✨ Highlights:
🔹 BIN1 is enriched at inhibitory synapses
🔹 Loss-of-function (shRNA/LOAD mutants) → loss of inhibitory synapses, hyperactivity
🔹 Effects are independent of Aβ
🔹 Levetiracetam rescues function
#SynapseBiology #Neurodegeneration
Neuroscience 🧠 Cell Biology 🧫 PI neuronal trafficking in aging laboratory 🥼 iNOVA4Health NOVA Medical School Lisbon 🇵🇹neuron cell biology 🧫 microscopy 🔬bio imaging 💻endosomes 😊synapses ⚡️Alzheimer’s Disease 🧠🧪