Probabilistic sequence encoding from language model embeddings within a generative AI framework enables protein miniaturization, modification and augmentation while maintaining native architecture and functional integrity.

Abstract. l-Asparaginases have been essential anticancer biopharmaceuticals for nearly half a century, particularly in the treatment of acute lymphoblastic

The TIM barrel is nature’s most versatile enzyme fold, yet de novo variants lack functional active sites. Minimal de novo TIM barrels have now been converted into enzymes by designing structural lids ...