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Chiara Manzini

@chiaraman.bsky.social
212 followers 413 following 46 posts

Neuroscientist. Human, mouse, and zebrafish geneticist. Trying to understand and treat neurodevelopmental and neuromuscular disease. If you recognize my avatar from the OG #scitwitter crowd, give me a follow and say Hi.

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Reposted by Chiara Manzini
Amanda Litman @amandalitman.bsky.social · 26/06/2025
Generational change is coming: Since Zohran Mamdani won on Tuesday night, more than 1100 young people have reached out to @runforsomething.net to explore a run for local office -- one of our biggest spikes of the year yet.
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Abby Polter @ampolter.bsky.social · 15/05/2025
I am thinking a lot today about how heavy things feel in my world of faculty doing scientific research. There's the immediate chaos and panic about our ability to pay people and continue our research. But there's also a deeper grief at watching everything get bulldozed for no reason
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Justin Hendrix @justinhendrix.bsky.social · 09/05/2025
The mayor of an American city exercising his constitutional rights being detained by force by armed, masked federal officers wielding batons.
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Jeremy Berg @jeremymberg.bsky.social · 02/05/2025
Bluetorial: Timing of getting grants out the door at NIH The pauses and low rate of releasing awards may be a problem in terms of getting the NIH appropriation spent by September 30, 2025
media.tenor.com
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
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Andrew Hardaway @andrewhardaway.bsky.social · 30/04/2025
My trainee's F31 diversity from NIDDK "terminated" today. We received a NGA for $0.00. He worked his butt off for it and would have been competitive in the normal F31 pool. This is just blatant discrimination. If there are large lawsuits being put together, please share that info. #contractlaw
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Rebekah @rebeccaharkness.swifties.social · 28/04/2025
This was the most accurate account I have seen done. Made me tear up a few times. So much trauma in such a short amount of time.
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 24/04/2025
Hearing that NIH Research Fellows are being terminated willy-nilly by the DOGE and MAGA HHS crew. These are senior experienced scientists that NIH wants to keep, but HHS is blocking their renewal. This harms cancer research, and dementia, food, opiate, and mental health
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Sam Wang @samwang.bsky.social · 23/04/2025
SCIENTISTS: Schedule F is proposed, and it's here for your peer review. Rules/regulations have the force of law. This rule, Schedule F potentially puts peer review into the hands of political appointees, and undermines the civil service. Public comment here: www.federalregister.gov/documents/20...
federalregister.gov
Improving Performance, Accountability and Responsiveness in the Civil Service
The Office of Personnel Management (OPM) is proposing a rule to increase career employee accountability. Agency supervisors report great difficulty removing employees for poor performance or misconduc...
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Lucia Peixoto @sciencenlucia.bsky.social · 21/04/2025
April is #Autism Awareness Month. This is a month to accept, understand and love those in the Autism Spectrum. Above all accepting that someone is different and respecting their differences is the most important thing we can do. Here are some facts to help understand (a thread):
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Citizen Snippy △ @citizensnippy.bsky.social · 21/01/2025
85 years ago, Charlie Chaplin delivered his famous speech at the end of his first film with dialogue - The Great Dictator. He spoke these timeless words as Nazis rose to power, and the drums of war beat in Europe, echoing across the world. As relevant, and necessary to hear, today as ever #Resist
youtube.com
Charlie Chaplin - Final Speech from The Great Dictator
YouTube video by Charlie Chaplin
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Angela @antiangie.bsky.social · 11/04/2025
This is a discussion at every research university right now and the biggest issue is that it is simply not sustainable. Bridge funding is meant to be a short-term solution and this is a long-term problem. Private philanthropy simply cannot replace public support.
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Ted McCormick @tedmccormick.bsky.social · 11/04/2025
Curtailing people’s ability to read widely and carefully, to locate, assess, and compare different sources for themselves, and to write in their own voice about what they find and what it means, is arguably more effective than censorship. It is also one of the most obvious effects of generative AI.
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Sarah Stern @sarahstern.bsky.social · 09/04/2025
If you’re a scientist whose funding has recently been cut or impacted, I would love to interview you and amplify your work! Hoping to release our first two podcast episodes next week. Please share widely!
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Dr. Lucky Tran @luckytran.com · 07/04/2025
Do not normalize children dying from measles. Measles was previously eliminated in the US, thanks to vaccines. When children die from measles, it means that adults have catastrophically failed to protect them because they have rejected basic science.
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andy vs. @im-all-id.me · 07/04/2025
Democratic leaders act like time travelers afraid to do anything that might change the future
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Maureen Barr @barrlab.bsky.social · 05/04/2025
Jersey strong @booker.senate.gov #handsoff
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Chiara Manzini @chiaraman.bsky.social · 05/04/2025
The Hands Off March in NYC had an amazing turnout! Walked back home close to the start and people were still coming 2 hours later...
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Dr. Lucky Tran @luckytran.com · 05/04/2025
Spectacular view of 100,000 people attending the #HandsOff march in NYC
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Maureen Barr @barrlab.bsky.social · 03/04/2025
"If we cut or limit funding for curiosity-driven research, we risk shutting down the pipeline of future innovation. While the outcomes of basic science may seem unclear or esoteric at first, such work frequently forms the bedrock of future technologies, treatments, and therapies." 👏👏👏
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Dr. SkySkull @drskyskull.bsky.social · 31/03/2025
Do y’all know how much you have to piss off those three to get them to work together
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The New York Times @nytimes.com · 31/03/2025
23andMe, maker of popular DNA test kits, has filed for bankruptcy and is looking for a buyer. Here’s why customers should delete their info before it’s sold. nyti.ms/42cnBma
A quote from Max Eddy, a Wirecutter writer covering privacy, security and software: “There’s not a lot of regulations around the kind of data that 23andMe and other companies like it are holding. This information is not covered by HIPAA, which is legislation that limits how far medical information could be spread.”
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Chiara Manzini @chiaraman.bsky.social · 27/03/2025
Good riddance. As a geneticist, I would have never given them my data they were sus from the beginning. A friend just posted a way to retrieve your data and delete it from their servers. Hope it's true 👇🏼
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Burgess Everett @burgessev.bsky.social · 12/03/2025
Schumer on Senate floor: "Funding the government should be a bipartisan effort, but Republicans chose a partisan path" "Because of that Republicans do not have the votes in the Senate to invoke cloture on the House CR. Our caucus is unified" on the month-long CR
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Chiara Manzini @chiaraman.bsky.social · 12/03/2025
As a NYer without a car congestion pricing has been magical. It's so much easier to get around and even my friends in NJ like it because they can find free street parking and coming into the city at night is overall cheaper. Now, please fix the subway!!
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Susanne Ahmari @ahmarilab.bsky.social · 11/03/2025
I know- it is absolutely devastating. Without a T32, I would have needed an NRSA (I did very different work from my mentor). But they're cutting the NRSAs too... so I would have been out of science. And the new OCD treatment now in clinical trial that started from my T32 would never have happened 😩
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Stacy Farina @stacyfarina.bsky.social · 11/03/2025
They are coming for your institution at some point. And it doesn't matter how much your institution does to capitulate or comply in advance. It all ends the same way. So put pressure on your institutions not to comply in advance! No collaboration with fascists.
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Jeremy Berg @jeremymberg.bsky.social · 11/03/2025
I have confirmation from several sources now that all T32s, many F30s and F31s, and most or all Center awards (P30, P50) have been terminated at Columbia. This is quite damaging to research and to individuals. This is pure terrorism and cannot be legal. But litigation will take time...
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Erin Biba @erinbiba.bsky.social · 09/03/2025
We have to remember that the American public being misinformed and lacking knowledge of what’s happening right now is only their fault *to an extent* Our entire media ecosystem has been purchased and controlled by billionaires and oligarchs. A misinformed public is MANUFACTURED AND INTENTIONAL.
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 07/03/2025
The @standupforscience.bsky.social DC rally is on. What we are hearing from around the country: "this is big!" "biggest rally I have seen around here in years and years" The public cares about medical research--and students, GenZ, and other people too are ready to stand up.
Crowd at Lincoln memorial
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Andrew Werth @andrewwerth.com · 07/03/2025
Good crowd at the #StandUpForScience2025 rally in Trenton, New Jersey, today.
Crowd at the Stand Up For Science rally in Trenton, NJ, on Mar 7, 2025
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Tim Mosca (he/him) @drosophilosophy.bsky.social · 07/03/2025
"Philadelphia, the scientists of America need us" @sarahmackattack.bsky.social teaches Stand Up for Science Philly about the good of chaos!! #standupforscience2025
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Chiara Manzini @chiaraman.bsky.social · 07/03/2025
The mad scientists are out in Trenton #standupforscience
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Christophe 🔬 Leterrier @christlet.bsky.social · 07/03/2025
More white coats, less white robes! @eddpasquier.bsky.social #standupforscience #standupforscience2025
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Max Planck Institute for Molecular Genetics @molgen.mpg.de · 07/03/2025
#StandUpForScience👩‍🔬👨‍🔬📢Scientists at the Max Planck Institute for Molecular Genetics in Berlin, including our managing director, show solidarity with our colleagues in the US who are protesting against the attacks of the current US administration. @standupforscience.bsky.social @maxplanck.de
Scientists standing in front of the Max Planck Institute for Molecular Genetics holding signs "#StandUpForScience"
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Kathryn Macapagal @karmacap.bsky.social · 07/03/2025
“The law of gravity works for you, regardless of who you voted for,” @cdelawalla.bsky.social said. If you used your cellphone today, or knew the name of a bird outside your window or brushed your teeth last night, she added, “it’s because of a scientist.” Thanks for your vision. #standupforscience
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Trisha Clark @tcinindy.bsky.social · 07/03/2025
Good thread 🧵 on policy change for NIH peer review process. You should review the full thread. It expresses many of my same concerns. If you aren’t following @jeremymberg.bsky.social, you should. He’s a great resource and provides a great perspective on these issues. #NIH #Science #Medsky #RAdminsky
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Chiara Manzini @chiaraman.bsky.social · 07/03/2025
Everyone is ready for the Stand Up for Science rallies tomorrow!
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Maureen Barr @barrlab.bsky.social · 06/03/2025
JERSEY!!!! ARE YOU READY?!?! 💪🧪 Our #StandUpForScience2025 closing speaker is @samwang.bsky.social! See you at the Trenton State Capitol Plaza tmrw March 7 12-2pm. www.eventbrite.com/e/stand-up-f...
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Becca Riggins 🇻🇮 ⛵️🧪 @profriggins.bsky.social · 05/03/2025
❤️ Just covered this paper, and a few others on this topic, in our Minority Health and Health Disparities course within my breast cancer disparities lecture.
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Chiara Manzini @chiaraman.bsky.social · 05/03/2025
$8M including indirects is a few grants. It is likely research on the effects of hormone replacement or gender confirmation surgery using mouse models. It's valid peer-reviewed research. Most of the programs he mentioned in foreign countries sounded amazing and promoted democracy 😢
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Bethany Brookshire @beebrookshire.bsky.social · 04/03/2025
So this company is showing off their mice with woolly coats and saying we genetically altered them to be more like woolly mammoths! Ok the mice are cute. But they're ignoring the fact that...WOOLLY MICE EXIST. www.theguardian.com/science/2025... Let me introduce you all to: The mouse Fancy.
theguardian.com
Scientists aiming to bring back woolly mammoth create woolly mice
Genetically modified mice have traits geared towards cold tolerance, in step towards modifying elephants
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Chiara Manzini @chiaraman.bsky.social · 04/03/2025
Remember we rally on Friday! Spread the word. 💪🏼🧪🧬🧫
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Hillary Monahan @hillarymonahan.bsky.social · 03/03/2025
A cross stitch pattern of the Oregon trail with the caption you listened to RFK.

Credit to @institchesbysara
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Chiara Manzini @chiaraman.bsky.social · 03/03/2025
A friend who develops LLMs was explaining the new "reasoning" features in DeepSeek and now Claude, so I did some testing on my own. I was writing a review article and I find Claude can be quite helpful with editing, but I pushed him/it a little bit. In addition to editing for fluency and grammar...👇
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DrArchivalGenomics @ehekkala.bsky.social · 02/03/2025
We march on Friday #StandUpForScience
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 01/03/2025
Francis Collins, longtime NIH director with bipartisan bona fides*, retires as of yesterday. He returned to NIH in 2023 to focus on research in his own lab, in the NIH in-house intramural research campus. His letter seems to imply he wasn’t ready to leave. NIH is being torn down. 1/🧪 #academicsky
Statement by Francis Collins, MD. PhD
March 1, 2025 Yesterday I notified NIH Acting Director Matt Memoli, MD of my retirement from the federal government.
effective February 28, 2025. The National Institutes of Health is the world's foremost medical research institution. It has been rightfully called the "crown jewel" of the federal government for decades. It has been the greatest honor of my life to be part of this institution in various roles
over the last four decades. In the 1980s, NIH supported my work at the University of Michigan through a peer-reviewed grant. That led
to the identification of the gene for cystic fibrosis. Thirty years later that has led to an almost miraculous treatment that allows most kids with cystic fibrosis to
look forward to an almost normal life span. I was recruited to NIH in 1993 to lead the Human Genome Project - an extraordinarily bold initiative to read out the three billion letters of the human DNA instruction book. Funded by the U.S. Congress, the project completed its work -- two years ahead of schedule, and $400 million under budget. The success of the project, and the commitment to share all of the data rapidly and freely, has revolutionized every aspect
of human biomedical research and medical practice. Subsequently I was honored to be asked to serve as the Director of the National Institutes of Health. I had the chance to serve three Presidents - Barack Obama, Donald Trump, and Joseph Biden. I also had the opportunity to work regularly
with members of Congress in both parties. I loved those interactions and
relationships.
Throughout that time, investmentrelieving
human suffering, and
contributing
substantially to the U.S. economy.
That consistent
support
made
possible
bold
new projects
in regenerative medicine, brain science, precision health, cancer, and solutions for opioid addiction, to name just
a few. When the worst pandemic in more than a century arose in 2020, it was my job as Director of NIH to pull together partnerships with the FDA, academia, and the private sector to produce what only America's unparalleled biomedical sector could have: COVID vaccines in just 11 months, a staggering medical
achievement that saved over three million lives in the
U.S.alone. After a stint in the White House as the President's Acting Science Advisor, where I had the chance to organize a major initiative to eliminate hepatitis C in the United States, i returned to the intramural research program of the National Human Genome Research Institute in 2023. There I have been overseeing a research laboratory of a dozen highly talented and visionary scientists who are providing new insights into the causes and possible means of prevention of type 2 diabetes, as well as seeking a gene therapy cure for one of the world's rarest diseases - progeria, a
premature aging disorder. NIH is the largest supporter of biomedical research in the world. It is the main piston of a biomedical discovery engine that is the envy of the globe. Yet it is not a household name. It should be. NIH supports everything from basic science to clinical trials,
providing the foundation of many breakthroughs. When you hear about patients surviving stage 4 cancer because of immunotherapy, that was based on NIH research over many decades. When you hear about
sickle cell disease being cured because of CRISPRgene editing, that was built on many years of research supported by NIH. It has also been the largest supporter of global health research in the world, winning us many friends and colleagues from across
the globe. I have loved being employed by this extraordinary, life-giving institution for 32 years. I will continue to devote my life in other ways to seeking knowledge and enhancing health, to healing disease and reducing suffering, and to doing what I can to bring together our fractured communities around the shared values of love, truth, goodness, and faith. As I depart NIH, I want to express my gratitude and love for the men and women with whom I have worked side-by-side for so many years. They are individuals of extraordinary intellect and integrity, selfless and hard-working, generous and compassionate. They personify excellence in every way, and they deserve the utmost
respect and support of all Americans.
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Chiara Manzini @chiaraman.bsky.social · 28/02/2025
Even if the NIH cancelled their event, it's still Rare Disease Day! We work on rare neurodevelopmental disorders sometimes also affecting the muscle. We are thankful for the families, clinicians and collaborators helping with our studies. ❤️ #RareDiseaseDay #ShowYourStripes
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Chiara Manzini @chiaraman.bsky.social · 28/02/2025
My most painful childhood memories are measles (3), chickenpox (5) and mumps (6). I had a lot of respiratory issues after the measles and I never had a fully developed sense of smell. I also had shingles twice as a young adult. Why willingly put a child though this? 👇🏼 www.nytimes.com/2025/02/28/o...
nytimes.com
Opinion | The Texas Measles Outbreak Is Even Scarier Than It Looks
Kennedy may not be worried, but everyone else should be.
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Jeremy Berg @jeremymberg.bsky.social · 27/02/2025
UPDATE ON FUNDING These are data through 2/21/25. The lag in Reporter really does appear to be about a week. There was a second mini-pause as suspected from internal reports, but grants are being awarded. About 21% new or competitive renewals (compared to 29% in 2017, and 22% in 2021
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samuel mehr @mehr.nz · 27/02/2025
seriously PIs, talk to your contacts at NIH, NSF, etc. they're trying to help this morning I chatted with the SRO of my cancelled study section, she's already working to reschedule it I thanked her for making it work, & just said it meant a lot to me that SROs, POs, etc are keeping science going
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