10.1128/... 010
Reposted by Christy Niemeyer, PhDMonica Carson @brainimmunity.bsky.social · 20/11/2024This threaded discussion on sex differences in mechanisms leading to Alzheimer’s disease and neurodegeneration is worth a read. #microglia, #neuroinflammation 0125
Reposted by Christy Niemeyer, PhDSterre de Boer MD PhD @sterredeboer.bsky.social · 20/11/2024I love how kind everyone is on Bluesky! X is giving #reviewer2 vibes and Bluesky is like a kind reviewer 1! #Academia #endFTD 081
Reposted by Christy Niemeyer, PhDAndrew Mendiola @andrewmendiola.bsky.social · 20/11/2024I created a simple flow chart to help my lab trainees choose the most appropriate stats test in Prism (*for single-factor comparisons only). Feel free to share with your group if you think it could be helpful first start. 2026088
Reposted by Christy Niemeyer, PhDFernando González Ibáñez @fgi-em-neuro.bsky.social · 20/11/2024I like microglia and I like electron microscopy. Today my new review on microglia ultrastructure came out on Open Biology. doi.org/10.1098/rsob... I tried to do a guide I wish I had on my PhD. Thankful for all the people that have taught me microglia EM #microglia #electronmicroscopy #tremblaylab 2164
Reposted by Christy Niemeyer, PhDAndrew Bubak, PhD @andrewbubakphd.bsky.social · 18/11/2024Just joined and happy to see our recent work highlighted here! 061
Reposted by Christy Niemeyer, PhD#SingleCell preprints @prepub-singlecell.bsky.social · 06/10/2024Persistently primed microglia restrict the reactivation of latent cytomegalovirus at the expense of neuronal synaptic connectivity #singlecell www.researchsquare.com/article/rs-5… 031
Christy Niemeyer, PhD @csniemeyerphd.bsky.social · 18/11/2024I’ll start off strong by highlighting the wonderful work we are doing over here! 020