iiinova — where your digital self keeps evolving

Coleman Lab @colemanlab.bsky.social · 21/09/2026

Yet another AI productivity ‘win’. Destroying any ability to identify good science funding applications.

Coleman Lab @colemanlab.bsky.social · 02/06/2026

It is also the reason to split HR (a dreadful term) into employment law & coaching. Regulation is needed to prevent abusive, discriminatory or unreasonable practices but no employer will ever get the best out of employees by developing and enforcing more rules. And guess what? This matters too!

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Coleman Lab @colemanlab.bsky.social · 02/06/2026

If a scientist’s unconscious mind is working on a problem while they are asleep, gardening or walking, is that a ‘working’ day or a day’s leave? But if we work 24/7 as the ‘badge of honour’ fanatics suggest we ‘need to’ in order to survive what does that do to our creativity?

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Coleman Lab @colemanlab.bsky.social · 02/06/2026

Every scientist and HR professional working with scientists needs to listen to this podcast from the amazing Hidden-Brain series. It’s the reason I’ve never signed out a day’s leave in my life and never will. But it’s also why I make sure I take time off anyway. podcasts.apple.com/gb/podcast/h...

podcasts.apple.com

Unleashing Your Creativity

Podcast Episode · Hidden Brain · 1 June · 53min

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Coleman Lab @colemanlab.bsky.social · 01/06/2026

Not all grant rejections are equal. Some are more devastating than others. As a researcher, how do you keep going in those moments? The latest Science Without Anguish blog post discusses a topic we need to talk about much, much more! www.sciencewithoutanguish.com/blog/when-a-...

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Coleman Lab @colemanlab.bsky.social · 05/05/2026

You know what? Better critical thinking (even if AI can deliver it, which I doubt) won’t help. Because critical thinking is not the limiting factor in grant applications. I used to believe it too.

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Coleman Lab @colemanlab.bsky.social · 12/04/2026

Looking forward to talking to British Neuropathological Society and Edinburgh Neuroscience on Tue 14th April (1-2pm): 'The Overwhelm Trap' What is overwhelm? Why does it happen? How to avoid, or get out of it edinburghneuroscience.ed.ac.uk/the-overwhel... See also www.sciencewithoutanguish.com

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Coleman Lab @colemanlab.bsky.social · 12/04/2026

Congratulations to Laura Carlton and Emma Wilson on these exciting findings, their first primary research articles as first and senior author respectively. Also thanks to Heba Morsy for in silico analysis of promoter sequences. We look forward to working constructively with reviewers.

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Coleman Lab @colemanlab.bsky.social · 12/04/2026

Importance: These findings will support disease association studies link programmed axon death to specific human diseases. It is essential to move beyond the limitations of animal models and work directly in humans to understand where best to apply drugs blocking programmed axon death. 4/5

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Coleman Lab @colemanlab.bsky.social · 12/04/2026

(2) Several rare variants lower hNMNAT2 expression. These are likely to increase risk of programmed axon death (3) One arose in an ALS patient in Project MinE (4) A common variant in the SARM1 promoter significantly increases expression, also potentially raising the risk of programmed axon death 3/5

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Coleman Lab @colemanlab.bsky.social · 12/04/2026

SARM1 is a protein that drives axon degeneration. NMNAT2 suppresses its activity to keep axons healthy. Their expression levels are fundamentally important to axon health. Key points: (1) Identification of distinct regions that boost and suppress hNMNAT2 and hSARM1 expression 2/5

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Coleman Lab @colemanlab.bsky.social · 12/04/2026

Delighted to announce the latest preprint from our amazing team: www.biorxiv.org/content/10.6... Laura Carlton and Emma Wilson report luciferase mapping of the human NMNAT2 and SARM1 promoters, naturally-occurring human gene variants within them and their functional consequences. 1/5

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Coleman Lab @colemanlab.bsky.social · 15/12/2025

Today in Science Without Anguish: 'It's not what you know, it's who you....trust'. When knowledge is really trust in disguise. And not absolute but greyscale. Why knowing this helps us cope when our knowledge is challenged. www.sciencewithoutanguish.com/blog/its-not...

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Coleman Lab @colemanlab.bsky.social · 01/12/2025

Today in Science Without Anguish: how we handle experiences that don’t fit our mental map. The many ways that cognitive dissonance plays out in academic research and the problems this causes us. www.sciencewithoutanguish.com/blog/to-chan...

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Coleman Lab @colemanlab.bsky.social · 20/11/2025

I reviewed my success rate for an ECR mentoring talk. Surprisingly I noticed the funding decisions on proposals made 15-25y ago bore little resemblance to which had the best plans with benefit of hindsight. A big lesson in what rejections mean and don’t mean. But they still hurt!

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Coleman Lab @colemanlab.bsky.social · 19/11/2025

Thanks for sharing. The more we do that, the easier it gets for us all and the fewer great young scientists we lose from research because of total misunderstanding about what rejection does and doesn’t mean.

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Coleman Lab @colemanlab.bsky.social · 19/11/2025

Science WITH Anguish? Grant rejection today. It never stops hurting no matter how successful or how many you dealt with before (this is no. 57). Thanks to my team for helping me handle it today. 😀 Tomorrow we go on. ECRs dealing with rejection: you are not alone! Hot tip: saying this helps me too!

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Coleman Lab @colemanlab.bsky.social · 17/11/2025

Today in Science Without Anguish: Is blame bringing you down? How we shackle ourselves by blaming others, also degrading workplace culture and raising our stress levels. But can we avoid it without blaming ourselves instead? www.sciencewithoutanguish.com/blog/is-blam...

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Coleman Lab @colemanlab.bsky.social · 03/11/2025

Today in Science Without Anguish: how failing to notice when the wind is behind us makes us believe the world is against us when things don’t go our way. www.sciencewithoutanguish.com/blog/im-good...

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Coleman Lab @colemanlab.bsky.social · 20/10/2025

In this week’s Science Without Anguish: ‘Short cuts to lost potential’. How confusing the simplifications we make to understand the world with the real thing can lead us astray. www.sciencewithoutanguish.com/blog/the-sho...

sciencewithoutanguish.com

The short cuts to lost potential

We know how it goes – a day spent reacting to other people’s emails or “quick chats” while our own to do list remains untouched at the end. Or losing ourselves in the first item on our list...

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Coleman Lab @colemanlab.bsky.social · 13/10/2025

Science Without Anguish series 3 This week: the mistakes we make understanding our world that we would never make in our science www.sciencewithoutanguish.com/blog/heurist... Coming up next week: how what grabs our attention most and first impressions skew our thinking.

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Coleman Lab @colemanlab.bsky.social · 06/10/2025

This week in Science Without Anguish: how simplifying our view of the world based on limited evidence can lead us astray. www.sciencewithoutanguish.com/blog/heurist...

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Coleman Lab @colemanlab.bsky.social · 29/09/2025

Science Without Anguish series 3: out now! www.sciencewithoutanguish.com/blog/dont-be... Could clear thinking about research life make it easier? Next week: The short cuts our minds use to make sense of the world and the problems this can lead to.

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Coleman Lab @colemanlab.bsky.social · 22/09/2025

Science Without Anguish Series 3 in out: Don’t believe everything you think! Confusing our mental shortcuts with reality. Excusing ourselves but blaming others. Not realising we’re doing it and making life harder for ourselves in the process. www.sciencewithoutanguish.com/blog/dont-be...

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Coleman Lab @colemanlab.bsky.social · 20/09/2025

How much of what we think we ‘know’ is just trust in the person that told us? And what price do we pay for confusing the two? Coming soon in Science Without Anguish: ‘Don’t believe everything you think!’ sciencewithoutanguish.com Starts Monday 22nd Sep

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Coleman Lab @colemanlab.bsky.social · 18/09/2025

Science Without Anguish Series 3 starts Monday 22nd 'Don't believe everything you think!'. sciencewithoutanguish.com How heuristics & biases make our research lives more difficult and ways to reduce this. Stereotyping, snap judgements, confirmation bias, attribution errors, negativity bias….

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Coleman Lab @colemanlab.bsky.social · 18/09/2025

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Coleman Lab @colemanlab.bsky.social · 25/08/2025

Very exciting opportunity here to work with former member of our group and rising star @andrea-loreto.bsky.social Highly recommended!

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BWJones @bwjones.bsky.social · 06/05/2025

Morale? I have colleagues there who are leaving NIH for jobs in China, France, Canada, industry, or retiring early. That’s real.

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Coleman Lab @colemanlab.bsky.social · 04/05/2025

Great to see @maxstetina.bsky.social here. Max did a very productive internship with us last year looking at evolutionary conservation of SARM1 and NMNAT2.

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Coleman Lab @colemanlab.bsky.social · 07/04/2025

“Smile!”, they said, “Things could be worse.” So I smiled …. and they did get worse. 😢

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Prof Sarah-Jayne Blakemore @sjblakemore.bsky.social · 07/04/2025

I wrote an Article about the Netflix drama, Adolescence. Free version here archive.is/goNeQ

archive.is

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Mike Fainzilber @mfainzilber.bsky.social · 07/04/2025

Not sure if to laugh or to cry, but worth hearing either way…

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Coleman Lab @colemanlab.bsky.social · 01/04/2025

So sorry Bryan. Wishing you strength at this difficult time.

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Claire Durrant @clairedurrant1.bsky.social · 01/04/2025

Amazing to welcome HRH The Duchess of Edinburgh, Patron of Race Against Dementia to our lab! An incredible opportunity to showcase our work with living human brain slice cultures and the importance of investing in dementia research. We are very lucky to have her support.

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John Higgins @jhigginswriter.bsky.social · 09/03/2025

Next up: NASA to review heliocentric model of solar system

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WuTangIsForTheChildren @wutangforchildren.bsky.social · 08/03/2025

Perfect meme doesn’t exi….🤣🎯

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Coleman Lab @colemanlab.bsky.social · 09/03/2025

When I was a postdoc people used to talk about the “brain drain” of our brightest scientists moving to the US. Now there is a once in a lifetime opportunity for the whole of Europe to put that into reverse…IF we fund science properly.

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Cahir O'Kane @cahirokane.bsky.social · 08/03/2025

Postdoctoral by-fellowships at @churchillcol.bsky.social Closing date next Friday 14th March at 12:00 midday!

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Mike Cohen @michaelnadbio.bsky.social · 07/03/2025

Grateful for all the people mobilizing across the US and the world for #StandUpForScience! Many reasons motivating this movement, but yesterday as I was reviewing undergrads applications for summer internships, I was reminded of how important this is for the next generation of scientists.

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Richard Sever @richardsever.bsky.social · 07/03/2025

Chalfie: “we should recruit those who have traditionally been excluded [into science]. We need their intelligence and perspective. I strongly believe in DEI” #standupforscience2025 NYC

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Ashley Kalinski @kalinskilab.bsky.social · 07/03/2025

Making our voices heard! Keep at it y’all! 🧪🧠👩‍🔬🫶 #standupforscience2025

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Daniela Barillà @danielabarilla.bsky.social · 04/03/2025

Can I tempt some young minds to consider Old York for a PhD? Some days left to apply. Open to applicants WORLDWIDE 🌎.

River Ouse at sunset with some orange light on the horizon.

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