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Claudia Guimas Almeida

@cgalmeida.bsky.social
320 followers 422 following 22 posts

Neuroscience 🧠 Cell Biology 🧫 PI neuronal trafficking in aging laboratory 🥼 iNOVA4Health NOVA Medical School Lisbon 🇵🇹neuron cell biology 🧫 microscopy 🔬bio imaging 💻endosomes 😊synapses ⚡️Alzheimer’s Disease 🧠🧪

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Claudia Guimas Almeida @cgalmeida.bsky.social · 17/07/2025
✨ Highlights: 🔹 BIN1 is enriched at inhibitory synapses 🔹 Loss-of-function (shRNA/LOAD mutants) → loss of inhibitory synapses, hyperactivity 🔹 Effects are independent of Aβ 🔹 Levetiracetam rescues function #SynapseBiology #Neurodegeneration
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Claudia Guimas Almeida @cgalmeida.bsky.social · 17/07/2025
🧠 What if Alzheimer’s risk starts at the synapse? In our new study led by Mariana Barata, we show that BIN1, a key AD risk gene, regulates inhibitory synapses—loss of BIN1 → hyperexcitability before Aβ. www.cell.com/cell-reports...
cell.com
Alzheimer’s genetic risk factor Bin1 controls synapse vesicle exo-endocytosis in inhibitory synapses
Barata et al. show that the Alzheimer’s risk gene BIN1 is critical for the stability of inhibitory synapses. BIN1 deficiency accelerates the synaptic vesicle endocytic cycle, leading to synapse loss a...
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Richard Sever @richardsever.bsky.social · 11/03/2025
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n
openrxiv.org
Homepage - openRxiv
openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.
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Jonasnuts @jonasnuts.bsky.social · 09/03/2025
Pronto.... já nasceu a criança. escolho.eu Participem, colaborem, contribuam :-)
escolho.eu
Home | Escolho a Europa
escolho.eu. Está na hora de escolher a Europa. Está nas nossas mãos fortalecer a economia europeia através das nossas escolhas de consumo.. Neste site, encontra uma série de marcas a evitar e excelent...
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Claudia Guimas Almeida @cgalmeida.bsky.social · 06/03/2025
Sad times for science “For all this talk about free speech, this is direct censorship of scientific research.” www.nature.com/articles/d41...
nature.com
Exclusive: NIH to terminate hundreds of active research grants
Studies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature.
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MwahahahahahadScientist @mads100tist.bsky.social · 01/03/2025
If you're in the US, considering Europe for your PhD, and you identify as a minority, I will chat with you and review any application documents you need 🧪
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Público @publico.pt · 02/03/2025
Há quase um ano que os cientistas aguardam pelos resultados das candidaturas ao principal concurso para financiamento de projectos de investigação. Alguns, no entanto, já tiveram resposta.
publico.pt
Ainda não há resultados dos projectos da FCT, mas alguns cientistas já receberam o “sim”
Há quase um ano que os cientistas aguardam pelos resultados das candidaturas ao principal concurso para financiamento de projectos de investigação. Alguns, no entanto, já tiveram resposta.
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Claudia Guimas Almeida @cgalmeida.bsky.social · 02/03/2025
Obrigada @publico.pt por esta notícia desde Dezembro que os cientistas vivem num estado de ansiedade por causa da FCT, e desde que sairam para alguns a injustiça é imensurável porquê ? www.publico.pt/2025/03/02/c...
publico.pt
Ainda não há resultados dos projectos da FCT, mas alguns cientistas já receberam o “sim”
Há quase um ano que os cientistas aguardam pelos resultados das candidaturas ao principal concurso para financiamento de projectos de investigação. Alguns, no entanto, já tiveram resposta.
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Ines Carvalho @inesccarv.bsky.social · 13/02/2025
O normal na ciência em Portugal! www.publico.pt/2025/02/13/c...
publico.pt
Apoio de 20 milhões de euros para contratar cientistas ainda não foi renovado: “Voltamos ao zero”
Verba de 20 milhões de euros para apoiar um terço das despesas com a contratação de cientistas foi aprovada em 2024. Instituições de ensino superior mostram-se preocupadas com falta de garantias.
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Claudia Guimas Almeida @cgalmeida.bsky.social · 07/02/2025
Concordando com o acesso a todas as publicações científicas não vejo realmente implementar. O guia diz que posso publicar num jornal open access que tem um custo exorbitante apesar de a política de acesso aberto não permitir o pagamento duplo, pela ciência e pela publicação acessoaberto.fct.pt
acessoaberto.fct.pt
Política de Acesso AbertoInfoFundação para a Ciência e a TecnologiaFundação para a Ciência e a TecnologiaLinkedInLinkedInLínguaInfoFundação para a Ciência e a TecnologiaLinkedInYouTubeTwitter
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Esther Choo @choo.bsky.social · 22/01/2025
My NIH study section that was to meet tomorrow was one of those canceled. This represents many months of work by the applicants and by the NIH staff and reviewers. Devastating is the correct word.
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Belinda Barnet @manjusrii.bsky.social · 21/01/2025
Donate to Wikipedia. Do it today, and every time one of the broligarchs has a tantrum because he can’t buy it
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Thiago Carvalho @cyrilpedia.bsky.social · 07/01/2025
'The FDA’s Center for Drug Evaluation and Research approved 50 new small molecules, biologics and oligonucleotide therapeutics last year. The class of 2024 was a little smaller than that of 2023, which had 55 approvals and was the second largest in the past 30 years' www.nature.com/articles/d41...
nature.com
2024 FDA approvals
The FDA approved 50 new therapeutics in 2024, with green lights for a novel schizophrenia drug, a first NASH medicine and much more.
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Thiago Carvalho @cyrilpedia.bsky.social · 22/12/2024
"If there is something you can technically do but that won’t answer your question, then don’t do it." @victora.bsky.social www.cell.com/news-do/50-i...
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Claudia Guimas Almeida @cgalmeida.bsky.social · 19/12/2024
Where is the muscle? Arrows 🙏 please
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Claudia Guimas Almeida @cgalmeida.bsky.social · 16/12/2024
Já começo a duvidar 🤔
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Claudia Guimas Almeida @cgalmeida.bsky.social · 16/12/2024
Alguém sabe quando saem os resultados dos projetos FCT (PTDC)? @mcti.bsky.social #FCT
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Claudia Guimas Almeida @cgalmeida.bsky.social · 06/12/2024
Yes please
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Sally Lowell @cellysally.bsky.social · 03/12/2024
Highly-respected non-profit journals like @dev-journal.bsky.social support scientific communities But after rejection at glam journals, it is tempting to avoid re-review by sliding through commercial ecosystems BUT WAIT! LOOK! “We will consider papers with reviewer reports from other journals” 😍
journals.biologists.com
Constructive Critics: Development's approach to peer review
We're all familiar with complaints about peer review. Some think it's biased – editors (especially from ‘those’ journals) seem to have too much power to decide what gets published. It can be opaque – ...
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Claudia Guimas Almeida @cgalmeida.bsky.social · 30/11/2024
Dis you see our last paper in J neurosci? No endosomes only cytoskeleton! It was fun!
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Christian Gonzalez-Billault @glezbillault.bsky.social · 30/11/2024
Cytoskeleton rules!!!
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Junyue Cao @junyuecao.bsky.social · 29/11/2024
Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!
tinyurl.com
A panoramic view of cell population dynamics in mammalian aging
To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...
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Claudia Guimas Almeida @cgalmeida.bsky.social · 28/11/2024
Send me a message for full-text 🙏
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Claudia Guimas Almeida @cgalmeida.bsky.social · 28/11/2024
Yes! Our discovery that CD2AP loss of function might increase the risk of Alzheimer’s by disrupting dendritic spines directly via F-actin regulation and indirectly via beta-amyloid production is on the cover #jneurosci www.jneurosci.org/content/44/4...
jneurosci.org
The Alzheimer's Disease Risk Gene CD2AP Functions in Dendritic Spines by Remodeling F-Actin
CD2-associated protein (CD2AP) was identified as a genetic risk factor for late-onset Alzheimer's disease (LOAD). However, it is unclear how CD2AP contributes to LOAD synaptic dysfunction underlying A...
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Claudia Guimas Almeida @cgalmeida.bsky.social · 28/11/2024
www.publico.pt/2024/11/27/c... Apesar do alerta de muitos investigadores com posições de liderança na ciência que se faz neste país o partido socialista absteve-se ao reforço do orçamento que visava não aumentar mas apenas não diminuir face ao ano passado. @ciencia_pt 🧪
publico.pt
Proposta para aumento do orçamento da FCT chumbada no Parlamento
O partido Livre tinha apresentado uma proposta para transferir 70 milhões de euros para o orçamento da FCT – colmatando o corte de 68 milhões de euros no Orçamento do Estado.
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Claudia Guimas Almeida @cgalmeida.bsky.social · 26/11/2024
Mechanisms of neuronal aging
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BioImaging North America @bioimagingna.bsky.social · 25/11/2024
Happy #MicroscopyMonday! The recordings of the #Virtual #I2K2024 workshops are available now tinyurl.com/VirtualI2K20... Thanks to all who presented! Please re-share! 2022 and 2023 content available too: www.youtube.com/@I2KConference
Virtual I2K Flyer notifying that the Recordings are available on the I2K YouTube channel: https://www.youtube.com/@I2KConference
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Claudia Guimas Almeida @cgalmeida.bsky.social · 25/11/2024
That you need to fly less 🫢
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Markus Eichhorn @markuseichhorn.bsky.social · 22/11/2024
Who should you nominate as reviewers for your manuscript? After a long chat with a post-grad it appears that there's a lot of misguided advice out there. Thread 👇
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Anna Clemens, PhD @annaclemens.com · 19/11/2024
As an academic, when you're so busy with your service, teaching, and administrative commitments, you often don't make time to write. 😮‍💨 That's why writing retreats can be SO valuable: buff.ly/48vtfmg #PhDchat #NewPI #ECRchat
buff.ly
Academic Writing Retreats
Academic writing retreats are either hosted off-campus or virtually and can last from a day up to a whole week. Find out how attending writing retreats can boost your productivity (and joy!) writing…
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The Company of Biologists @biologists.bsky.social · 19/11/2024
Are you an #ECR who would like to attend a #microscopy or #bioimageanalysis training course in the next ~6 months but don't have sufficient funding, check to see if you are eligible for our JCS-FocalPlane Training Grant. Next deadline: 22 November 2024 www.biologists.com/grants/jcs-f...
Microscopy Training Grants
Supporting microscopy training for early-career researchers in cell biology 

Apply for a grant of up to £1000

Journal of Cell Science FocalPlane
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Namnezia 🥑 @namnezia.bsky.social · 30/10/2024
Apply to the Neurobiology course, that’s where the cool kids hang out. It’s one of the few opportunities you’ll get to truly explore the “fucking around” phase of science, where you try out creative projects and wild ideas, while surrounded with a ton of excellent faculty and students and resources.
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Claudia Guimas Almeida @cgalmeida.bsky.social · 17/11/2024
Highly recommended
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Claudia Guimas Almeida @cgalmeida.bsky.social · 15/11/2024
A Joana explica bem o que não se quer, investir no futuro na ciência não é prioridade para o governo de Portugal
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Claudia Guimas Almeida @cgalmeida.bsky.social · 15/11/2024
Welcome to NOVA!
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Claudia Guimas Almeida @cgalmeida.bsky.social · 15/11/2024
Exactly let’s see what happens
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Claudia Guimas Almeida @cgalmeida.bsky.social · 14/11/2024
You can find us in Lisbon www.nms.unl.pt/research/res...
nms.unl.pt
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Claudia Guimas Almeida @cgalmeida.bsky.social · 14/11/2024
Wiley sent me a nice email “Dear Cláudia Almeida, Your work, Deacidification of endolysosomes by neuronal aging drives synapse loss, has received over 1,000 views*. Now that’s something to celebrate!” #aging #brain #cellbio #neuroscience onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Deacidification of endolysosomes by neuronal aging drives synapse loss
Enlarged late-endocytic organelles accumulate close to synapses in aged neurons and the aged brain.Functionally, aged endolysosomes are less acidic and degradative despite accumulating cathepsin D. I...
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Claudia Guimas Almeida @cgalmeida.bsky.social · 14/11/2024
Just landed on bluesky, x has been fun as it was. I hope science can find momentum under this bluesky 😀
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