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This study establishes granulocyte-monocyte progenitors as a renewable upstream platform for engineered myeloid cell therapy and introduces a CAR-Fc strategy that couples direct tumor targeting to hos...

Summary: Single-cell analysis and toolkit generation in zebrafish identifies gene regulatory codes and growth dynamics of distinct facial ligaments and tendons.

A method to produce embryonic stem cells for a range of bird species opens up opportunities in agriculture, developmental biology and species conservation.

Using a zebrafish genetic model of Ewing sarcoma, Vasileva et al. provide evidence for a neural crest origin of the disease. These findings offer new insight into how a single oncogenic fusion can hij...

Using a zebrafish genetic model of Ewing sarcoma, Vasileva et al. provide evidence for a neural crest origin of the disease. These findings offer new insight into how a single oncogenic fusion can hij...

Gills are essential for fish respiration and have a highly specialized cellular architecture enabling efficient gas exchange. Surprisingly, the developmental processes underlying gill formation in zeb...

The human pelvis exhibits distinct spatiotemporal ossification patterns and an ilium cartilage growth plate that is shifted perpendicularly compared with those of other mammals and non-human primates—...

Anyone who has ever squirmed through a dental cleaning can tell you how sensitive teeth can be. This sensitivity gives important feedback about temperature, pressure—and yes, pain—as we bite and chew ...

Evolutionarily conserved molecular program used to form gills and ears.

In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.