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Csaba Pal Laboratory

@csabapallab.bsky.social
288 followers 325 following 32 posts

Csaba Pal Lab's interest includes antibiotic resistance research, systems biology, and microbial experimental evolution. Account run by lab members. Szeged, Hungary group.szbk.u-szeged.hu/sysbiol/pal-…

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Csaba Pal Laboratory @csabapallab.bsky.social · 16/06/2026
Can #gene-loss fuel future #adaptation? Check out this exciting new study from @balazs-papp-lab.bsky.social showing that #compensatory-evolution can generate unexpected metabolic gains. Delighted to have contributed! Congratulations to everyone involved! 👏
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Csaba Pal Laboratory @csabapallab.bsky.social · 10/04/2026
🎓 Warm congrats to Elvin Maharramov @m-elvin.bsky.social on a successful PhD defense on the principles of designing #antibiotics with limited #resistance. A timely and elegant contribution to the field of #DrugDevelopment on how to design less resistance-prone antibiotics. More info below👇
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Csaba Pal Laboratory @csabapallab.bsky.social · 05/02/2026
Excited to share our collaborative work led by the Szilvia Juhasz and Mate Manczinger @matemanc.bsky.social labs: #cancer mutations converge into five protein-level “fingerprints” that shape tumor immune visibility. Mutation burden alone fails to predict #immunotherapy response! @molsystbiol.org
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Reposted by Csaba Pal Laboratory
Waggoner Lab @labwaggoner.bsky.social · 19/11/2025
C > U mutations generate immunogenic peptides in SARS-CoV-2 @natcomms.nature.com @matemanc.bsky.social @csabapallab.bsky.social www.nature.com/articles/s41...
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Reposted by Csaba Pal Laboratory
Máté Manczinger @matemanc.bsky.social · 01/12/2025
C > U mutations generate immunogenic peptides in SARS-CoV-2 APOBEC enzymes—key players of the innate immune system—induce mutations that become fixed in viral genomes and enhance immune recognition. nature.com/articles/s41... #COVID_19 #Immunology #virus #infectiousdiseases #vaccine #Genetics
nature.com
C > U mutations generate immunogenic peptides in SARS-CoV-2 - Nature Communications
The effect of new viral mutations on T cell responses remains unclear. Here, Balogh et al. show that most new mutations in SARS-CoV-2 are C > U, a bias that leads to an enhanced T cell re...
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Reposted by Csaba Pal Laboratory
Science X / Phys.org @sciencex.bsky.social · 03/03/2025
A dual-target antibiotic strategy, combining membrane disruption with another cellular pathway, shows promise in reducing bacterial resistance, offering a new direction in combating antimicrobial resistance. doi.org/g855sh
phys.org
Study uncovers the core principles of low-resistance antibiotics
A study published in Nature Communications has revealed novel insights into bacterial resistance and offers a promising strategy for developing antibiotics that minimize the evolution of resistance.
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Reposted by Csaba Pal Laboratory
Christian Landry @christianlandry.bsky.social · 23/02/2025
We are looking for a postdoc in #EvolutionarySystemsBiology. Exciting science, amazing team, wonderful city! landrylab.ibis.ulaval.ca/research-opp... #evolution #synbio #systemsbiology #genomics
landrylab.ibis.ulaval.ca
Research opportunities | Landry Lab
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Csaba Pal Laboratory @csabapallab.bsky.social · 24/02/2025
🚨 Our latest research in @naturecomms.bsky.social shows a promising strategy for less resistance-prone #antibiotics. For details, see the thread below and read the paper “Exploring the principles behind antibiotics with limited resistance” here: #MEvoSky www.nature.com/articles/s41...
nature.com
Exploring the principles behind antibiotics with limited resistance - Nature Communications
This study shows that only those dual-targeting antibiotics limit resistance in Gram-negative pathogens that also target the membrane of the bacteria. This mechanism provides a basis for designing fut...
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Healthcare in Europe @healthcare-europe.bsky.social · 03/02/2025
Two recent studies led by 🇭🇺 @csabapallab.bsky.social find that resistance can develop against new 💊 antibiotics even before they are widely used, compromising their effectiveness from the start. #antibioticresistance #AMR
dlvr.it
New antibiotics can develop resistance before even hitting the market
Researchers from the HUN-REN Biological Research Centre, Szeged (Hungary), have made a concerning discovery about the future of antibiotics.
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Reposted by Csaba Pal Laboratory
Greg Medlock @gregmedlock.bsky.social · 27/01/2025
Alternative drug modalities/approaches are desperately needed to supplement the pipeline of antibiotics.
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Reposted by Csaba Pal Laboratory
balazs-papp-lab.bsky.social @balazs-papp-lab.bsky.social · 14/01/2025
ESKAPE pathogens are outsmarting us. Our latest paper in @naturemicrobiol.bsky.social reveals alarming ease of resistance evolution to antibiotics in development. Collaborative work with @csabapallab.bsky.social‬ and Kintses Lab
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Reposted by Csaba Pal Laboratory
Nature Microbiology @natmicrobiol.nature.com · 13/01/2025
💊🦠OUT NOW - comprehensive analysis of the propensity of ESKAPE pathogens to evolve resistance to new and in development antibiotics by Csaba Pal, Balint Kintses, Balazs Papp and colleagues. Dive in here... www.nature.com/articles/s41...
nature.com
ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro - Nature Microbiology
An extensive experimental analysis of resistance to antibiotics in development or introduced post-2017 in ESKAPE bacteria reveals the dynamics of resistance acquisition, mutational targets and the pre...
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Csaba Pal Laboratory @csabapallab.bsky.social · 13/01/2025
🚨 Excited to share that our new study, “ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro” is published in @naturemicrobiol.bsky.social. For details, see the 🧵below and read the paper here: www.nature.com/articles/s41...
nature.com
ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro - Nature Microbiology
An extensive experimental analysis of resistance to antibiotics in development or introduced post-2017 in ESKAPE bacteria reveals the dynamics of resistance acquisition, mutational targets and the pre...
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Csaba Pal Laboratory @csabapallab.bsky.social · 13/01/2025
Awesome! Many thanks ‪@thealexknapp.bsky.social‬ for spotlighting our recent work!
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Reposted by Csaba Pal Laboratory
Csaba Pal Laboratory @csabapallab.bsky.social · 13/01/2025
Thrilled to share our latest work, "Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance" in Science Translational Medicine! For details, see the thread below and read the paper here: www.science.org/doi/10.1126/...
science.org
Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance
Antibiotic candidates induce multidrug resistance in Staphylococcus aureus without compromising bacterial viability.
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Csaba Pal Laboratory @csabapallab.bsky.social · 13/01/2025
Thrilled to share our latest work, "Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance" in Science Translational Medicine! For details, see the thread below and read the paper here: www.science.org/doi/10.1126/...
science.org
Antibiotic candidates for Gram-positive bacterial infections induce multidrug resistance
Antibiotic candidates induce multidrug resistance in Staphylococcus aureus without compromising bacterial viability.
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Reposted by Csaba Pal Laboratory
Christian Landry @christianlandry.bsky.social · 09/01/2025
While writing papers and grants, we received many comments on the role of CNVs in antifungal resistance. We thought we should formally assess how important they are. Here is what we found. #AMR #fungi #evolution rdcu.be/d5rbN
nature.com
The role of gene copy number variation in antimicrobial resistance in human fungal pathogens
npj Antimicrobials and Resistance - The role of gene copy number variation in antimicrobial resistance in human fungal pathogens
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