ALT: Cowboy Scans Desert Horizon with Telescope

Cobb looks back at the complicated series events that led to the discovery of messenger RNA, highlighting the often difficult problem of attributing credit for scientific advances.

Decapping is a key step in mRNA decay, but how its regulation has diverged across eukaryotes remains unclear. Here, the authors reconstitute the human decapping network, revealing divergent roles for ...

About the Conference Codon usage bias—the preference for certain synonymous codons—is a key factor in genome regulation. Codon usage and synonymous codon mutations have been shown to influence gene ex...

Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...

Meeting background RNA molecules are at the heart of normal physiological processes, and their dysregulation can drive a wide range of human diseases. This international meeting will bring together wo...

Nature Communications - The type I interferon response is suppressed during early development, making embryos susceptible to pathogens. Here, the authors show that this suppression contributes to...

The Danish American who doubted Covid shots is meant to lead drug regulation – but has focused on vaccines

Alt: A green and white sea sheep grazes on a green lawn of algae on a surface underwater.

Designing single molecules capable of complex sensing functions is challenging. Now, using crowdsourced RNA designs from the online game Eterna, compact single-molecule sensors have been demonstrated ...

Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...

Evolution has shaped the genetic code, with subtle pressures leading to preferences for some synonymous codons over others. Codons are translated at different speeds by the ribosome, imposing constrai...