Human leukocyte antigen class II (HLA-II) are involved in the presentation of peptides to helper T cells which guide in the B cell response and antibody production. Here Magyari et al, show that HLA-I...

Researchers from the HUN-REN Szeged Biological Research Centre and HCEMM have just published a new study suggesting that it’s not simply the number of tumour mutations that matters for immunothe...

Although numerous mutational processes operate in cancer, their functional impacts are unclear. We hypothesised that certain mutation sources preferentially generate amino acid substitutions that evad...

The effect of new viral mutations on T cell responses remains unclear. Here, Balogh et al. show that most new mutations in SARS-CoV-2 are C > U, a bias that leads to an enhanced T cell re...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...